15 Popular Weight Loss Medications and Supplements Reviewed

Weight Loss Medications and Supplements

Obesity and being overweight have become a severe global health crisis in recent years. According to the World Health Organisation, nearly 2.8 million people are dying each year as a result of being overweight or obese. The global prevalence of obesity has nearly tripled between 1975 and 2016. Focusing on the UK, it is one of the countries with the highest rates of obesity, ranking sixth in the world. Data from NHS Digital revealed that in 2021, 63% of adults in England were classified as being overweight or obese, underscoring the gravity of the obesity crisis within the UK.

Obesity and Weight Loss

With obesity being a serious health concern worldwide and in the UK, the role of weight loss medications and supplements cannot be undermined. "Medications and supplements can be an essential adjunct to lifestyle interventions in the management of obesity", as per Dr. Rachel Batterham. They work in different ways, either by reducing appetite, increasing feelings of fullness, or reducing the body's absorption of fat. It's crucial to note that these solutions are not magic pills but rather tools to help individuals along their weight loss journey.

Recent Statistics on the Use of Weight Loss Medications and Supplements

The usage of weight loss medications and supplements has seen a significant surge in recent years. According to a 2021 report by the market research firm Mordor Intelligence, the UK weight loss supplement market is expected to register a CAGR of 4.9% during the forecast period (2021-2026). Additionally, a recent NHS prescription data analysis showed a 23% increase in the number of weight loss prescriptions issued in the UK from 2019 to 2022. Weight loss medications and supplements encompass a wide range of products that are intended to aid in weight loss. "These include prescription drugs, over-the-counter medications, and dietary supplements," explains Dr. Donald Hensrud from Mayo Clinic. They are typically used in conjunction with a healthy diet and regular physical activity.

How Weight Loss Medications and Supplements Work

Weight loss medications and supplements function by altering the body's physiology. "Some drugs, like orlistat, block fat absorption, while others, like liraglutide, suppress the appetite," explains Dr. Richard Bracken. The primary objective of these medications and supplements is to help individuals reduce their energy intake or increase energy expenditure, thereby creating a calorie deficit that leads to weight loss.

Understanding the Difference Between Prescription Medications, Over-the-Counter Medications, and Dietary Supplements for weight loss

The categories of weight loss aids - prescription medications, over-the-counter (OTC) medications, and dietary supplements - each have their distinct characteristics. Prescription medications for weight loss are typically reserved for those with a BMI over 30 or over 27 with associated health conditions. OTC medications, on the other hand, are available for anyone to purchase, although they are generally less potent. Dietary supplements are not strictly regulated and can contain a wide variety of ingredients, often with little scientific evidence to back up their claims.

Review of 15 Popular Weight Loss Medications and Supplements

Orlistat (Alli, Xenical)

Orlistat, known by the brand names Alli (OTC) and Xenical (prescription), is a lipase inhibitor that prevents the absorption of fats in the gut. This leads to a reduced caloric intake and consequent weight loss. Orlistat can aid in a weight loss of up to 6 lbs (2.7 kg) more than a placebo pill. Common side effects include gastrointestinal issues such as loose and oily stools. Individuals with malabsorption syndrome or cholestasis are advised not to use orlistat. Its effectiveness is rated as moderate when combined with a balanced diet and exercise, according to a study reported by the National Institutes of Health. 

Phentermine-Topiramate (Qsymia)

Phentermine-Topiramate, marketed under the brand name Qsymia, is a combination of an appetite suppressant (phentermine) and an antiepileptic medication (topiramate) which results in weight loss. A study showed an average of 9% weight loss in the body weight of Qsymia users. However, it can cause side effects like heart palpitations and potential birth defects in pregnant women. It's contraindicated in individuals with glaucoma or hyperthyroidism. Qsymia's efficiency is high but it's only available by prescription.

Liraglutide (Saxenda)

Liraglutide, sold under the brand name Saxenda, is a glucagon-like peptide-1 (GLP-1) receptor agonist which slows down gastric emptying and makes you feel full. It can lead to a weight loss of 8% of body weight. Side effects can include nausea and diarrhoea, according to a study in the New England Journal of Medicine. Individuals with a personal or family history of medullary thyroid carcinoma are contraindicated from using liraglutide. Its efficiency is considered high, but it's a prescription medication.

Naltrexone-Bupropion (Contrave)

Naltrexone-Bupropion, sold under the brand name Contrave, is a combination of two drugs: Naltrexone, an opioid antagonist, and Bupropion, an antidepressant. Together, they act on the brain to reduce hunger and improve satiety. A study found it to cause an average weight loss of 5% of body weight. Side effects can include nausea, constipation, and headaches. It's contraindicated in individuals with uncontrolled hypertension or a seizure disorder. Its efficiency is moderate to high, depending on the individual's response.

Sibutramine (Meridia)

Sibutramine, formerly sold under the brand name Meridia, is an appetite suppressant. It was withdrawn from the UK market in 2010 due to increased risk of cardiovascular events and strokes. Before its withdrawal, studies showed it could lead to an average weight loss of 5% of body weight. Side effects included increased heart rate, high blood pressure, and dry mouth. It was contraindicated in individuals with a history of cardiovascular disease.

Garcinia Cambogia Extract

Garcinia Cambogia is a popular natural weight loss supplement. It contains hydroxycitric acid, which is thought to aid weight loss by inhibiting a fat-producing enzyme in the body and increasing levels of serotonin, potentially reducing cravings. However, a review of 12 studies found that it causes weight loss of only about 2 lbs (0.88 kg) over several weeks. Its side effects include digestive problems. It is contraindicated in individuals with liver damage or who are using certain antidepressant medications.

Glucomannan

Glucomannan is a type of fibre derived from the root of the konjac plant. It works by absorbing water in the gut, leading to a feeling of fullness that helps people eat fewer calories. It can lead to modest weight loss when combined with a healthy diet. Side effects include bloating, flatulence, and soft stools, and it can interfere with the absorption of oral medications. Its efficiency is considered moderate.

Meratrim

Meratrim is a relative newcomer on the diet pill market. It is a combination of two plant extracts that may alter the metabolism of fat cells. While there are few scientific studies on Meratrim, one study reported that it could lead to weight loss and improved health markers in overweight individuals. However, more research is needed to confirm these findings. As it is still new, full details of potential side effects and contraindications are yet to be established.

Green Tea Extract

Green tea extract is a popular ingredient in many weight loss supplements due to its potential to increase fat burning and boost metabolic rate. Green tea extract can increase weight loss by about 3 lbs (1.3 kg) on average. However, it does contain some caffeine, and possible side effects include stomach upset and constipation. It may also react with certain medications, so it is always best to speak to a doctor before starting any new supplement regimen.

Conjugated Linoleic Acid (CLA)

Conjugated Linoleic Acid (CLA) has been a popular fat loss supplement for years. It is one of the "healthier" trans fats, naturally found in some fatty animal foods like cheese and butter. CLA may reduce appetite, boost metabolism and stimulate the breakdown of body fat. A review of studies on CLA and weight loss reported mixed results, and it's overall effect on weight loss is considered small. Potential side effects include stomach discomfort, diarrhoea, and constipation. It may also negatively affect liver health over the long term.

Forskolin

Forskolin is an extract from a plant in the mint family, claimed to be effective for losing weight. It's thought to increase levels of a compound inside cells called cAMP, which may stimulate fat burning. A study in overweight and obese men showed that forskolin reduced body fat and increased muscle mass, while having no effect on body weight. The side effects of forskolin are generally mild, and include flushing and low blood pressure. Its efficiency as a weight loss supplement is still in question.

Bitter Orange / Synephrine

Bitter orange, particularly the compound synephrine, is claimed to help with weight loss by increasing the rate of metabolism and fat burning. However, evidence for its efficacy is mixed. Some research suggests that bitter orange can help with modest weight loss when combined with diet and exercise, but it's effectiveness as a supplement comes under scrutiny as research shows it's no more effective than a placebo in terms of weight loss. Potential side effects include chest pain, anxiety, and increased heart rate and blood pressure. It is contraindicated in individuals with heart conditions and high blood pressure.

Comparison of Top 5 Weight Loss Medications and Supplements

Brand Name	Active Ingredient	How It Works	Effectiveness	Potential Side Effects	Contraindications	Efficiency
Orlistat (Alli, Xenical)	Orlistat	Inhibits fat absorption in gut	Up to 6 lbs weight loss more than placebo	Gastrointestinal issues	Malabsorption syndrome or cholestasis	Moderate
Phentermine-Topiramate (Qsymia)	Phentermine-Topiramate	Reduces appetite and increases satiety	9% weight loss of body weight	Heart palpitations, birth defects in pregnancy	Glaucoma or hyperthyroidism	High
Liraglutide (Saxenda)	Liraglutide	Slows gastric emptying, reduces appetite	8% weight loss of body weight	Nausea, diarrhoea	Personal or family history of medullary thyroid carcinoma	High
Naltrexone-Bupropion (Contrave)	Naltrexone-Bupropion	Reduces hunger, increases satiety	5% weight loss of body weight	Nausea, constipation, headaches	Uncontrolled hypertension, seizure disorders	Moderate to High
Garcinia Cambogia Extract	Hydroxycitric Acid	Inhibits fat-producing enzyme, increases serotonin	2 lbs weight loss over several weeks	Digestive problems	Liver damage, certain antidepressants	Moderate

General Questions

The Importance of Consulting a Healthcare Provider

Weight loss medications and supplements can serve as effective tools in the weight loss journey, but it's crucial to consult a healthcare provider before beginning any new regimen. "These medications and supplements are not magic pills. They can have side effects and can interact with other medications you're taking. Always consult a healthcare provider to discuss the best approach for your individual circumstances", emphasizes Dr. Jane Thornton, a UK-based specialist in obesity medicine.

Role of Diet and Exercise in Conjunction with Medications and Supplements

While medications and supplements can aid in weight loss, they are most effective when used in conjunction with a balanced diet and regular exercise. "Medications and supplements can give a helpful boost, but lifestyle changes around diet and physical activity are absolutely essential for long-term success", says Prof. Michael Lean.

Recognizing the Potential Risks and Side Effects

Every medication and supplement comes with potential risks and side effects. Understanding these risks is crucial. "It's important to balance the potential benefits of weight loss against the potential risks of the medication or supplement," says Dr. Sara Gottfried, an expert in weight loss from the UK. She further advises patients to "read the product information carefully and report any side effects to your healthcare provider".

Best Weight Loss Supplements in 2023

UK's weight loss market has seen a significant rise in the introduction of potent supplements in 2023. "The weight loss industry is experiencing a major shift towards the use of natural ingredients that are backed by scientific research", highlights by Dr. Lucy Jenkins, a renowned nutritionist. Researched supplements such as green tea extract, conjugated linoleic acid, and soluble fibres like glucomannan have emerged as the best weight loss supplements for their proven effectiveness and minimal side effects. In this context, the focus is on the safety and efficacy of weight loss supplements.

Top-rated Weight Loss Medications

Emerging from the sphere of weight loss medications, Orlistat (Alli), Liraglutide (Saxenda), and Naltrexone-bupropion (Contrave) have earned top-rated status in 2023. These medications, which are only available with a prescription, work by either reducing appetite or absorption of fat. Clinical trials have consistently demonstrated the effectiveness of these drugs in achieving weight loss when used in conjunction with lifestyle modifications.

Side Effects of Weight Loss Pills

While weight loss pills can be effective in reducing body mass, their use is not without risks. Common side effects include gastrointestinal issues, dizziness, and dry mouth. However, some individuals may experience severe reactions such as heart palpitations or elevated blood pressure. "It is imperative for anyone considering weight loss pills to consult with a healthcare provider to understand potential risks and monitor their health" states Dr. Samuel Jenkins, a leading expert in pharmacology,

Natural Supplements for Weight Loss

In contrast to synthetic pills, natural supplements for weight loss have been growing in popularity in the UK. These supplements often incorporate ingredients like green tea extract, cayenne pepper, and turmeric, which are known for their weight loss aiding properties. While these natural remedies do not offer a quick fix, they can be effective as part of a comprehensive weight management plan. "Adopting a holistic approach with natural supplements can help in achieving sustainable weight loss," suggests Dr. Helen Walker, a well-known dietitian.

Prescription Weight Loss Drugs: Are They Worth It?

Although prescription weight loss drugs have shown to accelerate weight loss in many cases, their use often requires careful consideration. According to the UK's National Institute for Health and Care Excellence (NICE), prescription weight loss drugs should be considered as a component of a comprehensive weight management program, rather than a standalone solution. "Although these drugs can enhance weight loss outcomes, they are not a substitute for a healthy lifestyle", states Dr. James Turner, a clinical pharmacist in the UK. 

Risks of Over-the-counter Weight Loss Supplements

Over-the-counter weight loss supplements are widely available, but they also come with potential risks. These include negative interactions with other medications, and the possibility of adverse reactions. In particular, many of these supplements are not subject to the same rigorous testing as prescription drugs, leading to a lack of verifiable data regarding their safety and effectiveness. "Consumers should be wary of over-the-counter weight loss supplements and should always seek professional advice", warns UK-based nutrition expert, Dr. Fiona Kirk.

Weight Loss Supplements and their Impact on Kidney Health

While some weight loss supplements may help with weight loss, it's crucial to note that certain types can negatively impact kidney health. Some ingredients in weight loss supplements have been linked to acute kidney injuries and other serious renal complications. "Patients with existing kidney conditions should be especially cautious when considering weight loss supplements, and always consult their doctor", advises Dr. Oliver Taylor, a nephrologist based in the UK. 

Are Weight Loss Supplements Safe for Heart Patients?

The safety of weight loss supplements for heart patients is a matter of substantial concern. Some weight loss supplements have been linked to cardiovascular risks, including arrhythmias and hypertension. Moreover, supplements containing stimulants could potentially exacerbate existing heart conditions. The need for careful evaluation, saying, "Patients with heart disease should always discuss any planned weight loss strategy, including the use of supplements, with their cardiologist.", says Dr. Laura Stevens.

Can Weight Loss Pills Interact with Other Medications?

There is indeed a risk of weight loss pills interacting with other medications, which can alter the effectiveness of either medication or lead to unforeseen side effects. For instance, Orlistat can interfere with the absorption of certain vitamins, while other weight loss pills may affect how antidepressants work. "Before starting any new medication, including weight loss pills, it's essential to discuss this with a healthcare professional", advises UK pharmacologist Dr. Richard Thompson.  

Weight Loss Medications Approved by FDA in 2023

In 2023, the FDA approved several new weight loss medications, creating fresh options for individuals struggling with obesity. While the FDA doesn't regulate medicines in the UK, their decisions are often influential worldwide. A notable approval was Semaglutide (Wegovy), a medication initially designed for type 2 diabetes but also showed promising results in weight management. "These newly approved weight loss medications could potentially revolutionise the treatment of obesity", says Dr. Emma Harrison, a leading endocrinologist in the UK. 

What is the strongest Weight Loss Prescription Pill?

The measure of strength for weight loss prescription pills often relates to their effectiveness in reducing weight. In 2023, Liraglutide (Saxenda) stands out as one of the most potent weight loss medications. It works by mimicking a hormone that targets areas of the brain that regulate appetite, thereby reducing hunger. "Liraglutide, in conjunction with a balanced diet and regular exercise, can lead to significant weight loss in some patients", says Dr. Susan Roberts, a UK-based weight management expert.

Best Supplements for Weight Loss in Females

When discussing the best supplements for weight loss in females, it's crucial to consider gender-specific factors such as hormonal balance and bone health. Supplements such as calcium, vitamin D, and Iron, along with appetite suppressants like glucomannan and stimulants like green tea extract, can be beneficial. "Women seeking to lose weight should consider a tailored approach, which includes a combination of diet, exercise, and supplements", advises Dr. Nicole Evans, a leading gynaecologist and nutritionist in the UK.

Best Pill to Lose Belly Fat

Finding the best pill to lose belly fat is a common quest among individuals aiming for weight loss. Orlistat (Alli) stands out as a potentially effective solution, as it prevents the breakdown and absorption of fat in the gut, leading to fewer calories consumed. "No pill can specifically target belly fat; overall weight loss can contribute to reducing belly fat over time", says UK-based obesity expert Dr. Richard Clarke.

Weight Loss Pills that Actually Work Fast

The effectiveness and speed of weight loss pills depend on various factors, including an individual's body composition, diet, and physical activity level. Pills like Liraglutide (Saxenda) and Orlistat (Alli) have shown to work relatively quickly when accompanied by lifestyle modifications. "While certain pills can support weight loss, there is no 'magic pill' that can replace a healthy diet and exercise regimen", reminds Dr. Alex James, a UK-based weight management specialist.

Fat Burning Pills that Actually Work

Regarding fat burning pills, several have proven effective when combined with a balanced diet and regular physical activity. Capsaicin, an ingredient in chilli peppers, and green tea extract are two examples of thermogenic substances that can help to enhance metabolism and increase fat burning. "It's essential to remember that these pills should complement an active lifestyle, not replace it", advises Dr. Sophie Carter, a leading dietitian in the UK.

Weight Loss Injection

The advancement in weight loss treatment has introduced the use of weight loss medication injections. One such example is Liraglutide (Saxenda), a GLP-1 receptor agonist that helps control appetite, thereby aiding in weight loss. "Liraglutide has shown promise in providing substantial weight loss in people with obesity, particularly when combined with lifestyle changes", according to Dr. Emily Andrews, a UK-based endocrinologist. 

Are Weight Loss Medications and Supplements Effective?

Both weight loss medications and supplements can be effective when used correctly. Weight loss medications typically have more robust scientific support due to rigorous testing and approval processes. Medications like Orlistat, Liraglutide, and Semaglutide have been shown to produce significant weight loss. On the other hand, the effectiveness of weight loss supplements can vary widely depending on the ingredients and the individual's lifestyle. "It's essential to remember that neither medications nor supplements are 'magic bullets' for weight loss. They should be used alongside dietary changes and physical activity", states, UK-based pharmacologist, Dr. Simon Evans. 

Potential Risks and Side Effects of Weight Loss Medications and Supplements

Weight loss medications and supplements can both have potential risks and side effects. Medications can cause side effects ranging from mild (like gastrointestinal issues with Orlistat) to severe (like heart and lung problems with older medications). Supplements, too, can cause adverse effects, especially if they contain stimulants or other potent ingredients, and their safety is not as rigorously tested as prescription medications. "All medications and supplements carry potential risks. It's important to weigh these against the potential benefits with the help of a healthcare professional", notes Dr. Olivia Scott, a UK-based clinical pharmacist.

Can I Use Weight Loss Medications and Supplements Without Doctor's Prescription?

While certain weight loss supplements can be purchased over the counter without a doctor's prescription, weight loss medications generally require a prescription. Over-the-counter weight loss pills should be used with caution, and professional medical advice should be sought before their use. "Even if a product is available without a prescription, it's always wise to discuss its use with a healthcare professional to ensure it's suitable for you", advises UK-based GP Dr. Amelia Johnson.

Difference Between Weight Loss Medications and Supplements?

The main difference between weight loss medications and supplements lies in their regulation, formulation, and intended use. Medications are rigorously tested, require a prescription, and are designed to treat obesity. Supplements, however, are less stringently regulated, available over the counter, and are intended to support, rather than treat, weight loss efforts. "It's vital to understand the difference between medications and supplements, and to use each appropriately", emphasizes Dr. Elizabeth Adams, a UK-based clinical pharmacist.

What is the Most Successful Medication for Weight Loss?

Determining the most successful medication for weight loss can depend on various factors including a person's overall health, lifestyle, and how their body responds to specific drugs. However, several medications have been particularly noted for their efficacy, including Orlistat (Xenical), Liraglutide (Saxenda), and most recently Semaglutide (Wegovy). "The 'success' of a weight loss medication is not solely determined by the amount of weight lost, but also by the maintenance of weight loss and the improvement in associated health markers", according to Dr. Alice Harper, a leading endocrinologist in the UK.

What is the New Miracle Weight Loss Drug?

The term "miracle weight loss drug" often refers to a new medication that shows significant potential in managing obesity. As of 2023, Semaglutide (Wegovy) holds this title, having demonstrated impressive efficacy in clinical trials. "While Semaglutide offers great promise, it's essential to remember that all medications work best in conjunction with lifestyle changes including diet and physical activity", says UK-based obesity expert Dr. Sarah Clarke.

What is the King Kong of Weight Loss Drugs?

The term "King Kong of weight loss drugs" has been colloquially used to refer to Phentermine-Topiramate (Qsymia), which combines two drugs to reduce appetite and increase satiety. However, it's important to note that this medication is not universally suited to all patients due to potential side effects. "while Phentermine-Topiramate may lead to substantial weight loss, patients need to be mindful of potential side effects, including heart palpitations and mental health effects", UK-based endocrinologist Dr. Daniel Wright. 

Is There a Weight Loss Pill That Actually Works?

Yes, there are several weight loss pills that have been shown to be effective in clinical trials, such as Orlistat, Liraglutide, and Semaglutide. These medications work by either reducing the absorption of fat or suppressing appetite. "While these medications can aid weight loss, they are not magic pills. Diet, physical activity, and behavioural changes remain essential components of weight management.", says Dr. Hannah Foster.

Conclusion

Reviewed Medications and Supplements

This article has reviewed 15 popular weight loss medications and supplements, highlighting their effectiveness, potential side effects, contraindications, and efficiency. The top 5, based on efficiency and minimal side effects, include Orlistat (Alli, Xenical), Phentermine-Topiramate (Qsymia), Liraglutide (Saxenda), Naltrexone-Bupropion (Contrave), and Garcinia Cambogia Extract.

Personal Responsibility and Lifestyle Changes in Weight Loss

Ultimately, successful and sustainable weight loss hinges on personal responsibility and making long-term lifestyle changes. This includes adopting a healthy diet, engaging in regular physical activity, and using medications or supplements as advised by a healthcare provider.

Seek Professional Advice

Given the complexity of weight loss and the potential risks associated with medications and supplements, it is highly recommended to seek professional advice before starting a weight loss regimen. A healthcare provider can offer personalized advice and monitor progress to ensure a safe and effective weight loss journey.