Vitality Pro NMN vs Welzo Ultra Purity

Medically reviewed by Dr Zeeshan Afzal | Last updated: July 2026 | Reading time: approximately 12 minutes

If you are comparing Vitality Pro NMN vs Welzo Ultra Purity, you are almost certainly asking one of three questions: which one gives you a genuinely research-relevant dose, which one can actually prove its purity, and which one costs less per gram of nicotinamide mononucleotide. This guide answers all three using the published specifications of both products, the human clinical trial literature on NMN, and the UK regulatory position as it stands in 2026.

Both are legitimate UK-facing NMN products from established brands. They are not, however, built the same way. Vitality Pro sells a 250 mg delayed-release capsule in a 90-capsule bottle and asks you to build your own dose from two to four capsules. Welzo Ultra Purity NMN Pro 1000 delivers a fixed 1,000 mg in a two-capsule serving with 30 servings per bottle. That single structural difference drives almost every other difference in this comparison — dose flexibility, capsule count, and above all cost per gram.

For the underlying science on how this molecule works, start with our pillar guide to NMN benefits, side effects and dosage, browse the full range in Welzo NMN supplements, or read our standalone Vitality Pro NMN review.

Table of Contents

• Quick verdict: Vitality Pro NMN vs Welzo Ultra Purity
• What each product actually is
• Dose: 250 mg capsules vs a 1,000 mg serving
• Purity: what "ultra purity" and "99% pure" really mean
• Capsule technology, excipients and fillers
• Cost per gram: the number that decides it for most people
• Timing, absorption and stacking
• Safety, side effects and who should not take NMN
• UK regulatory status of NMN in 2026
• Which should you choose?
• How we compared these products
• Frequently asked questions
• References

Quick verdict: Vitality Pro NMN vs Welzo Ultra Purity

If you want the short answer: Welzo Ultra Purity NMN Pro 1000 is the better value and the simpler product for anyone targeting a 1,000 mg daily dose, because it delivers that dose in two capsules for £26.99 a month. Vitality Pro NMN is the better choice if you want fine dose control in 250 mg steps, a delayed-release capsule, or a brand-name ingredient with a long public batch-testing archive, and you are willing to pay a significant premium per gram for it.

Prices were checked in July 2026 and change frequently. Vitality Pro's figure has been converted from the US dollar price displayed on its own product page; check the live GBP price before buying. If price is your deciding factor, our guides to the cheapest NMN in the UK and what a longevity stack actually costs put both products in wider context.

What each product actually is

Vitality Pro NMN

Vitality Pro is a Dorset-based UK longevity brand selling single-ingredient supplements. Its flagship NMN product contains 250 mg of β-nicotinamide mononucleotide per delayed-release capsule, with 90 capsules per standard bottle and larger 180 and 720-capsule options. The brand recommends two, three or four capsules daily on an empty stomach in the morning — 500 mg, 750 mg or 1,000 mg respectively.

The product uses Uthever®, a branded NMN raw material produced by enzymatic synthesis. Vitality Pro states that manufacturing is carried out to GMP standards under ISO 9001:2015 quality management, and that each batch is independently tested by an ISO/IEC 17025-accredited laboratory. Its batch-testing page publishes assay results going back to 2019, with reported purity figures consistently at or above 99%.

Welzo Ultra Purity NMN Pro 1000

Welzo Ultra Purity is Welzo's own-brand, purity-first supplement line. NMN Pro 1000 provides 1,000 mg of nicotinamide mononucleotide per two-capsule serving, with 30 servings (60 capsules) per bottle. The only other ingredients are the HPMC vegetable capsule shell and vegetable magnesium stearate — there are no botanical blends, no proprietary complexes and no bulking agents beyond the flow agent.

Every batch undergoes independent third-party testing for ingredient identity, NMN purity, contaminant screening and batch consistency, and the certificate of analysis is published as a downloadable PDF on the product page rather than being available only on request. That is a meaningful transparency point, and one we explain in more detail in our guide to reading a supplement certificate of analysis.

Dose: 250 mg capsules vs a 1,000 mg serving

This is where the two products genuinely diverge, and it matters more than any marketing language on either label.

What doses have been used in human trials

Published human research on NMN has used daily doses across a fairly wide band. In a 10-week randomised, placebo-controlled trial at Washington University published in Science, postmenopausal women with prediabetes took 250 mg per day and showed improved skeletal muscle insulin sensitivity and insulin signalling compared with placebo [1]. A randomised controlled trial in healthy middle-aged adults compared 300 mg, 600 mg and 900 mg per day over 60 days and reported dose-related increases in blood NAD+ concentrations, with the 600 mg and 900 mg arms performing best [2]. A six-week trial in amateur runners tested 300 mg, 600 mg and 1,200 mg daily alongside training, with the medium and high-dose groups showing greater improvements in oxygen utilisation than control [3]. A separate 12-week trial in older adults used 250 mg daily and looked at sleep quality, fatigue and lower-limb function [4].

Why 500 mg is the usual practical starting point

Taken together, the trial literature does not identify a single optimal dose, but it does show that the studies reporting the clearest NAD+ increases have generally used 500 mg or more per day. That is why most UK brands, including both of the ones compared here, position 500 mg as a floor and 1,000 mg as an upper everyday target. Neither figure is an official recommendation — NMN has no Nutrient Reference Value and no authorised health claim in the UK. For an age-banded breakdown, see our guide to NMN dosage by age.

Which product makes your target dose easier

The practical arithmetic is straightforward:

• Targeting 500 mg/day: Vitality Pro needs two capsules, giving 45 days per 90-capsule bottle. Welzo needs one capsule, giving 60 days per bottle.
• Targeting 750 mg/day: Vitality Pro handles this cleanly with three capsules. Welzo cannot hit 750 mg exactly without splitting doses across days.
• Targeting 1,000 mg/day: Vitality Pro needs four capsules and the bottle lasts 22.5 days. Welzo needs two capsules and the bottle lasts a full 30 days.

If you value the ability to titrate upward in small steps — which is a sensible approach when starting any new supplement — Vitality Pro's 250 mg unit is the more flexible tool. If you already know you want the full gram, Welzo does it in two capsules instead of four, for less than half the money. Our article on how to start longevity supplements covers sensible titration in more depth.

Purity: what "ultra purity" and "99% pure" really mean

Purity is the headline claim on both products, so it is worth being precise about what the word is actually describing.

Beta-NMN versus the alpha anomer

Nicotinamide mononucleotide exists as two anomers, alpha and beta. Only the beta form is the biologically active NAD+ precursor used in human research. A raw material can be 99% "NMN" while containing a meaningful fraction of the inactive anomer if the assay does not distinguish between them. This is why a credible certificate of analysis specifies β-NMN and states the analytical method, usually high-performance liquid chromatography (HPLC). Vitality Pro's label and test certificates specify β-nicotinamide mononucleotide. Welzo's Ultra Purity testing verifies ingredient identity as well as purity level, which is the same principle expressed differently.

Assay, heavy metals and microbiology are three separate tests

A single "99% pure" number tells you about assay only. A complete quality picture requires three things, and a reputable brand will document all of them:

• Assay / potency: how much β-NMN is actually present versus what the label claims.
• Heavy metals: lead, arsenic, cadmium and mercury against defined limits.
• Microbiology: total plate count, yeast and mould, and specified pathogens.

Vitality Pro publishes both analytical and microbiology certificates for each batch, with reported purity results ranging from 99% to figures slightly above 100% (a normal consequence of assay tolerance and reference-standard calibration, not a claim of impossible purity). Welzo publishes a certificate of analysis for its NMN capsules covering identity, purity and contaminant screening. Both approaches are legitimate; Vitality Pro's advantage is the depth of the historical archive, Welzo's is that the certificate is one click away on the product page itself.

What to check on any certificate of analysis

• Is there a batch or lot number, and does it match the number printed on your bottle?
• Is the testing laboratory named, and is it ISO/IEC 17025 accredited?
• Does the certificate test the finished capsule or only the incoming raw powder?
• Is there a date, and is it recent enough to correspond to stock currently on sale?

Our companion guides on third-party tested supplements and supplement fillers explain how to spot the difference between real documentation and quality-flavoured marketing.

Capsule technology, excipients and fillers

Delayed release versus standard HPMC

Vitality Pro uses a delayed-release HPMC capsule, designed to resist dissolution in the stomach and release its contents further down the digestive tract. The rationale is that NMN is a phosphorylated molecule that may be partially degraded by gastric acid, so delaying release could preserve more of the intact compound. This is a plausible mechanistic argument, but it is important to be honest about the evidence: there are no published head-to-head human trials comparing delayed-release NMN capsules against standard capsules for NAD+ outcomes. The successful human trials cited above used conventional oral formulations.

Welzo uses a standard HPMC vegetable capsule — the same format used in the majority of published NMN trials. Neither approach is demonstrably superior on current evidence. The same caveat applies to sublingual NMN and liposomal NMN, both of which are marketed on absorption arguments that outrun the human data.

Microcrystalline cellulose versus magnesium stearate

Vitality Pro's only non-active ingredient is microcrystalline cellulose, a plant-derived bulking agent. Welzo uses vegetable magnesium stearate, a flow agent used in tablet and capsule manufacturing worldwide. Magnesium stearate periodically attracts negative attention online; the quantities used in a capsule are very small and it is a permitted, widely used excipient. Both products avoid artificial colours, preservatives and common allergens, and both use vegan capsule shells.

Cost per gram: the number that decides it for most people

Because the two products contain different total quantities of NMN per bottle, comparing sticker prices is misleading. Cost per gram of NMN is the only fair comparison.

On these figures, running a 1,000 mg daily protocol on Welzo Ultra Purity costs roughly a third of the equivalent Vitality Pro protocol. Vitality Pro's larger 180 and 720-capsule packs narrow the gap and should be factored in if you intend to buy in bulk, and both brands run promotions. The structural point stands regardless: a 250 mg capsule format inherently requires four capsules and more packaging, handling and encapsulation cost per gram delivered than a 500 mg capsule format.

If you are budgeting a wider protocol rather than a single product, see cheap NMN in the UK and why longevity supplements are so expensive.

Timing, absorption and stacking

Morning versus evening

Both brands recommend morning dosing, on the reasoning that NAD+ follows a circadian pattern and supplementation is best aligned with the body's own production cycle. Vitality Pro recommends taking capsules on an empty stomach; Welzo recommends taking two capsules with breakfast. Neither instruction is supported by direct comparative human data, and there is no evidence that one is meaningfully superior. The trial in older adults noted above actually tested morning versus afternoon dosing and reported some differences favouring afternoon intake for certain outcomes [4], which is a useful reminder that this question is not settled.

Our guides on when to take NMN, taking NMN with food and supplements on an empty stomach go into this in more depth.

Do you need TMG alongside NMN?

Converting NMN to NAD+ produces nicotinamide, which the body clears partly through methylation. The theoretical concern is that sustained high-dose NMN could draw on methyl donor pools, and trimethylglycine (TMG) is commonly added to offset this. It is a reasonable precaution rather than an established requirement — no human trial has demonstrated clinically meaningful methyl depletion from NMN supplementation at typical doses. We cover the arguments on both sides in do I need TMG with NMN and TMG vs methylfolate.

Stacking and cycling

Both products are single-ingredient, which makes them easy to build a stack around. If you are combining NMN with resveratrol, TMG or other compounds, see the NMN, TMG and resveratrol stack guide and our overview of which supplements can be taken together. On the question of whether to take breaks, see cycling NMN.

Safety, side effects and who should not take NMN

Oral NMN has a reassuring short-term safety record in the trials conducted so far. A randomised, double-blind, placebo-controlled study gave 1,250 mg of β-NMN once daily for four weeks to healthy adults aged 20 to 65 and found no changes beyond normal physiological variation in haematological, biochemical, urinary or body composition measures, and no severe adverse events [5]. A 2026 systematic review and meta-analysis of oral NMN trials similarly found no significant adverse signal across pooled safety and metabolic outcomes [6].

That said, the trials are short, the participant numbers are small, and long-term data in humans does not yet exist. Reported side effects when they occur tend to be mild and gastrointestinal — nausea, loose stools, or mild digestive discomfort — and often resolve when the dose is lowered or taken with food. Our article on NMN overdose and upper limits covers this in detail.

Do not take NMN, or speak to a clinician first, if you:

• are pregnant, trying to conceive, or breastfeeding
• are under 18
• take anticoagulants, anti-seizure medication, or any medicine where a B3-family compound could interact — the DrugBank entry for NMN is a useful starting reference [7]
• have an active cancer diagnosis or are under oncology care, since NAD+ metabolism interacts with cell proliferation pathways and this has not been resolved in humans
• have significant liver or kidney impairment

NMN is a food supplement, not a medicine. It is not a treatment for any disease, and nothing in this article should be taken as a claim that it prevents, treats or cures any condition. If you are considering stopping, our guide on stopping NMN explains what to expect.

UK regulatory status of NMN in 2026

This is an area of genuine confusion, and it is worth stating plainly. NMN is treated as a novel food in Great Britain, meaning it was not consumed to a significant degree in the UK or EU before 15 May 1997 and therefore falls within the authorisation framework administered by the Food Standards Agency under assimilated Regulation (EU) 2015/2283 [8]. The FSA maintains a public register of authorised novel foods and their conditions of use [9].

The position continues to move. In May 2026 the European Food Safety Authority issued a positive safety opinion on an NMN dossier, proposing a safe daily intake of 300 mg for the general adult population excluding pregnant and lactating women, a step toward formal EU authorisation [10]. Because this landscape changes, check the FSA register directly for the current position rather than relying on any retailer's summary, including ours.

Two practical consequences for buyers. First, there are no authorised health claims for NMN in the UK, so any brand promising specific outcomes is overstepping. Second, availability at high-street retailers has been inconsistent — see NMN at Holland & Barrett, NMN at Boots and NMN on Amazon UK for the current picture, and where to buy NMN in the UK for a broader overview.

Which should you choose?

Choose Welzo Ultra Purity NMN Pro 1000 if

• You want a full 1,000 mg daily dose and want it in two capsules rather than four.
• Cost per gram matters — it is roughly a third of the Vitality Pro equivalent on current pricing.
• You want the certificate of analysis available directly on the product page.
• You want a clean single-ingredient product with no blends, and you are building your own stack around it.
• You want a 30-day bottle that maps neatly onto a monthly routine.

Choose Vitality Pro NMN if

• You want to titrate in 250 mg increments, or intend to run 500 mg or 750 mg rather than a full gram.
• You specifically want a delayed-release capsule and accept that the supporting human evidence is mechanistic rather than clinical.
• You place a premium on a branded raw material and a long, publicly archived batch-testing history.
• You prefer microcrystalline cellulose to magnesium stearate as an excipient.
• You are buying the larger 180 or 720-capsule packs, which materially improve its cost per gram.

Choose neither, for now, if

• You have not yet addressed sleep, resistance training, protein intake and cardiovascular fitness — none of which any capsule replaces. See zone 2 training for longevity.
• You are unsure whether NMN is worth the money at all. Read is NMN a scam and longevity supplements that don't work first — we would rather you skip a purchase than make an uninformed one.

How we compared these products

Every specification in this article was taken from each brand's own published product page and label information, checked in July 2026. Dose, capsule count, excipients and testing claims are reported as the manufacturers state them; we have not independently laboratory-tested either product, and we say so rather than implying testing we did not perform.

Clinical claims are sourced to peer-reviewed human trials, listed in full below. Where a marketing claim is not supported by human evidence — delayed-release absorption, sublingual superiority, the necessity of TMG — we have said so explicitly, including where that is unflattering to a Welzo product. Pricing is volatile and should be verified before purchase. This article was medically reviewed by Dr Zeeshan Afzal for factual accuracy and compliance with UK advertising and health-claim rules. Our full editorial standards are published at how we write.

Frequently asked questions

Is Vitality Pro NMN or Welzo Ultra Purity better value?

Welzo Ultra Purity NMN Pro 1000 is better value on cost per gram. A £26.99 bottle contains 30 g of NMN, working out at roughly £0.90 per gram, falling to about £0.77 per gram on the three-bottle option. Vitality Pro's 90-capsule bottle contains 22.5 g at approximately £58, or roughly £2.58 per gram. Vitality Pro's larger 180 and 720-capsule packs reduce that gap. Prices change, so check both before buying.

Which has the higher dose per capsule?

Welzo. Each Welzo Ultra Purity capsule contains 500 mg of NMN, so a 1,000 mg daily dose takes two capsules. Vitality Pro capsules contain 250 mg each, so the same 1,000 mg dose takes four capsules. Vitality Pro's smaller unit is more flexible if you want to run 500 mg or 750 mg instead.

Is delayed-release NMN better absorbed than standard capsules?

There is no published human trial comparing delayed-release NMN capsules against standard capsules for NAD+ outcomes. The rationale — protecting NMN from stomach acid — is mechanistically plausible, but it is a theory rather than a demonstrated advantage. The human trials that reported increases in blood NAD+ used conventional oral formulations.

What NMN dose does the research actually support?

Published human trials have used daily doses from roughly 250 mg to 1,200 mg. A 10-week trial at 250 mg improved muscle insulin sensitivity in prediabetic postmenopausal women, while a 60-day trial comparing 300, 600 and 900 mg found the largest NAD+ increases at 600 mg and above. There is no official recommended intake for NMN in the UK, and no authorised health claim.

Do both products publish a certificate of analysis?

Yes, but in different ways. Welzo publishes a downloadable certificate of analysis PDF directly on the NMN Pro 1000 product page. Vitality Pro publishes an extensive batch-testing archive with analytical and microbiology certificates for individual batches dating back to 2019. Vitality Pro's archive is deeper; Welzo's is more immediately accessible at the point of purchase.

Is NMN legal to buy in the UK in 2026?

NMN sits within the novel food framework in Great Britain, administered by the Food Standards Agency under assimilated Regulation (EU) 2015/2283. Products remain available from UK retailers, and in May 2026 EFSA issued a positive safety opinion on an NMN dossier proposing a 300 mg daily safe intake for the general adult population. The position is evolving, so check the FSA's register of novel food authorisations for the current status.

Does magnesium stearate in the Welzo product matter?

For the overwhelming majority of people, no. Vegetable magnesium stearate is a permitted flow agent used at very small quantities in capsule manufacturing worldwide. Vitality Pro uses microcrystalline cellulose instead. If you actively avoid stearates, that is a legitimate reason to prefer Vitality Pro, but it is a preference rather than a safety issue.

Do I need to take TMG with either of these products?

Not necessarily. The argument for adding TMG is that clearing the nicotinamide produced during NMN metabolism uses methyl groups, so a methyl donor may offset that draw. No human trial has demonstrated clinically meaningful methyl depletion from NMN at normal doses. Some people take TMG as a precaution, particularly at 1,000 mg or above and over long periods. Discuss it with a clinician if you have a known methylation-related condition.

How long before I notice anything?

Welzo's own guidance suggests some people report changes in energy and focus within two to four weeks, with more consistent effects after eight to twelve weeks of daily use. These are subjective reports rather than trial endpoints, and individual response varies with age, baseline NAD+ status, diet and activity. Some people notice nothing at all. See how long supplements take to work.

Can I switch from Vitality Pro to Welzo, or take both?

You can switch freely — both deliver the same molecule and there is no adaptation period. Do not take both simultaneously without recalculating your total daily intake, since it is easy to double-dose accidentally when one product is 250 mg per capsule and the other is 500 mg. Add up the milligrams, not the capsules, and speak to a clinician if you take any prescribed medication.

References

1. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229. https://www.science.org/doi/10.1126/science.abe9985
2. Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomised, multicentre, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735188/
3. Liao B, Zhao Y, Wang D, et al. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomised, double-blind study. Journal of the International Society of Sports Nutrition. 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265078/
4. Kim M, Seol J, Sato T, et al. Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: a randomised, double-blind, placebo-controlled study. Nutrients. 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877443/
5. Fukamizu Y, Uchida Y, Shigekawa A, et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Scientific Reports. 2022;12:14442. https://www.nature.com/articles/s41598-022-18272-y
6. Safety and metabolism-related outcomes of oral nicotinamide mononucleotide supplementation in adults: a systematic review and meta-analysis. Nutrients. 2026;18(14):2251. https://doi.org/10.3390/nu18142251
7. DrugBank. Nicotinamide mononucleotide (DB03227) — interaction and pharmacology profile. https://go.drugbank.com/drugs/DB03227
8. Food Standards Agency. Novel foods authorisation guidance. https://www.food.gov.uk/business-guidance/regulated-products/novel-foods-guidance
9. Food Standards Agency. Register of novel food authorisations for Great Britain. https://data.food.gov.uk/regulated-products/novel_authorisations/guidance
10. NutraIngredients. EFSA issues positive safety opinion on NMN. May 2026. https://www.nutraingredients.com/Article/2026/05/13/efsa-gives-positive-safety-opinion-on-nmn/
11. Song Q, Zhou X, Xu K, et al. The safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: an update. Advances in Nutrition. 2023. https://www.sciencedirect.com/science/article/pii/S2161831323013595
12. Shade C. The science behind NMN — a stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine. 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/
13. NSF. Good Manufacturing Practice (GMP) certification for dietary supplements. https://www.nsf.org/au/en/nutrition-wellness/gmp-certification
14. Vitality Pro. Product batch testing certificates. https://vitality-pro.com/batch-testing/
15. Welzo. NMN Pro 1000 Ultra Purity — certificate of analysis. https://welzo.com/products/nmn-pro-1000
16. PubMed. Yoshino M, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women (PMID 33888596). https://pubmed.ncbi.nlm.nih.gov/33888596/

Medical disclaimer

This article is for general information and education only and is not a substitute for professional medical advice, diagnosis or treatment. NMN is a food supplement, not a medicine, and is not intended to prevent, treat or cure any disease. There are no authorised health claims for NMN in the United Kingdom. Always speak to your GP, pharmacist or a qualified healthcare professional before starting any supplement, particularly if you are pregnant or breastfeeding, under 18, taking prescription medication, or living with a diagnosed medical condition. Product specifications and prices were accurate at the time of writing and may change; always read the label on the product you receive.

Medically reviewed by Dr Zeeshan Afzal. Read our editorial policy, explore the full Welzo NMN supplement range, or start with our pillar guide to NMN benefits, side effects and dosage.