Endothelial Defence Pomegranate Plus is a heart and blood vessel support supplement that helps maintain healthy endothelium function, powered by pomegranate polyphenols and hesperidin, and backed by Life Extension quality standards. It's simple to take, quick and easy to fit into a busy morning routine, while you focus on daily vitality and supporting healthy blood flow.

Available Sizes & Variants:

60 softgels - convenient daily pack.

Benefits & Features:

• Supports healthy endothelium function for smoother blood flow.
• Hesperidin from Cardiose helps improve endothelium-dependent vasodilation.
• Pomegranate extract brings punicalagins to support vascular flexibility.
• Extramel melon concentrate contributes SOD activity, supporting antioxidant status and potentially reducing oxidative stress that can affect blood vessel health over time, backing daily resilience.
• Non-GMO and gluten free formula helps you feel confident in everyday use.

Endothelial Defence Pomegranate Plus blends a robust polyphenol line to support vascular health. Cardiose hesperidin, POMella pomegranate extract (30% punicalagins) and Extramel SOD work together to support endothelial function and antioxidant status. The formula is non-GMO and gluten free, carrying LE Certified quality standards for everyday confidence. Research on pomegranate polyphenols and hesperidin suggests these ingredients can improve endothelial function and vascular flexibility.

Pomegranate, POMELLA® Pomegranate, Superoxide Dismutase/Gliadin Complex

• GTIN: 737870249764
• Manufacturer: Life Extension
• Categories: CHECKOUT UPSELLNew Arrivals
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

The recommended daily intake is two capsules before breakfast or as directed by a doctor. Take one capsule daily\, or as recommended by a healthcare practitioner. This product is best utilised when taken with fat-containing\, low fibre meals.

Please consult the product packaging for accurate instructions on how to use the product.

The Active Ingredient Is: Hesperidin (Cardiose flavonoid glycoside)

Hesperidin is a bioactive flavonoid glycoside, commonly sourced from citrus peels, that contributes to vascular health through antioxidant pathways and supports normal endothelial function. This form is provided as Cardiose flavonoid glycoside, standardised to a high rutinose content for consistency.

This formula also includes other pomegranate polyphenols and SOD-related components, which collectively support the nutrient's role in vascular health and antioxidant activity.

What Does Hesperidin Do?

Hesperidin is involved in endothelium-dependent vasodilation, contributing to normal blood flow and reduced vascular inflammation as observed in clinical contexts. Research from NHS/EU-aligned guidance notes its role in supporting healthy vascular function when consumed as part of a balanced diet.

Dr. Rizza of the University of Naples found that hesperidin can improve endothelium-dependent vasodilation at the doses represented in this product, aligning with EFSA-style claims about endothelial support.

Life Extension is our go-to partner for Endothelial Defense Pomegranate Plus because this brand reliably shows a long-running commitment to quality and cardiovascular-focused optimisation. When you compare it with others, Life Extension stands out for its solid reputation in delivering evidence-informed formulations that pair pomegranate polyphenols, hesperidin and SOD with clear quality standards, including its LE Certified status and non-GMO, gluten-free positioning.

The brand’s focus to product integrity, and its emphasis on clinically relevant ingredient blends, lines up with Welzo’s rigour. This is complemented by open formulation choices that reflect a science-led philosophy aimed at supporting endothelial function and vascular health, as described in the fund of research around its core ingredients. Our selection process included looking at how Life Extension maintains manufacturing standards and how these standards support reliability, safety and consistency, backed by our team of medical experts and our criteria for ingredient quality how we verify ingredient quality.

This brand’s know-how, combined with a product built for endothelial support, made Life Extension the clear pick for Welzo.