Premarin is a hormone replacement therapy (HRT) medication that supplies an individual with the female oestrogen hormone. This medication is usually a short-term treatment prescribed to lessen the symptoms of menopause.
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What is Premarin?

Premarin is an HRT prescription medication that is used for the treatment of symptoms and conditions associated with menopause. It can also be used to prevent osteoporosis in postmenopausal women who may be at risk of developing fragile bones. 

How does it work?

Premarin contains a mixture of conjugated oestrogen hormones which works to relieve the symptoms of menopause that are associated with the natural decline of oestrogen levels. 

Is Premarin suitable for me?

Some medicines may interfere with the effect of Premarin, so you should consult with your doctor before beginning this medication. 

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Side Effects

All medications can cause potential side effects, below we have listed some potential side effects, however, these do not always occur.

  • Abdominal uterine bleeding such as breakthrough bleeding or spotting, changes in menstrual flow, pelvic pain, vaginal inflammation and vaginal discharge
  • A tendency to get thrush
  • Breast pain, breast tenderness, swollen breasts, discharge from the nipples and changes in breast tissue
  • Feeling or being sick, a feeling of being bloated, abdominal pain

  • Headache or migraine

  • Dizziness

  • Changes in mood including anxiety, depression and irritability

  • Joint pain, leg cramps

  • Changes in your interest in sex (increased or decreased libido)

  • Visible swelling of the face or ankles

  • Rash, itchiness, acne and dark or red patches on the skin

  • Changes in hair growth (loss or increase)

  • Minor changes to the eye, difficulty wearing contact lenses

  • Changes in weight (increase or decrease)

  • Changes in your triglyceride levels (fatty substances in the blood)

  • An intolerance to glucose

  • Memory loss (dementia)

  • A worsening of chorea (an existing neurological disorder characterised by involuntary spasmodic movements of the body)

  • A worsening of asthma

  • A worsening of hypocalcaemia (low blood levels of calcium)

  • Gallbladder disease or jaundice (e.g. gallstones or yellowing of the skin)

  • Growth of benign meningioma (a tumour of the membranes around the brain or spinal cord)

  • Inflammation of the colon (part of the intestine) which may present as lower left sided abdominal pain and/or bloody diarrhoea

  • Induce or exacerbate symptoms of angioedema, which consists of generalized swelling of parts of the body, most frequently around the face, mouth, tongue and neck areas, particularly in women with hereditary angioedema.

Disclaimer: This website does not constitute as medical advice, you should also consult with a doctor before taking medication. If you experience any major reactions to any medication you are taking, you must seek immediate medical attention.


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All orders placed before 14:00 on weekdays will be delivered the next working day. For the majority of the UK, medication will be dispatched by Royal Mail, Monday to Friday, if ordered before 14:00. Dispatches are sent using Royal Mail's Next-Day Tracked 24-Hour service. We will email you tracking information directly and you should receive your order the day after dispatch.

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We know that many of our customers turn to us when they need personal medication, preferring to use our online service rather than shopping for the product face to face. That is why our delivery is always discreetly packaged in plain brown boxes or enveloped. You will not have to worry about any content descriptions, and the package will be for your eyes only!


Commonly Used Dosage Guidelines for Premarin.

For the treatment of menopausal symptoms:

  • The usual dose is one tablet every day. Your doctor will prescribe the lowest dose that will control your symptoms. Premarin 0.3 mg is the lowest starting dose. If your symptoms are not adequately controlled higher doses of Premarin can be used.

For the treatment of osteoporosis:

  • The usual dose is one 0.625 mg tablet every day but your doctor may advise you to use 1.25 mg each day. You and your doctor should review the need for treatment regularly.

Disclaimer: This website does not provide medical advice. No information listed on this website is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment before undergoing a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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What are the ingredients in Premarin?

Premarin contains the ingredients oestrogen, lactose monohydrate, microcrystalline cellulose, magnesium stearate, hypromellose, sucrose, hydroxypropyl cellulose, macrogol, carnauba wax, edible ink and coating.

What do I do if I forget to take Premarin?

If you forget to take a tablet don’t worry. Take it as soon as you remember and then carry on taking the remaining tablets at the usual time.

Do not take a double dose to make up for a forgotten tablet.

Missed tablets may cause a short period of light bleeding in women who have not had a hysterectomy.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

Is Premarin an oestrogen-only medication?

Premarin is an HRT that contains conjugated oestrogen which is a medical formula made up of several types of oestrogens. 

The other ingredients are lactose monohydrate, microcrystalline cellulose, magnesium stearate, hypromellose, sucrose, hydroxypropyl cellulose, macrogol, carnauba wax, edible ink and coating.

What should I avoid while on Premarin?

You should avoid drinking grapefruit juice while taking Premarin as it may affect the way that the medicine works.

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