Relafen

A nonsteroidal anti-inflammatory drug (NSAID) is Relafen (nabumetone). Nabumetone functions by lowering hormones that lead to pain and inflammation in the body.Relafen is used to treat menstrual cramps, rheumatoid arthritis, osteoarthritis, and mild to moderate pain.Users of Welzo can use this article for informational purposes to better understand Relafen.
Overview
Uses
Side Effects
Medication
Ingredients
Supplements
Pharmacokinetics

Health Benefits

In order to treat the following medical conditions, relafen may be used:

Osteoarthritis

arthritis rheumatoid

Period cramps

mild to moderate discomfort

There are additional uses for relafen besides those covered in this medication guide.

Side Effects

Typical negative effects could be:

stomach discomfort, heartburn;

fatigue and a headache;

diarrhea, gas, and bloating

vomiting and/or nausea

skin rash or itching.

There may be additional side effects; this is not a comprehensive list. For medical advice about side effects, contact your doctor.

Dosage

The usual dose for adults is 500 mg twice per day.If more dosage is required, it may be increased up to a daily maximum of 2000 mg in divided doses.1000 mg once or twice daily is the typical adult starting dose for the treatment of osteoarthritis.1000 mg once daily is the typical adult starting dose for the treatment of rheumatoid arthritis.

Interactions

Any potential drug interactions may already be known to your doctor or pharmacist, who may be keeping an eye out for them.Never begin, stop, or alter the dosage of any medication without first consulting your doctor, healthcare provider, or pharmacist.

Pharmacokinetics

The gut quickly and almost entirely absorbs napumetone. In the liver, it goes through a lot of first pass metabolism to create 6-methoxy-2-naphthylacetic acid (6-MNA), which is its main active metabolite. 1-2 hours after an oral dose, nabumetone and 6-MNA both reach their peak plasma concentrations. Both substances have a strong (>99%) affinity for plasma proteins. Nabumetone has a 14–18 hour elimination half life, whereas 6-MNA has a 40–60 hour elimination half life. 10% of a dose is excreted in the feces and 60% of a dose is excreted in the urine as conjugates of nabumetone or 6-MNA.

Mechanism of Action

Nabumetone's exact mode of action is not known. However, it is believed that it works similarly to other NSAIDs by inhibiting COX-1 and COX-2 cyclooxygenases. Compared to other NSAIDs currently on the market, napumetone has a stronger affinity for COX-2.

Nabumetone has anti-inflammatory, antipyretic, and pain-relieving effects. The medicine prevents platelet aggregation as well. All of these steps work to reduce arthritis-related pain and inflammation. Nabumetone distributes easily throughout body tissues because it binds to albumin only weakly.