Vitamin K is rapidly becoming a hot topic in the health and wellness world for its part in blood coagulation, bone health and heart health. This vital nutrient is standard within foods such as leafy greens and fermented products, but people tend to supplement for a more potent, more stable dose. By 2025, new supplement formulations offer a wide variety of high-quality vitamin K products to meet individual health needs.
If you want to get your hands on the best vitamin K supplements of the year, read on as we review the top vitamin K supplements in 2025.
What are the Various Forms of Vitamin K?
Vitamin K exists in two primary forms:
1. Vitamin K1 (Phylloquinone): K1 is present in plant sources such as kale, spinach, and broccoli, but most notably, it is involved with activating clotting factors in the liver and proper blood clotting.
2. Vitamin K2 (Menaquinones): K2 is found in foods consumed commonly, such as animal products and fermented, and it provides broader kinds of benefits, including in calcium metabolism and arterial health. K2 is further divided into subtypes, the most notable being:
· MK-4: An absorption and half-life shorter than short staphylopentaenoic acid menaquinone (SMAQ).
· MK-7: A menaquinone with a long chain that is also highly bioavailable and, therefore, the preferred form of supplication.
What are the Health Benefits of Vitamin K?
1. Bone Health
Vitamin K works hand in hand with calcium, vitamin D, and numerous other nonvitamin antioxidants to help maintain bone density. Instead, it activates osteocalcin, a protein that binds calcium to bone tissue. The research shows a link between higher vitamin K intake and a reduced risk for fractures, with a more significant effect when postmenopausal women consume vitamin K. Half of all women and one in five men over age 50 have low bone density or osteoporosis, putting them at risk of fractures, meaning over 54 million people need nutrients like vitamin K.
2. Cardiovascular Health
Matrix Gla-protein (MGP) inhibition of calcium deposition in arteries is prevented by K2 activity. This has led to studies that diets high in K2 lower cardiovascular mortality by up to 50%. Cardiovascular diseases are the number one killer in the U.K., killing more than 1 in 4 persons.
3. Blood Clotting
Prothrombin and other clotting factors are synthesised in the immune system by vitamin K. It's a significant deficiency and can cause excessive bleeding in people taking anticoagulant therapy. Vitamin K deficiency is common in the community at 3–10% rates, owing to dietary insufficiencies or medical conditions interfering with fat absorption.
4. Cognitive and Neurological Benefits
Research is emerging that shows that vitamin K2 may help with brain health. K2 uses could include the prevention of neurodegenerative disorders through its action of reducing oxidative stress and inflammation.
Vitamin K Supplement- How to Choose the Best?
Selecting the right vitamin K supplement involves several factors:
· Formulation: Supplements containing K1 and K2 are more comprehensive, so look for them.
· Potency: Make sure that the dosage purpose matches your exact health goals. Low-dose supplements are sufficient for general health, but higher quantities are required for therapeutic benefits.
· Synergistic Nutrients: In supplements, vitamin K with vitamin D or magnesium increases the absorption and efficacy.
· Bioavailability: Its extended half-life (allowing for consistent blood levels) makes MK-7 the preferred product.
· Third-Party Testing: Buy for purity, potency and free of contaminants.
Top Vitamin K Supplements of 2025
1. Life Extension Super K
Life Extension Super K is the most comprehensive high-potency multivitamin K supplement we've reviewed. It’s specifically created for individuals aiming for maximum bone, cardiovascular, and overall metabolic health benefits. This supplement includes all three key vitamin K, K1, MK-4, and MK-7 forms to provide complete spectrum support.
Key Ingredients and Dosages:
· Vitamin K1 (Phylloquinone): 2600 mcg
· Vitamin K2 (MK-4): 1000 mcg
· Vitamin K2 (MK-7): 200 mcg
Unique Features:
· Complete Vitamin K Profile: This product combines the advantages of K1 with K2 in terms of its extended metabolic and cardiovascular benefits.
· Advanced Formulation: Both uses of MK-4 and MK-7 provide an immediate and sustained release for short and long-term needs.
· High Potency: It has higher than regular doses to solve issues of people lacking specific health issues, including osteoporosis, arterial calcification, or postmenopausal bone loss.
Benefits:
Bone Health:
Vitamin K contributes to bone metabolism by turning on the protein needed to bind calcium to bone, osteocalcin. Vitamin K intake has been studied, and it’s been shown that those with higher levels of that vitamin suffer fewer fractures. Of course, Life Extension Super K’s high dosage of MK-4 and MK-7 makes it even more effective for preserving bone density.
Cardiovascular Health:
In this supplement, MK-7 prevents the deposition of calcium not only in the skin but also in artery walls, blocking arterial calcification through matrix Gla protein (MGP) activation. According to research, having enough vitamin K2 may reduce the risks of cardiovascular disease by half.
Enhanced Blood Clotting:
Vitamin K1 is essential to producing clotting factors in the liver, including prothrombin. It properly coagulates the blood and avoids over-bleeding.
Extended Bioavailability:
MK7’s long half-life means it’s active in your body for up to 72 hours, resulting in ongoing benefits. One of its advantages is that it benefits those who may not take their doses occasionally.
Safety and Considerations:
Most users can take this supplement without any ill effects. But people who are taking anticoagulants, like warfarin, should speak to a healthcare provider about the potential interactions.
2. Klaire Labs Multithera Vitamin K
Klaire Labs Multithera Vitamin K combines vitamin K2 (MK-7), vitamin D3, and magnesium in a carefully blended form, using a holistic approach to supplementation. It’s perfect for individuals who want to maximise bone health, cardiovascular performance and metabolic support in a single, multi-nutraceutical supplement.
Key Ingredients and Dosages:
· Vitamin K2 (MK-7): 500 mcg
· Vitamin D3: 2000 IU
· Magnesium: 100 mg
Unique Features:
· Synergistic Nutrient Profile: Magnesium and vitamin D3 include the bioavailability and efficacy of vitamin K2.
· Specialised Support: This product is particularly effective in treating osteoporosis, magnesium, and vitamin D.
· Targeted Bone Health Formula: These nutrients support bone density and calcium metabolism.
Benefits:
Cardiovascular Protection:
MK-7 Vitamin K2 prevents arterial calcification, so calcium clings to bones rather than soft tissues. It’s healthier than that, as it reduces the risk of arterial stiffness and cardiovascular disease.
Metabolic Benefits:
Over 300 enzymatic reactions involve magnesium, more than one of which involves energy metabolism. Klaire Labs Multithera Vitamin K is a good source for people with chronic fatigue or metabolic disease due to this fact.
Immune Support:
Vitamin D3 is thought to have immune-modulating properties that can reduce inflammation and act to support the body’s defence mechanisms.
Safety and Considerations:
It's generally safe, but people with kidney disease or hypercalcemia should take it with caution because of the risk of calcium overload.
3. Life Extension Vitamin D and K
Life Extension Vitamin D and K include two key nutrients—vitamin D3 and vitamin K—working to maintain healthy bones and heart. Because this is a synergistic formulation, it simplifies supplementation for those seeking the best calcium metabolism optimisation.
Key Ingredients and Dosages:
· Vitamin D3: 5000 IU
· Vitamin K1: 1000 mcg
· Vitamin K2 (MK-7): 200 mcg
Unique Features:
· Dual Nutrient Approach: Absorption enhances the properties of vitamin D3 with calcium-directing properties of vitamin K.
· Optimal Dosage: Clinically relevant doses that are offered to offer remedies to deficiencies and provide therapeutic benefits.
· Convenient Form: A single capsule can give you nutrients in one powerful shot.
Benefits:
Improved Muscle Function:
Vitamin D is enough to keep muscles strong and decreases the risk of falls in older adults.
Immune Regulation:
This Supplement will also help modulate immune responses and thus is particularly beneficial for people with autoimmune conditions or chronic inflammation.
Safety and Considerations:
You should take vitamin D carefully, especially at high doses, as excessive amounts can cause hypercalcemia. Use only if you take calcium supplements or anticoagulants; consult a healthcare provider before use.
4. Thorne Research Vitamin K2
Thorne Research Vitamin K2 is a form of vitamin K2 that concentrates on the short-chain MK4. The idea is to absorb it quickly, especially if someone has an acute need for vitamin K.
Key Ingredients and Dosages:
· Vitamin K2 (MK-4): 1 mg (1000 mcg)
Unique Features:
· Single Nutrient Focus: This supplement has targeted its support to those deficient or with special needs by offering only MK-4.
· Rapid Action: Bodies use MK–4 quickly and effectively, which means it can offer immediate benefits.
· Pure Formulation: With no other ingredients added to them, this is a clean and potent product.
Benefits:
Neuroprotective Properties:
Recent research indicates that MK-4 may have antioxidant and anti-inflammatory properties and may have beneficial effects on brain health.
Hormonal Balance:
Numerous individuals believe MK 4 supports testosterone production and also supports overall hormonal health, which is unique to what you’re looking for when it comes to testosterone.
Safety and Considerations:
Thorne Research Vitamin K2 is typically well received and considered generally safe; however, it is suggested for those on anticoagulant therapy as it is under medical supervision.
5. NOW Foods MK-7
Affordable and easy to take, NOW Foods MK7 ranks as a good supplement for anyone looking to benefit from vitamin K2. Rather than relying on an artificial juice extracted from laboratory cells, NattoVital™ contains MK-7 derived from fermented chickpeas—providing a clean, natural, non-GMO source of that form of vitamin K2.
Key Ingredients and Dosages:
· Vitamin K2 (MK-7): 100 mcg
Unique Features:
· Fermented Source: This supplement contains a vitamin K2 form made through a fermentation process with chickpeas, so you know you’re getting pure, powerful vitamin K2.
· Non-GMO and Allergen-Free: This product is free of common allergens, such as synthesised soya, gluten, and dairy, whereas others cannot consume it due to dietary restrictions.
· Budget-Friendly: High-quality K2 supplementation is now available to a broader audience due to the competitively priced NOW Foods MK-7.
Benefits:
Extended Bioavailability:
Because MK-7’s half-life is long, the vitamin stays active in the bloodstream for 24 hours or longer, providing steady-state benefits. Due to its extended duration, it is also effective when used in this extended activity for bone and cardiovascular health.
Bone Health:
Vitamin K2 activates osteocalcin, a protein that binds calcium to the bone matrix. Some 10 million European older than 50 have osteoporosis, but vitamin K2 supplementation can be a significant tool in helping to reduce fracture risks by enhancing bone density, according to the CDC.
Cardiovascular Support:
MK-7 activates matrix Gla-protein (MGP) that prevents arterial calcification by stopping calcium deposits in arterial walls. The CDC reports that heart disease still kills more people in the U.k. annually than any other disease — more than 695,000 people in 2014. Mk7 intake can be consistent to maintain good cardiovascular health.
Natural and Clean Formulation:
This supplement, which comes from fermented chickpeas, is made from ferment, not synthetic additives, and is, therefore, a safe and natural thing to use long-term.
Who Should Use It?
NOW Foods MK-7 is ideal for:
I. It is for those trying to avoid osteoporosis or improve bone health.
II. Those with cardiovascular issues who seek an all-natural supplement to support arterial health.
Safety and Considerations:
It is generally well tolerated. However, there are interactions to be concerned about if one is taking an anticoagulant like warfarin, so they should check with their healthcare provider before use.
6. Doctor’s Best Natural Vitamin K2 with MenaQ7
Doctor’s Best Natural Vitamin K2 is superiorly absorbed and efficacious through a clinically validated form of MK-7 (MenaQ7). This supplement is recognised for its long-lasting effect and is rated as one of the most trusted supplements by health professionals and enthusiasts.
Key Ingredients and Dosages:
· Vitamin K2 (MK-7, MenaQ7): 100 mcg
Unique Features:
· Patented Formulation: MenaQ7 is a unique natural form of MK-7 that has been very well studied for its role in helping to support bone and cardiovascular health.
· Superior Bioavailability: The patented process behind MenaQ7 means it is absorbed more efficiently than regular MK-7s.
· Long-Lasting Effectiveness: Due to MK-7’s longer half-life, we created a single dose that offers sustained benefits for up to 72 hours.
Benefits:
Clinically Proven Efficacy:
Many clinical studies involving MenaQ7 prove it can increase bone density, decrease fracture risk, and prevent arterial calcification. Studies have shown that osteoporosis affects 20% of women and 5 per cent of men 50 years of age and over and that evidence-backed supplements like this can be essential to treating such issues.
Improved Cardiovascular Health:
The CDC reports that heart disease — which causes more than 1 in 4 deaths in the U.K. — is a significant risk factor for arterial calcification. The product MenaQ7 activates MGP, a protein that inhibits calcium buildup in arterial walls, increases vascular elasticity and decreases cardiovascular risk.
Bone Health Optimisation:
MenaQ7 encourages the activation of osteocalcin to ensure all that calcium goes to bones. It is essential to keep the bones strong and healthy and lower the risk of breaking bones.
Convenience and Precision:
By being once daily dosed and precise as to strength at 100 mcg, it’s easy to incorporate into daily routines while ensuring optimal vitamin K2 levels.
Who Should Use It?
Doctor’s Best Natural Vitamin K2 is perfect for:
I. Individuals looking for a clinically verified vitamin K2 supplement.
II. People with osteoporosis, osteopenia or similar bone disorders.
III. Individuals who want to avoid or gear up for cardiovascular issues depend on arterial calcification.
Safety and Considerations:
Use is generally safe, but individuals on anticoagulant therapy should consult with a doctor before use. Moreover, optimal results require a balance of calcium and vitamin D.
7. Complete Spectrum Vitamin K by Nutricology
Containing MK-4 and MK-7 as well as K1, Nutricology Full Spectrum Vitamin K is a broad-spectrum vitamin K for anyone requiring such support.
Key Ingredients and Dosages:
· Vitamin K1: 1000 mcg
· Vitamin K2 (MK-4): 500 mcg
· Vitamin K2 (MK-7): 100 mcg
Benefits:
· Comprehensive Coverage: It includes all significant forms of vitamin K for diverse health needs.
· Synergistic Effects: K1 and K2 will ensure the optimal activation of clotting and calcium-regulating proteins.
· Targeted Support: Good for those with layered bone, heart, and blood health issues.
Why It’s Popular?
It is versatile, and for those searching for an all-encompassing vitamin K supplement, it is a go-to.
8. Carlson Labs Vitamin K2
Of many options, Carlson Labs Vitamin K2 with MK-7 is the most straightforward option. Made for folks who prioritise cardiovascular and bone health.
Key Ingredients and Dosages:
· Vitamin K2 (MK-7): 45 mcg
Benefits:
· Bone and Heart Benefits: MK-7 helps maintain calcium metabolism for strong bones and flexible arteries.
· Cost-Effective: Offers a reliable dose of K2 without extra ingredients and, thus, low costs.
· Trusted Quality: Carlson Labs is well known for its rigorous and stringently strict quality standards & sourcing practices.
Why It’s Popular?
Its simplicity and low cost earmark this product as the product of choice for individuals who wish to maintain their overall health without undue extras.
Dosage Guidelines
General Recommendations
· Adults: For men, this is 120 mcg/day, and for women, 90 mcg/day (Dietary Reference Intake).
· Therapeutic Use: Medical supervision may be required for higher doses of 20 mg at a time and 40 mg at the same interval for osteoporosis or arterial calcification.
Safety and Precautions
· Drug Interactions: Anticoagulants like warfarin may need to be avoided because of the problems associated with vitamin K. Supplementation should be consulted with a healthcare provider.
· Tolerability: It is generally well tolerated, although excessive doses may cause adverse effects, especially in clotting disorders.
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