Pregnenolone

Pregnenolone is an endogenous steroid hormone also known as pregn-5-en-3β-ol-20-one or 3β-hydroxypregn-5-en-20-one (INN, USAN, BAN). Through the action of two cytochrome P450 enzymes, it is made from cholesterol. Pregnenolone serves as a natural neurosteroid and is also the starting material for the synthesis of all other endogenous steroids. The brain is one tissue where this naturally occurring progestogen and adrenal steroid is produced. Enhancing GABAergic neurotransmission and controlling glutamatergic N-methyl-D-aspartate (NMDA) receptors are its two main functions. This article is written to provide information to Welzo users so they can better understand Pregnenolone.
Overview
Uses
Side Effects
Medication
Ingredients
Supplements
Pharmacokinetics

What is Pregnenolone?

Russell Marker, an American chemist, first isolated pregnenolone in 1934 from the sarsaparilla plant Smilax aristolochiifolia. Marker separated pregnenolone from cholesterol using a novel technique he invented called acetolysis, which uses acetic anhydride.

Pregnenolone was first created in 1937 by British physician Gordon Thomas Searle and American endocrinologist Edward Charles Dodds from diosgenin, a sapogenin found in plants like yams and fenugreek.

Pregnenolone was discovered in the 1940s to be a crucial precursor in the biosynthesis of several other natural steroids, such as progesterone, cortisol, and testosterone.

In 1934, Schering AG in Germany introduced the first pregnenolone pharmaceutical preparation under the trade name Anapryl. The drug received American approval in 1938 to treat Addison's disease and in 1941 to treat acne. The use of pregnenolone in medicine has ended. It is still offered as a dietary supplement, where it is marketed as a "natural hormone" and various health benefits are asserted.

A steroid hormone called pregnenolone is created by the body from cholesterol. Progesterone, androstenedione, and testosterone are all precursors to this hormone. Age-related hormonal imbalances may be a result of decreased pregnenolone levels. Some people's memory and cognitive function have been shown to improve with pregnenolone supplementation. Additionally, it might enhance wellbeing, mood, and energy levels. As a dietary supplement, pregnenolone is offered as tablets or capsules.

Pregnenolone is a dietary supplement that can be purchased without a prescription. Typically, it is taken as tablets or capsules. When taken as recommended, pregnenolone is generally regarded as safe.

Benefits of Pregnenolone

A hormone called pregnenolone aids in controlling the body's ability to produce other hormones. Progesterone, testosterone, and estrogen are all precursors to it. Age-related hormonal imbalances may be a result of decreased pregnenolone levels. Some people's memory and cognitive function have been shown to improve with pregnenolone supplementation. Additionally, it might enhance wellbeing, mood, and energy levels.

Memory and Cognition:

Some people's memory and cognitive function have been shown to be enhanced by pregnenolone. Pregnenolone supplementation improved memory in healthy adults between the ages of 60 and 85, according to one study. Pregnenolone improved working memory and reaction time in healthy young adults, according to a different study.

Mood and Energy Levels:

It has also been demonstrated that pregnenolone increases energy and mood. Pregnenolone supplementation improved fatigue and lowered stress in healthy medical students during exam time, according to one study. Pregnenolone increased menopausal women's energy levels and general wellbeing, according to another study.

Safety and Side Effects

When taken as recommended, pregnenolone is generally regarded as safe. However, adverse effects could happen. They consist of fatigue, headaches, and nauseousness. Consult your healthcare provider and stop taking the supplement if you experience any side effects.

Dosage and Supplementation

Pregnenolone is a dietary supplement that can be purchased without a prescription. Typically, it is taken as tablets or capsules. The suggested daily dose is 10–50 mg. It is best to take pregnenolone with food.

Consult your doctor before beginning a pregnenolone supplement if you're thinking about it. Supplements may not be suitable for everyone and can interact with medications.

Pharmacokinetics

Pregnenolone is well absorbed from the gut and rapidly metabolized in the liver. The half-life is approximately 1 hour.