Lisinopril's pharmacokinetics are linear and dose-proportional throughout the therapeutic range. Following oral administration, lisinopril is quickly absorbed from the digestive system, reaching peak plasma concentrations in about an hour. Lisinopril has a 25% bioavailability, and food has no impact on absorption.
A carboxylic acid derivative and an acylglucuronide conjugate of the parent compound are the two main metabolites of lisinopril that are produced by the liver following extensive metabolism of the drug. Both metabolites have pharmacological activity, but the carboxylic acid derivative has a half-life that is about 12 hours instead of 2 hours longer than lisinopril. Patients with normal renal function experience a total clearance of lisinopril of approximately 34 mL/min.
If you take any other medications, herbs, or vitamins, lisinopril may interact with them. Before beginning to take lisinopril, be sure to inform your doctor of all the drugs, herbs, and vitamins you are currently taking.
The following medicines may interact with lisinopril:
Benazepril, captopril, enalapril, fosinopril, moexipril, perindopril, quinapril, and ramipril are ACE inhibitors. Benazepril is sold under the brand names Lotensin, Capoten, and Capoten.
Candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan) are angiotensin receptor blockers.
Dizziness, headaches, coughing, and fatigue are lisinopril's most frequent side effects. Skin rashes, allergic reactions, and kidney issues are a few additional potential side effects. Immediately get in touch with your doctor or seek medical help if you experience any severe side effects.
When you get up from a sitting or lying position, lisinopril may cause a slight drop in blood pressure. Postural hypotension is what this is also referred to as, and it is most likely to happen if you have been taking lisinopril for a long time. To prevent fainting or dizziness if you experience this side effect, get up slowly from a sitting or lying position.
Dosage and Administration
Lisinopril should be taken at a starting dose of 10 mg once daily. 20–40 mg given once daily is the typical maintenance dose. You can administer lisinopril either by itself or in conjunction with other drugs.
The same time every day should be used to take lisinopril. Taking it with or without food is acceptable. Take the missed dose as soon as you remember, then carry on with your regular dosing schedule. Never combine two doses into one.
Take Zestril as soon as you remember if you miss a dose. Skip the missed dose and resume your regular dosing schedule if your next dose is almost due. Never combine two doses into one.
Lisinopril overdose symptoms include low blood pressure (hypotension), lightheadedness, and fainting. Contact your neighborhood emergency room or poison control center right away if you believe you have taken too much of this medication.
Zestril should be kept at room temperature away from heat and moisture.