5-MTHF DFE with B12 provides methylation support and healthier blood formation, thanks to the star ingredients, and Kirkman Labs' hypoallergenic, high-purity standards ensure you get a trusted, clean supplement.

Available Sizes & Variants:

200 capsules - standard bottle for easy daily use.

Benefits & Features:

• Supports methylation and DNA synthesis for healthy cells.
• 5-MTHF helps lower homocysteine levels, which supports cardiovascular health and red blood cell production, helping your body make critical DNA and RNA when you need it most.
• Vitamin B12 supports nerve function and helps maintain healthy red blood cells.
• Hypoallergenic formulation offers reassurance for those with sensitivities and dietary restrictions.
• Intended for daily use, it fits neatly into a wellness routine alongside prenatal vitamins or other vitamin b12 supplements for comprehensive support.

From Kirkman Labs, a brand known for hypoallergenic, pure supplements, this 5-MTHF with B12 blends a highly bioavailable folate form with essential B12 to support methylation and nervous system health. The 5-MTHF aids DNA synthesis and helps manage homocysteine, while B12 supports nerve function and red blood cell formation. The formula is hypoallergenic and free from common allergens, reflecting Kirkman’s commitment to clean, high-quality standards that customers can trust. Some customers compare the energy support to a b12 shot, but this is a convenient daily capsule rather than a clinic treatment.

(other) Microcrystalline Cellulose, Vegetarian Capsule (hypromellose and water)

• GTIN: 812325028603
• Manufacturer: Kirkman Laboratories
• Categories: KirkmanNew ArrivalsPopular Supplement BrandsVitamin B12 (Cobalamin) Supplements & Tablets
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one capsule daily or follow your physician's instructions. Add 2 scoops (25g) to a shaker with 350ml of water and shake. It is also great in smoothies!

Please consult the product packaging for accurate instructions on how to use the product.

The Active Ingredient Is: 5-Methyltetrahydrofolate (5-MTHF)

5-Methyltetrahydrofolate, or 5-MTHF, is a readily absorbed form of folate that supports essential cellular processes. This formulation also includes Vitamin B12 to support methylation processes, with 5-MTHF providing the main folate action.

This form is used to participate in one-carbon metabolism and related enzymatic reactions that are important for DNA synthesis and overall cellular function.

What Does 5-MTHF Do?

5-MTHF takes part in methylation and DNA synthesis, playing a part in the conversion of homocysteine to methionine and supporting red blood cell production as part of normal physiological function.

EFSA and NHS guidance recognise the role of folate in these processes, and adding Vitamin B12 supports the broader methylation system within normal cellular activity.

This supplement is not intended to diagnose, treat, cure, or prevent any disease.

Why Kirkman Labs 5-MTHF DFE with B12 is Welzo Selected

Welzo prioritises partnerships with brands that demonstrate pure, hypoallergenic formulations and a clear commitment to quality. Kirkman Labs aligns with this through their emphasis on hypoallergenic, pure ingredients, which mirrors our focus on safe, clean supplements for diverse needs. This brand is known for its reputational standing within the industry as a dedicated label in methylation-support products, and we acknowledge their longstanding presence as part of our evaluation. For our team, the decision to partner with Kirkman Labs rests on their consistent product philosophy and the trust it builds with customers who seek careful formulation.

Our selection process recognises their product focus on 5-MTHF and B12 as a combination that supports methylation and blood cell development in line with the product’s aims. This collaboration is supported by our expert team of doctors, nurses, and nutritionists and our rigorous testing protocols, ensuring quality and safety from sourcing to packaging. The match also reflects Kirkman Labs’ alignment with Welzo’s standards for trusted, well-managed glycerin-free, allergen-conscious formulations.