Endothelial Defense™ Pomegranate Plus, 60 softgels - Life Extension (formerly Endothelial Defense with GliSODin)

Pomegranate, POMELLA® Pomegranate, Superoxide Dismutase/Gliadin Complex

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Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 14 days in the same original and unopened packaging. Subject to T&C's.

Welzo is a UK-based health platform. Orders ship from the UK.

The recommended daily intake is two capsules before breakfast or as directed by a doctor. Take one capsule daily\, or as recommended by a healthcare practitioner. This product is best utilised when taken with fat-containing\, low fibre meals.

Please consult the product packaging for accurate instructions on how to use the product.

Serving Size 2 softgel
Amount Per Serving
Calories	20
Total Fat	1.5 g
Total Carbohydrate	1 g
Protein	<1 g
Cardiose® flavonoid glycoside [from immature sweet orange (peel)] [std. to 90% rutinoside]	500 mg
POMELLA® pomegranate extract (fruit) [std. to 30% punicalagins]	400 mg
Proprietary pomegranate blend (flower extract and seed oil) [std. to 22% punicic acid]	137.5 mg
Pomegranate 5:1 extract (fruit)	100 mg
Extramel® melon pulp concentrate (fruit) [providing 500 IU of SOD enzyme activity]	36 mg
Other ingredients: extra virgin olive oil, gelatin, glycerin, sunflower lecithin, purified water, beeswax, carob color, dextrin.

1. The Endothelial Defense™ Pomegranate Plus supplement from Life Extension contains a potent blend of pomegranate extract, GliSODin, and other key nutrients that support healthy endothelial function.
2. The pomegranate extract in this supplement is rich in antioxidants, which help protect the endothelial cells from damage caused by free radicals, promoting overall cardiovascular health.

The Active Ingredient Is: Hesperidin (Cardiose flavonoid glycoside)

Hesperidin is a bioactive flavonoid glycoside, commonly sourced from citrus peels, that contributes to vascular health through antioxidant pathways and supports normal endothelial function. This form is provided as Cardiose flavonoid glycoside, standardised to a high rutinose content for consistency.

This formula also includes other pomegranate polyphenols and SOD-related components, which collectively support the nutrient's role in vascular health and antioxidant activity.

What Does Hesperidin Do?

Hesperidin is involved in endothelium-dependent vasodilation, contributing to normal blood flow and reduced vascular inflammation as observed in clinical contexts. Research from NHS/EU-aligned guidance notes its role in supporting healthy vascular function when consumed as part of a balanced diet.

Dr. Rizza of the University of Naples found that hesperidin can improve endothelium-dependent vasodilation at the doses represented in this product, aligning with EFSA-style claims about endothelial support.

Compliance disclaimer: This product is not intended to diagnose, treat, cure, or prevent any disease.

Life Extension is our go-to partner for Endothelial Defense Pomegranate Plus because this brand reliably shows a long-running commitment to quality and cardiovascular-focused optimisation. When you compare it with others, Life Extension stands out for its solid reputation in delivering evidence-informed formulations that pair pomegranate polyphenols, hesperidin and SOD with clear quality standards, including its LE Certified status and non-GMO, gluten-free positioning.

The brand’s focus to product integrity, and its emphasis on clinically relevant ingredient blends, lines up with Welzo’s rigour. This is complemented by open formulation choices that reflect a science-led philosophy aimed at supporting endothelial function and vascular health, as described in the fund of research around its core ingredients. Our selection process included looking at how Life Extension maintains manufacturing standards and how these standards support reliability, safety and consistency, backed by our team of medical experts and our criteria for ingredient quality how we verify ingredient quality.

This brand’s know-how, combined with a product built for endothelial support, made Life Extension the clear pick for Welzo.