Looking for an independent Youth & Earth NMN review before you buy? Youth & Earth is one of the most recognisable longevity brands in Britain, and its Nicotinamide Mononucleotide (NMN) is a genuine benchmark for purity. In this guide we assess the product on the things that actually matter — purity, dose, form, third-party testing, price and safety — and place it side by side with the Welzo NMN Pro 1000 (Ultra Purity) so you can decide which suits your goals. Everything here is grounded in published human research and each brand's own certificates of analysis, with no exaggerated health claims.
New to the category? Start with our pillar guide to longevity supplements and our foundational guide to NMN benefits, side effects and dosage. If you already know what you want, browse the full range of NMN supplements or our wider anti-ageing and longevity supplements, and read our NAD+ supplement guide for the mechanism behind the category.
Welzo NMN Pro 1000 (Ultra Purity) delivers 1000 mg of NMN per two-capsule serving. Image: Welzo.
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Nicotinamide mononucleotide (NMN) is a molecule derived from vitamin B3 and found in trace amounts in foods such as broccoli, avocado and edamame. Its appeal comes from one job in particular: NMN is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme that every cell in your body uses for energy production, DNA repair and hundreds of metabolic reactions.
The reason NMN has become one of the most-discussed longevity supplements is simple. NAD+ availability declines with age, and researchers have documented lower NAD+ abundance in older adults, which is associated with reduced muscle function (Janssens et al., 2022). The hypothesis being tested in clinical trials is whether topping up the NAD+ pathway with a precursor like NMN can support cellular energy and healthy ageing. We cover exactly what has — and has not — been proven in the evidence section below, and in depth in our review of whether popular longevity compounds actually work.
NMN is not the only NAD+ precursor. Nicotinamide riboside (NR, sold as Tru Niagen and similar) sits one step earlier in the pathway. If you are weighing the two, our dedicated comparison of Tru Niagen vs NMN breaks down the differences, and Urolithin A vs NMN compares NMN with a mitochondrial-focused alternative.
Youth & Earth is a UK longevity brand established in 2019. It was among the first companies to sell NMN in the United Kingdom and describes itself as one of the largest suppliers of NAD+ boosters in the UK and Europe. The brand has been featured in lifestyle titles including Vogue and Tatler, and it maintains strong independent review scores on Trustpilot and Feefo, where customers frequently highlight fast, personable customer service.
The company sells a broad longevity catalogue — sublingual and capsule NMN, spermidine, calcium AKG, liposomal vitamins and its own "V14" longevity blend. For this Youth & Earth NMN review we focus specifically on the NMN products, since that is what most readers are searching for. If you want a wider market view, see our roundups of the Vitality Pro NMN review, the Renue By Science review and the Viva NMN review.
Youth & Earth's NMN comes in two formats, and the distinction matters when you compare it with capsule-only competitors.
The flagship is a sublingual powder — a fine-ground NMN that you hold under the tongue for around 60 seconds before swallowing. Sublingual delivery is designed to let some NMN absorb through the tissue under the tongue rather than passing entirely through the digestive tract. The powder starts from around £29.99 for smaller sizes, with larger tubs (roughly £124.99) bringing the per-serving cost down for regular users. It is vegan, and free from gluten, GMO and soy. If the sublingual route appeals to you, our explainer on sublingual NMN covers the theory and the caveats.
Youth & Earth also offers enteric-coated capsules in 250 mg or 500 mg strengths, priced around £24.99 for 60 capsules. The enteric coating is intended to protect NMN from stomach acid and support absorption further down in the intestine.
On purity, Youth & Earth is a strong performer. The brand states its NMN is minimum 99% pharmaceutical grade, and publishes certificates of analysis showing testing across 12 data points including purity, potency, heavy metals, microbiological contaminants and endotoxins. It also reports impressive stability data: purity remaining above 98% after three months at 40 °C and 75% humidity. All products are manufactured in a GMP-certified facility.
Prefer a high, fixed daily dose in a capsule? The Welzo NMN Pro 1000 (Ultra Purity) provides a full 1000 mg of NMN per two-capsule serving at £26.99, with a downloadable certificate of analysis and no fillers beyond a vegan capsule shell.
Both are UK-based, third-party-tested NMN products from reputable retailers, so the honest differences come down to format, per-serving dose and price. Here is a like-for-like summary based on each brand's published specifications.
| Feature | Youth & Earth NMN | Welzo NMN Pro 1000 (Ultra Purity) |
|---|---|---|
| Format | Sublingual powder or enteric-coated capsules | Vegan capsules |
| Dose per serving | Powder: adjustable · Capsules: 250 mg or 500 mg each | 1000 mg (2 capsules) |
| Purity | Minimum 99% pharmaceutical grade | High-purity NMN, third-party verified |
| Third-party tested | Yes — 12 data points, COA published | Yes — COA downloadable on product page |
| Fillers | No additives/fillers (powder); enteric coating on capsules | HPMC capsule + vegetable magnesium stearate only |
| Indicative price | Powder from £29.99 · Capsules ≈ £24.99 (60) | £26.99 for 60 capsules (30 servings) |
| Manufacturing | GMP-certified facility | GMP standards, UK & EU quality control |
| Vegan | Yes | Yes |
| Best for | Sublingual fans; those who like adjustable dosing | A high, fixed 1000 mg daily dose in a simple capsule |
Prices and specifications are indicative and change over time — always confirm on the live product pages before purchasing. For broader value comparisons, see the cheapest NMN in the UK and our guide to where to buy NMN in the UK.
Because NMN is a relatively young supplement category, quality varies widely between sellers, and independent testing has repeatedly found products that fail to match their label claims. That is why purity and verification should sit at the top of your checklist — above brand hype.
A purity figure tells you how much of the powder is genuinely NMN versus by-products or contaminants. Both Youth & Earth (minimum 99% pharmaceutical grade) and Welzo (third-party-verified high-purity NMN) publish this. What you want to avoid is any product that claims purity without a certificate to back it up. Our guide on reading a supplement certificate of analysis shows you exactly what to look for, and our explainer on third-party tested supplements covers why independent labs matter.
Cheaper NMN is sometimes bulked out with fillers. Welzo's NMN Pro 1000 lists only the NMN, a vegan HPMC capsule and vegetable magnesium stearate (a common flow agent), while Youth & Earth's powder contains no added fillers at all. If clean labels matter to you, read our breakdown of common supplement fillers and which are worth avoiding.
This is the most important part of any honest NMN review, and where we apply the strictest standard: only published human trials, with no overstated claims.
The landmark human study was published in Science in 2021. In a 10-week randomised, placebo-controlled, double-blind trial of 25 postmenopausal women with prediabetes, 250 mg of NMN daily significantly increased muscle insulin sensitivity and insulin signalling compared with placebo (Yoshino et al., 2021; registered as NCT03151239). It is an important proof-of-concept — though it was small, specific to one population, and some researchers have debated aspects of the design.
Several trials show NMN reliably raises blood NAD+. A multicentre, randomised, double-blind study of 80 healthy middle-aged adults found that 300–900 mg daily produced dose-dependent increases in blood NAD+ over 60 days, alongside improvements in a six-minute walking test and a measure of blood biological age (Yi et al., 2022, GeroScience). A separate placebo-controlled trial of 66 adults aged 40–65 reported an 11.3% rise in serum NAD+/NADH by day 30 (Huang, 2022, Frontiers in Aging).
Being realistic matters. A 12-week trial of NMN in healthy older men raised NAD+ metabolites but did not significantly improve overall cognitive scores, and other endpoints such as walking endurance have shown mixed results across studies (see the Cognitive Vitality evidence review). No NMN product is a medicine, none can claim to reverse ageing, and the long-term outcome data in humans is still being gathered. NMN is sold as a food supplement to support cellular energy and NAD+ levels — not to treat, cure or prevent any disease. For a candid look at where the marketing outruns the science, see our articles on is NMN a scam? and longevity supplements that don't work.
Expert context: The Science authors concluded that NMN increased muscle insulin sensitivity and remodelling in this group — a documented, peer-reviewed finding rather than a marketing claim. As with any emerging compound, benefits build gradually with consistent use, and results vary by age, baseline NAD+ and lifestyle. Reviewed for accuracy by Dr Zeeshan Afzal of the Welzo medical team.
Human trials have used everyday doses from 250 mg up to 900 mg, and dedicated safety studies have tested higher. Many people start lower and build up. If you are unsure where to begin, our guides on NMN dosage by age and how to start longevity supplements walk through sensible ramp-up strategies.
NMN is commonly taken in the morning to align with your natural energy rhythm. Whether to take it with or without food, and the ideal timing, is covered in when to take NMN and taking NMN with food. Welzo's NMN Pro 1000 is designed to be taken as two capsules each morning with breakfast.
Some users pair NMN with TMG (trimethylglycine) to support methylation, or with resveratrol as a sirtuin activator. Whether you actually need it is discussed in do I need TMG with NMN?, and the popular combination is broken down in our NMN, TMG and resveratrol stack guide. You can also buy TMG in the UK here.
Across published human trials, NMN has generally been reported as safe and well tolerated. A randomised, double-blind, placebo-controlled study specifically evaluated 1250 mg of NMN daily for four weeks in 31 healthy adults and found it safe with no serious adverse effects (PMC9400576, 2022). Mild, transient effects some users report include nausea, digestive upset or headache, usually at higher doses.
NMN is not suitable for children, or for women who are pregnant or breastfeeding. If you take prescription medication or have an existing medical condition, speak to your GP or pharmacist before starting. Do not exceed the recommended daily intake, and if you experience any adverse reaction, stop and seek advice. Our articles on can you overdose on NMN? and what happens when you stop taking NMN address the most common safety questions.
This is a health topic (YMYL). The information here is educational and is not a substitute for personalised medical advice from a qualified professional. Verify a supplement's current regulatory status and suitability for you before purchase.
Youth & Earth NMN is a genuinely high-quality product and an easy recommendation for anyone who values verified purity and wants a sublingual option. Its minimum 99% pharmaceutical-grade rating, transparent 12-point testing and long track record make it one of the benchmark NMN products in the UK. The main considerations are the acquired taste of the powder and a premium price point, particularly for the larger tubs.
The Welzo NMN Pro 1000 (Ultra Purity) is the stronger pick if you want a high, fixed daily dose at a lower price. At £26.99 for 60 capsules it delivers a full 1000 mg per serving — double the strength of a single 500 mg Youth & Earth capsule — with a downloadable certificate of analysis, a clean vegan formula and same-day UK dispatch. For most people who simply want a simple, potent capsule taken once each morning, it offers excellent value.
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→ Shop the Welzo NMN Pro 1000 (Ultra Purity) — 1000 mg per serving, £26.99.
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→ Read the complete NMN benefits, side effects and dosage guide.
Yes. Youth & Earth NMN is a reputable, minimum 99% pharmaceutical-grade product, third-party tested across 12 data points and made in a GMP-certified facility. It is well regarded for purity and offers a sublingual powder option that many capsule-only brands do not. The main trade-offs are the powder's bitter taste and a premium price on larger sizes.
Both are UK-based, third-party-tested and vegan. The key difference is dose and format: Welzo NMN Pro 1000 provides a fixed 1000 mg per two-capsule serving at £26.99, while Youth & Earth offers 250–500 mg capsules (≈£24.99) or an adjustable sublingual powder from £29.99. Choose Youth & Earth for sublingual delivery; choose Welzo for a high fixed dose at lower cost.
Human trials commonly use 250–900 mg daily, with higher doses studied for safety. Many people start at a lower dose and build up. See our NMN dosage by age guide for tailored guidance, and consult a healthcare professional if you take medication.
Sublingual delivery is designed to let some NMN absorb through the tissue under the tongue, potentially bypassing part of digestion. Evidence directly comparing formats in humans is limited, so it comes down to preference and tolerance. Capsules offer convenient, consistent dosing. Read more in our sublingual NMN explainer.
Human trials show NMN reliably raises blood NAD+ levels, and a 2021 Science study found it improved muscle insulin sensitivity in prediabetic women. Other endpoints, such as cognition, have shown mixed results. NMN is a food supplement that may support cellular energy and NAD+ — it is not a medicine and cannot claim to treat disease. See is NMN a scam? for a balanced view.
Published trials generally report NMN as safe and well tolerated, including a study of 1250 mg daily for four weeks. Mild effects such as nausea or headache are occasionally reported at higher doses. It is not suitable for children or during pregnancy or breastfeeding, and you should consult a professional if you take medication or have a medical condition.
Most people take NMN in the morning to align with natural energy cycles; Welzo NMN Pro 1000 is taken as two capsules with breakfast. Timing and whether to take it with food are covered in when to take NMN.
Some users add TMG to support methylation, since NAD+ metabolism can use methyl groups. Whether it is necessary depends on your diet and overall stack — our guide on do I need TMG with NMN explains the reasoning.
NMN is available from specialist retailers such as Welzo and Youth & Earth. High-street chains stock it less consistently — see NMN at Boots and NMN at Holland & Barrett. For the best value, compare options in our cheapest NMN UK guide.
NAD+ levels can rise within weeks, but subjective benefits such as energy and focus typically build over 8–12 weeks of consistent daily use, and vary by individual. Our article on how long supplements take to work sets realistic expectations.
Medical disclaimer: This article is for general information and education only and is not a substitute for professional medical advice, diagnosis or treatment. Food supplements are not intended to diagnose, treat, cure or prevent any disease. Always read the label, do not exceed the recommended dose, and consult a qualified healthcare professional before starting any supplement — particularly if you are pregnant, breastfeeding, taking medication or have a medical condition. Prices and product specifications are correct at the time of writing and may change.
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