Best Life Extension Supplements: Expert guide

Selected as a standout “cellular energy” option because PQQ is commonly used in longevity routines to support mitochondrial function and day-to-day energy resilience. Dr Zeeshan Afzal’s testing prioritised tolerability, clean capsule format, and suitability for consistent use.

A targeted PQQ supplement providing 20 mg per capsule in a vegetarian-friendly format. Positioned for people building a longevity stack around energy, cellular support, and healthy ageing foundations.

Typically chosen by users who prefer a single-ingredient longevity supplement with a clear purpose. Feedback commonly focuses on routine compatibility and ease of dosing rather than “overnight” effects, which aligns with how longevity supplements should be evaluated.

£34.45

Life Extension PQQ Caps 20 mg (30 Vegetarian Capsules)

Clear, targeted “cellular energy” positioning

Vegetarian capsule format

Simple to stack alongside other longevity basics

Not a comprehensive formula (single-ingredient focus)

Benefits are usually gradual and routine-dependent

Typically taken once daily with food. For sensitive stomachs, taking it earlier in the day and with a meal can improve comfort. Always follow the product label instructions.

This is the type of longevity supplement that suits people who value clarity: one ingredient, one job. It works best as part of a consistent routine that includes sleep, protein intake, and activity rather than as a “quick fix.”

Selected for methylation and metabolic support relevance. TMG (trimethylglycine) is often used to support methyl donation pathways and is commonly paired with B-vitamins in structured longevity routines. Dr Zeeshan Afzal’s testing favoured predictable dosing and an easy-to-follow capsule format.

Provides 500 mg of TMG per capsule. Frequently used by people aiming to support methylation, homocysteine management strategies (under clinician guidance where appropriate), and overall metabolic resilience.

Users who buy TMG usually do so intentionally—often because they already understand methylation basics. Reviews commonly highlight the convenience of capsules and routine fit, especially when used consistently rather than intermittently.

Life Extension TMG 500 mg (60 Capsules)

Clear methylation support use-case

Simple capsule dosing for consistency

Stacks well with B-complex routines

Not everyone needs methylation support supplements

Best results usually come from structured, long-term use

Commonly taken once daily with food, or as directed on the label. If used alongside B-vitamins, maintain a consistent schedule rather than “on/off” dosing. Follow label guidance.

TMG makes sense for readers who are already building a deliberate longevity routine. It’s not a “feel it immediately” supplement for most people, but it’s a practical foundational tool when used with intention.

Selected because it’s a specialist product that people specifically search for, and it requires careful context. Dr Zeeshan Afzal includes it as a “purpose-led” item rather than a general longevity supplement, because iodine support is highly individual and should not be used casually in high doses.

A high-dose potassium iodide tablet format (130 mg). This type of product is typically purchased for specific preparedness use-cases rather than everyday supplementation. It is not a standard daily iodine supplement.

Buyers tend to review this product based on clarity, packaging, and availability. Most feedback is not about “wellbeing benefits,” because the intended use-case is specialised.

£6.52

Life Extension Potassium Iodide Tablets 130 mg (14 Tablets)

Purpose-specific product with clear dosing format

Convenient tablet count for its intended use-case

Not intended for daily iodine supplementation

High-dose iodine is not suitable for many individuals

Should be used only according to appropriate guidance

Use strictly according to the product label and any official guidance relevant to the intended purpose. This is not a routine “longevity” supplement. If there is any uncertainty, seek professional advice before use.

This is included for completeness because it’s frequently searched and misunderstood. It should not be treated as a daily wellness supplement. For everyday longevity routines, most people should look elsewhere unless there is a clear and appropriate reason to use it.

Selected as a high-impact, purpose-led option often used in mood and liver-support routines. Dr Zeeshan Afzal’s review prioritised the enteric-coated format (commonly chosen for digestion and stability) and suitability for structured use rather than casual, sporadic dosing.

An enteric-coated SAMe (S-adenosylmethionine) product providing 400 mg per tablet in a vegetarian format. Enteric coating is commonly used to help protect sensitive compounds through the stomach.

Reviews typically focus on product quality, tablet format, and consistent effects when used as part of a routine. SAMe is often described as a “structured” supplement—users generally do best when they follow label guidance consistently.

£33.71

Life Extension SAMe 400 mg (30 Enteric-Coated Vegetarian Tablets)

Enteric-coated delivery for stability

Clear, single-purpose formulation

Vegetarian tablets

Not suitable for everyone; interactions are possible

Higher-cost category compared with basics

Best used with careful routine planning

Follow label directions carefully. If the user takes any medication or has a history of mood disorders, professional guidance is recommended before use. Do not combine indiscriminately with other mood-active supplements.

SAMe is not a “casual add-on” in most stacks. The enteric-coated format is a key reason this product stands out. It suits readers who want a focused, high-intent supplement and will follow dosing guidance consistently.

Selected as the vegetarian alternative for users who require that format, while maintaining the same specialist positioning. Dr Zeeshan Afzal includes it to address search demand and to reinforce that high-dose iodine products are not everyday longevity supplements.

A vegetarian tablet version of potassium iodide at 130 mg per tablet. Intended for specific preparedness use-cases rather than daily nutritional iodine intake.

Feedback typically focuses on accessibility and format preference (vegetarian tablets). As with the standard version, reviews are less about “benefits” and more about clarity and availability.

£7.03

Life Extension Potassium Iodide Tablets 130 mg (14 Vegetarian Tablets)

Vegetarian format option

Clear dosing for specialist use

Not appropriate for routine supplementation

High-dose iodine is unsuitable for many individuals

Requires careful use and appropriate guidance

Use only according to label directions and any relevant official guidance. Not intended for day-to-day longevity routines.

This is included because users actively search for a vegetarian option. It remains a specialist product, not a general “anti-ageing” supplement.

Selected because pregnenolone is one of the most commonly discussed hormone-precursor supplements in longevity circles. Dr Zeeshan Afzal’s review focuses on appropriate caution, user suitability, and the importance of avoiding “hormone stacking” without clear rationale.

A pregnenolone supplement designed for adults who are exploring healthy ageing routines. Pregnenolone is a precursor hormone, which is why it should be approached thoughtfully and not treated as a standard daily vitamin.

Reviews often reflect that users choose this product intentionally, typically after researching hormone precursors. Feedback commonly focuses on consistency, perceived “wellbeing support,” and capsule practicality.

£21.78

Life Extension Pregnenolone

Popular “healthy ageing” hormone-precursor category

Simple single-ingredient approach

Often used in structured, goal-led routines

Not suitable for everyone (hormone-sensitive situations)

Not a foundational supplement for most people

Best used with a cautious, informed approach

Follow the product label. Avoid combining with multiple hormone-active supplements without clear guidance. If there is a history of hormone-sensitive conditions or medication use, professional advice is strongly recommended.

This is a “high-intent” longevity product, not a generic wellness add-on. Dr Zeeshan Afzal’s view is that it should only be used when the user understands why they are taking it and is willing to monitor response carefully.

Selected as a specialist men’s healthy-ageing formula because prostate comfort and urinary function are common longevity concerns. Dr Zeeshan Afzal’s testing prioritised comprehensive formulation logic, softgel convenience, and suitability for long-term use.

A prostate-focused softgel formula designed for adult men who want targeted support as part of healthy ageing. Typically positioned for prostate health maintenance and day-to-day urinary comfort support.

Users reviewing prostate formulas often focus on consistency and long-term routine fit. Feedback tends to reflect that benefits—if noticed—are gradual and best evaluated over weeks rather than days.

Life Extension Ultra Prostate Formula (60 Softgels)

Purpose-led formula for men’s healthy ageing

Softgel format can be easy to take

Best suited to consistent, longer-term use

Not relevant for users without prostate-focused goals

As with many botanicals, response can vary

Follow label directions, typically with food. For best evaluation, maintain consistent daily use for several weeks and avoid frequent switching between multiple prostate formulas.

This is a strong “targeted longevity” pick for men who want a prostate-specific option rather than a general multivitamin approach. It suits those who value structured, category-specific support.

Selected as a “liver and recovery” support option because alcohol exposure and oxidative burden are common concerns for modern lifestyles. Dr Zeeshan Afzal’s review focuses on formulation purpose, realistic expectations, and responsible positioning (supporting recovery routines, not “cancelling” alcohol effects).

A capsule-based complex designed to support liver-related pathways and antioxidant systems during periods of alcohol intake. Positioned for people who want a structured support supplement alongside hydration, nutrition, and responsible drinking habits.

Users generally review this type of product based on perceived next-day support and overall routine fit. Feedback often highlights that the best results come when combined with hydration, sleep, and mindful intake.

£33.75

Life Extension Anti-Alcohol with Hepatoprotection Complex (60 Capsules)

Clear “support” positioning for recovery routines

Useful for users who want a structured approach

Convenient capsule format

Not a substitute for responsible alcohol intake

Individual response varies

Follow the label directions. Most users take it around occasions of alcohol intake. Hydration, food intake, and sleep remain the biggest drivers of how someone feels the next day.

One of the better “modern lifestyle” support categories when used responsibly. Dr Zeeshan Afzal’s view is that it should complement healthy habits, not encourage higher alcohol consumption.

Selected as a strong antioxidant-support option because it combines glutathione with supportive precursors and vitamin C, which is commonly used for antioxidant recycling. Dr Zeeshan Afzal’s testing prioritised a formula that makes sense biologically, not just “more ingredients.”

A capsule formula combining glutathione with cysteine and vitamin C to support antioxidant systems. This is typically used by people aiming to support oxidative stress management as part of a longevity-focused routine.

Users generally review glutathione products based on perceived wellbeing support, routine compatibility, and tolerance. Many readers report that the value is in consistent use over time rather than a dramatic short-term “feel.”

£22.41

Life Extension Glutathione, Cysteine & C (100 Capsules)

Co-factor approach (glutathione + support nutrients)

Strong fit for antioxidant-focused longevity stacks

Capsule format supports consistent use

Not everyone needs direct antioxidant supplementation

Benefits are typically subtle and long-term

Typically taken daily with food, following label guidance. For best evaluation, keep use consistent for several weeks and avoid stacking multiple high-dose antioxidant products unnecessarily.

This is a sensible “systems support” formula. Dr Zeeshan Afzal rates it highly for people who want a structured antioxidant approach without chasing trends.

Selected because uric acid management is a common healthy-ageing topic, particularly for mobility and joint comfort goals. Dr Zeeshan Afzal’s review focuses on responsible positioning: it supports nutritional strategies but does not replace clinical evaluation for gout or persistent joint pain.

A targeted uric-acid support supplement in vegetarian capsule format. Typically used by adults exploring dietary and supplement strategies that align with long-term mobility and metabolic wellbeing goals.

Users often review uric-acid products based on routine fit and perceived joint comfort over time. Feedback tends to reflect that outcomes are best when combined with diet changes (hydration, alcohol moderation, reduced purine-heavy intake where relevant).

£20.28

Life Extension Uric Acid Control (60 Vcaps)

Targeted approach for uric acid support goals

Vegetarian capsule format

Fits well into “mobility and metabolic” longevity planning

Not a substitute for medical care in gout or severe symptoms

Diet and hydration often matter as much as supplements

Follow label instructions, typically with food. For best results, pair with consistent hydration and dietary strategies. Seek medical advice if symptoms are severe or persistent.

A useful targeted option for adults thinking about long-term mobility and metabolic markers. Dr Zeeshan Afzal recommends treating it as part of a broader plan rather than relying on a single supplement.

Selected as the strongest “brain ageing” magnesium format in this lineup. Magnesium L-threonate is often chosen for cognitive-focused routines due to its positioning around brain support. Dr Zeeshan Afzal’s testing prioritised tolerability, capsule convenience, and suitability for long-term use.

A magnesium L-threonate formula in vegetarian capsules, commonly used by adults who want cognitive and nervous-system support as part of a longevity strategy, especially when sleep quality and stress load are also being addressed.

Users often describe this category as a “routine enhancer,” particularly when taken consistently. Reviews commonly focus on sleep quality, calmness, and cognitive steadiness, though response varies.

Life Extension Magnesium L-Threonate (Neuro-Mag) (90 Veg Capsules)

Cognitive-focused magnesium format

Vegetarian capsules

Often fits well into evening routines

Typically more expensive than basic magnesium forms

Not everyone needs a specialised format

Commonly taken daily, often later in the day. Follow label directions. If the user is sensitive to magnesium, start low (per label guidance) and assess tolerance.

This is one of the best options for readers prioritising brain ageing and sleep routine quality. Dr Zeeshan Afzal’s view is that the biggest wins happen when it’s paired with stress reduction and consistent sleep timing.

Selected for women who want a targeted healthy-ageing supplement in a category many people actively search for. Dr Zeeshan Afzal’s review prioritises careful language and suitability: hormone-related supplements are not one-size-fits-all and should be chosen thoughtfully.

A women’s health-focused tablet formula positioned for hormonal wellbeing support. Often considered during midlife health optimisation routines, particularly when users want a structured supplement approach.

Reviews in this category tend to focus on perceived wellbeing support and routine compatibility. Users usually evaluate it over several weeks, and experiences can vary widely depending on individual context.

£33.84

Life Extension Estrogen for Women (30 Tablets)

Targeted women’s healthy-ageing category

Tablet format for structured use

Often chosen as part of broader midlife routines

Not suitable for everyone (hormone-sensitive situations)

Response is highly individual

Not a replacement for clinical care where needed

Follow label directions. If the user has a history of hormone-sensitive conditions, takes medication, or is unsure, professional guidance is recommended before use.

Included because it matches real search demand in women’s longevity routines. Dr Zeeshan Afzal’s view is that it should be used with extra care and clear rationale, not as a generic daily supplement.

Selected as a foundational longevity supplement because B-vitamins support energy metabolism, nervous system function, and methylation pathways. Dr Zeeshan Afzal’s testing prioritised “active” forms, capsule convenience, and suitability as a daily base layer.

A comprehensive B-complex formula in vegetarian capsules, designed for adults who want broad B-vitamin coverage as part of a consistent wellbeing and longevity routine.

Users commonly review B-complex products based on energy steadiness, routine ease, and whether the formula feels “clean” and tolerable. Many consider this category a practical foundation rather than a “specialist” add-on.

£12.07

Life Extension Bio-Active Complete B-Complex (60 Vcaps)

Strong “foundation” supplement category for many adults

Suitable for structured daily routines

Pairs well with targeted add-ons like TMG (if relevant)

Some people are sensitive to B-vitamins (timing matters)

Not necessary if diet already covers needs consistently

Often taken earlier in the day with food. If the user experiences vivid dreams or stimulation, taking it in the morning can help. Follow label directions.

This is one of the most sensible “base layer” options in a longevity plan, particularly for busy adults. Dr Zeeshan Afzal prefers foundational products like this before adding more niche supplements.

Selected for metabolic and nerve-health relevance. Benfotiamine is a well-known thiamine derivative often used in advanced wellness routines. Dr Zeeshan Afzal’s testing prioritised a focused formula, capsule practicality, and suitability for consistent, longer-term use.

A thiamine-support formula combining benfotiamine with thiamine, positioned for adults who want targeted B1-related support as part of metabolic wellbeing and healthy ageing planning.

Users reviewing benfotiamine commonly focus on steady, gradual support rather than immediate effects. Many buyers choose it as a deliberate add-on to a broader metabolic and nutrient routine.

£17.14

Life Extension Benfotiamine with Thiamine 100 mg (120 Vcaps)

Targeted B1 support category

Large capsule count for long-term routines

Good fit for metabolic-focused stacks

Not essential for everyone

Best suited to people with clear rationale for use

Commonly taken daily with food, following label directions. Avoid unnecessary “stacking” of multiple high-dose B products unless there is a clear reason.

This is a strong pick for readers who want a more advanced metabolic-support tool. Dr Zeeshan Afzal’s view is that it works best when foundational nutrition is already in place.

Selected as a neurotransmitter-support category product often used by adults exploring mood, motivation, and focus support as part of a structured wellbeing plan. Dr Zeeshan Afzal’s testing prioritised straightforward dosing and a clean capsule format.

A 500 mg D-L-Phenylalanine supplement in vegetarian capsules. Phenylalanine is an amino acid, and this product is generally positioned for neurological and mood-support routines.

Users often review amino acid supplements based on subtle changes in focus or mood steadiness over time. Feedback typically stresses that results vary and that best use is goal-led and consistent.

£16.25

Life Extension D-L-Phenylalanine 500 mg (100 Vcaps)

Clear amino acid dosing

Vegetarian capsules

Useful for targeted, goal-led routines

Not suitable for everyone; caution is warranted in certain conditions

Not a foundational longevity supplement

Follow label directions. If the user is taking medication, has a history of mood disorders, or has any concerns, professional guidance is recommended before use. Avoid combining with multiple stimulant-like supplements at once.

Best for readers who know why they’re using it and will evaluate it responsibly. Dr Zeeshan Afzal views this as an optional “targeted tool,” not a universal recommendation.

Selected as one of the most practical antioxidant-support tools in longevity routines. NAC is commonly used as a precursor-support nutrient for glutathione pathways. Dr Zeeshan Afzal’s testing prioritised sensible dosing, capsule format, and broad routine compatibility.

A 600 mg NAC supplement in capsule form, typically used by adults who want support for antioxidant systems and overall cellular resilience as part of healthy ageing planning.

Users often report that NAC is easy to integrate and is best assessed over time rather than immediately. Reviews tend to emphasise overall wellbeing support and routine fit, with variable individual response.

£13.67

Life Extension N-Acetyl-L-Cysteine (NAC) 600 mg (60 Capsules)

Widely used in antioxidant-support routines

Clear 600 mg dosing

Easy to stack with other foundational supplements

Some users experience mild digestive sensitivity

Not necessary for everyone if diet and lifestyle already support antioxidant needs

Typically taken daily with water, often with food for comfort. Follow label directions. If the user takes medication or has chronic conditions, professional advice may be appropriate.

NAC remains one of the most sensible “support” supplements for many longevity routines because it’s targeted, well-known, and easy to integrate. Dr Zeeshan Afzal recommends keeping the rest of the stack simple when using NAC.

Selected as a strong foundational longevity supplement because vitamin D and vitamin K are often discussed together in long-term health planning. Dr Zeeshan Afzal’s review prioritised practical daily use, broad relevance, and a format that many adults can maintain consistently.

A combined vitamin D and K supplement with sea iodine, designed for adults who want a structured approach to foundational micronutrients that are commonly referenced in bone, cardiovascular, and general wellbeing strategies.

Users often review D+K products based on long-term routine compatibility rather than immediate effects. Many appreciate combination formulas that reduce the need for multiple separate supplements.

£19.85

Life Extension Vitamins D & K with Sea Iodine (60 Capsules)

Practical combination approach

Strong “foundation” category relevance

Convenient daily capsule format

Not suitable for everyone (e.g., certain medications such as anticoagulants require caution with vitamin K)

Iodine content may not suit all users

Usually taken with food. Follow label directions. If the user takes anticoagulant medication or has thyroid concerns, professional advice is recommended before taking products containing vitamin K or iodine.

This is a strong “daily base layer” option for many adults, particularly in the UK where vitamin D is frequently discussed. Dr Zeeshan Afzal’s preference is to get foundations right before adding niche longevity extras.

Selected as a men’s healthy-ageing botanical formula with clear prostate and urinary comfort positioning. Dr Zeeshan Afzal’s review prioritised ingredient synergy (botanical blend approach), softgel convenience, and suitability for consistent, long-term routines.

A softgel botanical complex combining saw palmetto, nettle root, and beta-sitosterol—ingredients commonly used in prostate-support formulas. Designed for men who want a structured supplement option as part of longevity planning.

Users typically assess botanical prostate formulas over weeks rather than days. Reviews often focus on perceived urinary comfort support and whether the product feels tolerable for daily use.

£23.49

Life Extension PalmettoGuard (60 Softgels)

Botanical blend designed for prostate-focused routines

Softgel format often easy to take

Good fit for consistent, longer-term evaluation

Not relevant for users without prostate goals

Botanical response varies from person to person

Follow label directions, typically with food. Avoid stacking multiple prostate formulas at the same time unless there is a clear reason to do so.

A solid choice for men who prefer botanicals and want an all-in-one approach. Dr Zeeshan Afzal recommends evaluating it with patience and consistency rather than frequent switching between products.

Selected for methylation-focused longevity planning and because folate/B12 are commonly discussed in energy, neurological, and homocysteine-related routines. Dr Zeeshan Afzal’s review favours targeted, purposeful supplementation rather than unnecessary high-dose stacking.

A targeted folate and vitamin B12 capsule formula designed for adults who want a focused approach rather than a full B-complex. Often used in structured routines where folate/B12 status is a specific consideration.

Users typically review folate/B12 products based on energy steadiness, routine fit, and tolerability. Many people prefer targeted formulas when they are already using other B vitamins elsewhere.

£10.23

Life Extension BioActive Folate & Vitamin B12 (90 Vcaps)

Focused methylation-support category

Large capsule count for long-term routines

Useful when a targeted approach is preferred over full B-complex

Not necessary for everyone

Can be redundant if already using a strong B-complex daily

Typically taken daily with food, following label directions. If the user is already taking multiple B vitamin products, review the total stack to avoid unnecessary overlap.

This is a smart pick for people who want a targeted “folate + B12” solution without adding more ingredients. Dr Zeeshan Afzal views it as most useful when there is a specific reason for focused support.

Selected as the most flexible methylation-support option for users who dislike capsules or want adjustable dosing. Dr Zeeshan Afzal includes it because powder formats can improve adherence for some people and allow more precise routine tailoring.

A powdered TMG (trimethylglycine) option designed for adults who prefer powders or want to fine-tune intake. Often mixed into water or a suitable drink as part of a structured longevity routine.

Powder users often review based on mixability, taste neutrality, and convenience. Many prefer powder formats because they can adjust intake more easily than with fixed-dose capsules.

£11.94

Life Extension TMG Powder (50 g)

Flexible dosing (useful for routine tailoring)

No capsules (good for people who dislike pills)

Typically easy to integrate into daily drinks

Powders can be less convenient for travel

Requires measuring (less “grab-and-go”)

Mix as directed on the label. Maintain consistent timing each day for easier evaluation. If used alongside other methylation-support nutrients, avoid unnecessary overlap.

This is ideal for readers who want control and flexibility. Dr Zeeshan Afzal considers powder formats underrated for long-term adherence—especially for people building an intentional routine.