Eicosapentaenoic Acid

An omega-3 fatty acid with numerous health advantages is eicosapentaenoic acid (EPA). Oily fish like salmon, mackerel, and sardines naturally contain it. EPA is produced in a lab and used in dietary supplements and food items.
Overview
Uses
Side Effects
Medication
Ingredients
Supplements
Pharmacokinetics

Health Benefits of Eicosapentaenoic Acid

EPA is renowned for reducing inflammation. This implies that it may lessen the symptoms of ailments like asthma and rheumatoid arthritis. By lowering blood pressure and cholesterol levels, EPA is thought to be good for heart health. EPA has also been demonstrated to enhance brain function and to guard against cognitive decline.

Possible Side Effects of Eicosapentaenoic Acid

EPA is typically regarded as safe, with few side effects having been noted. However, there is a chance that EPA could interact with some drugs, including blood thinners and antidepressants. It is crucial to consult your doctor before taking EPA supplements if you are currently taking any medications.

Mechanism of Action

The precise way that EPA works is not fully understood. But it's believed to function by lessening body inflammation. The production of inflammatory chemicals may be decreased or the production of anti-inflammatory chemicals may be encouraged.

Dosage and Preparation

There are liquid, tablet, and capsule forms of EPA supplements. The dosage that should be used depends on the illness being treated. A dosage of 1-3 grams per day has been recommended for heart health. A daily dosage of 200–400 milligrams has been recommended for brain health. EPA must be consumed with food.

Who Should NOT Take This Supplement?

People who are allergic to fish or shellfish shouldn't take EPA. Before taking this supplement, it is important to talk to your doctor because EPA may also interact with some medications.

Pharmacokinetics

The liver processes EPA after it is quickly absorbed from the gut. EPA has a half-life of about 12 hours.

Interactions

Certain medications, including blood thinners and antidepressants, may interact with EPA. It is crucial to consult your doctor before taking EPA supplements if you are currently taking any medications.

Pregnancy and Breastfeeding

EPA is not advised for use by women who are pregnant or nursing because there is insufficient data to determine its safety in these groups.

Overdosage and Toxicity

EPA does not exist in toxic doses. Omega-3 fatty acid supplementation at extremely high doses, however, may result in loose stools and gastrointestinal discomfort.

Alternatives to Eicosapentaenoic Acid

No dose of EPA has ever been known to be toxic. High doses of omega-3 fatty acids, however, may result in loose stools and gastrointestinal discomfort.

Is alpha-linolenic acid more effective than eicosapentaenoic acid for the treatment of dry eye disease ?

A 2019 systematic review and meta-analysis found that EPA (but not DHA or ALA) was associated with a significant reduction in the severity of dry eye symptoms when compared to no treatment or placebo. According to the authors, EPA's anti-inflammatory properties may be what give it its therapeutic effects.