Avanafil vs Sildenafil Citrate

What’s covered?

The drugs Avanafil (Stendra) and Sildenafil (Viagra) are used to treat ED. They are phosphodiesterase-5 inhibitors, a class of FDA-approved prescription drugs (PDE5 inhibitors). Cialis (tadalafil) and Levitra are two more erectile dysfunction medicines in this family (vardenafil).

PDE5 inhibitors function by raising nitric oxide levels as well as activity. They increase blood flow to the penis, resulting in a penile erection. The drugs also aid in boosting sexual satisfaction and sustaining erections. It's vital to remember that PDE5 inhibitors are only effective when combined with sexual stimulation.

Which Medication Is More Effective?

One of the most appealing aspects of Stendra is how rapidly it works, frequently within 15 minutes after ingestion. It is a PDE5 inhibitor that treats erectile dysfunction. There are presently no generic versions of Stendra available for purchase since it is a new drug that was just recently approved by the FDA.

Stendra is available in three different doses: 50mg, 100mg, and 200mg. The efficacy and safety of 100mg and 200mg pills usually take 15 minutes to begin working, so you may take them just before you want to have satisfactory sexual performance. The lesser 50mg dosage usually starts functioning within 30 minutes.

As a result, Stendra is the quickest-acting erectile dysfunction therapy now available. The significant difference of Stendra is typically the best option if you're searching for a pill that works swiftly, successful intercourse attempts, and may be taken shortly before sexual intercourse.

On the other hand, Viagra (sildenafil citrate) and other medications containing sildenafil (generic Viagra) usually take effect in roughly one hour. It implies that you'll take the medication before successful intercourse, which means you'll have to take it sooner than Stendra.

Cialis (tadalafil) and Levitra (vardenafil) are similar in that they take about an hour to have full action in the body.

Which Drug Lasts The Longest?

Because Stendra has a slightly longer half-life than Viagra (sildenafil citrate), each tablet treats erectile dysfunction for an extended time than an equal dosage of Viagra.

Stendra's active component, avanafil, has a terminal half-life of around five hours, which means it takes five hours to achieve half of its initial concentration in the body. The usual medicine dosage delivers six hours of treatment for erectile dysfunction.

It's typical for Stendra to grow less effective as time goes on, just like other ED drugs. As a result, it's better to take the prescription just before you want to have sexual intercourse or sexual activity.

The usual effects of Stendra will last for roughly six hours after you've taken it.

The active component of Viagra (sildenafil) has a four-hour half-life. Generic sildenafil delivers treatment for erectile dysfunction for three to five hours at the usual dosage. One to two hours after taking Viagra, the effects are generally most visible.

Both Stendra (Avanafil) and Viagra (Sildenafil) are ED medications with a short half-life. They are erectile dysfunction medications that have a comparative review. Cialis, also known as tadalafil, may stay in the body for up to 36 hours and give a longer-acting treatment of erectile dysfunction, making it preferable to treat erectile dysfunction for many days. The efficacy rates of tadalafil with only one dose and on-demand were similar.

Which Medication Is More Effective for Erectile Dysfunction?

In a clinical trial, both avanafil (the active component in Stendra) and sildenafil (the active ingredient in Viagra) were shown to be particularly successful in treating erectile dysfunction.

Even though Stendra is a relatively new medicine, it has been supported by multiple massive clinical trials of men with ED. Also, you may rely upon your professional medical advice. Researchers discovered that the comparative effectiveness of avanafil in elderly and younger adults, the active component in Stendra, is "effective and well-tolerated" as an erectile dysfunction medication in a 2012 trial.

In this research, men who took medicine at 100mg or 200mg had a substantial improvement in erectile function, a scoring system used to measure erection quality. In nearly 80% of the cases, both medicines caused erections strong enough to accomplish a successful vaginal penetration in less than 20 minutes.

Similar results have been found in other Stendra clinical trials. Researchers discovered that the efficacy and safety of males with erectile dysfunction who took avanafil improved the quality of their erections at all doses, from the lowest 50mg dose to the highest 200mg pill, in a 2014 clinical evaluation.

In brief, Stendra is successful in treating male sexual dysfunction, with large-scale trials confirming its clinical efficacy.

The Phase III clinical trial indicates Viagra's efficacy and safety rates as an erectile dysfunction medication. Researchers discovered that sildenafil, the main component in Viagra, is an "effective, well-tolerated medication" for men with ED in a 1998 trial.

Additional Viagra (sildenafil citrate) research has had similar findings. In a clinical analysis published in 2002, researchers found that over 95% of men who took sildenafil for one to three years were happy with the treatment's impact on penile erection.

In summary, both Stendra and Viagra are very effective male erectile dysfunction therapies. Even though some users prefer one medicine over the other medications, some medical journals indicate that both work effectively for boosting sexual desire and sexual activity.

Which Drug Has The Fewest Side Effects?

Both Avanafil and Sildenafil have the potential to induce comparable adverse events. Stendra, on the other hand, seems to cause fewer particular adverse events in males than Viagra, such as headaches, lower blood pressure and nasal congestion.

The most prevalent negative effect of both drug interactions is headaches. According to FDA study data, 10.5 per cent of men use Stendra at the maximum recommended dosage. Few men who take 50 mg and 100 mg of Stendra experience headaches.

Headaches are reported by around 28% of men who take Viagra at the maximum prescription dosage, making this a nearly three-fold more prevalent adverse effect for Viagra users.

Other side effects follow a similar pattern. Both Stendra (Avanafil) and Viagra (Sildenafil) cause facial flushing as a side effect. But, it only affects 4.3 per cent of men who take the maximum recommended dosage of Stendra, compared to 18 per cent of men who take the highest recommended dose of Viagra.

Likewise, adverse symptoms such as nasal congestion, indigestion, and back discomfort are more prevalent with using Viagra than with Stendra.

Viagra users commonly reported adverse effects, including vision problems and muscle aches, than Stendra users. Stendra is less likely to create adverse effects by suppressing PDE1, PDE6, or other enzymes since it only targets the PDE5 enzyme.

Drug interactions for treating high blood pressure and other cardiovascular disorders (including multiple sclerosis and spinal cord injury) include Avanafil and Sildenafil. Nitrates, in particular, should not be taken in conjunction with any ED drugs.

In this extensive reference on Stendra (avanafil) side effects, you can discover more about the drug's intolerable adverse effects, such as the particular risk of every side effect occurring.

Drug Interactions of Avanafil and Sildenafil

Patients on nitrate drugs, such as nitroglycerin, must never be used by patients on Stendra or Viagra. Because of the risk of very low blood pressure, the two drugs should never be taken at the same time.

There are a number of medicines that, when used with Stendra or Viagra, may lower blood pressure. Alpha-blockers (including alfuzosin, terazosin, or tamsulosin), riociguat (a medicine used to treat hypertension), and blood pressure drugs are all examples of these. These ED medications should only be used with Stendra or Viagra with care and under the supervision of your healthcare professional.

Enzymes assist drugs are being digested, and one of the most popular is the cytochrome P450 3A4 (CYP3A4) system. A medicine that inhibits CYP3A4 may cause another drug to build up in the system by limiting or slowing down how another medication is digested. If drug A inhibits drug B, for instance, drug B will build up in the body, perhaps leading to greater negative effects. High inhibitors and moderate inhibitors are two types of drugs.

Patients who are on a strong 3A4 inhibitor should not use Stendra, and those who are taking a moderate inhibitor must take no more than 50 mg if their doctor approves. When administered with a powerful 3A4 inhibitor, Viagra must be begun at the lowest dosage of 25 mg. If used with the enzyme inhibitor ritonavir, Viagra must be taken in 25 mg increments at least 48 hours apart.

Other drug interactions may occur; for a complete list of drug interactions, contact your healthcare professional.

Which ED Medication Is The Most Secure?

Erectile dysfunction drugs are typically considered safe for most persons who are otherwise healthy enough to engage in sexual activity, according to the medical profession.

There are possible negative effects to using this drug, just as there are with any other prescription. Certain drugs, such as nitrates, may interact with erectile dysfunction tablets.

When combining alpha-blockers plus erectile dysfunction medicine, those with urinary issues should wait 4 hours.

Moreover, both Avanafil (Stendra) and Sildenafil (Viagra) are PDE5 inhibitors, which are employed in the treatment of erectile dysfunction. They are both very safe drugs when used as directed. You may safely take either medicine as recommended by your wellness professionals if you are a healthy person with no history of cardiovascular disease, high blood pressure, or other heart-related conditions.

Both erectile dysfunction drugs are not available over the counter but only by prescription, so you'll have to talk to a healthcare professional before taking Stendra or Viagra.

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