Life Extension Optimized Folate supplies the active 5 MTHF form to support healthy homocysteine levels, and promote cardiovascular wellness and sharper cognitive function for everyday vitality. Using the metabolically active folate, it supports heart and brain health directly, in a vegetarian gluten free non GMO formula. Quality you can trust.

Available Sizes & Variants:

100 vegetarian tabs - convenient monthly supply.

Benefits & Features:

• Supports healthy homocysteine levels.
• The active folate form delivers immediate bioactivity.
• Supports cognitive function and neural health as you age, making it a sensible addition to prenatal vitamins.
• For those with MTHFR variations or elevated homocysteine, L methylfolate provides direct activity without needing extra activation steps, helping you feel steadier and more focused throughout the day.
• This vegetarian, gluten free and non GMO formulation fits well with prenatal vitamins and vitamin d supplement routines.

Life Extension has a long standing commitment to purity and transparency. L methylfolate is the metabolically active form, providing direct bioactivity that supports heart and brain health. The vegetarian, gluten free and non GMO formulation aligns with clean sourcing and careful manufacturing, reinforcing the brand’s dedication to quality you can trust.

Folate as (6S)-5-Methyltetrahydrofolate, calcium salt, Folate as (6S)-5-Methyltetrahydrofolate, calcium salt

• GTIN: 737870193913
• Manufacturer: Life Extension
• Categories: Best SellersLife ExtensionSports Supplements Black Friday Sale
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one vegetarian tablet daily with food, or as recommended by a healthcare practitioner. Store in a cool, dry place, away from sunlight and out of reach of children. Do not exceed the recommended dose. Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs.

Please consult the product packaging for accurate instructions on how to use the product.

*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

The Active Ingredient Is: L-methylfolate (5-MTHF) Calcium Salt

L-methylfolate, the body-ready form of folate, is a B vitamin vital for cells and homocysteine processing.

This calcium salt version delivers the active folate in a vegetarian, gluten-free, non-GMO blend and boosts absorption.

What Does L-methylfolate Do?

L-methylfolate helps convert homocysteine into methionine, supporting normal cardiovascular and nervous system function.

This form bypasses metabolic activation and is easily used by the body, helping to support essential folate roles in brain and heart health. EFSA recognises folate's contributions to normal homocysteine metabolism and neural function.

This supplement is not meant to diagnose, treat, cure, or prevent any illness.

Life Extension is our go-to partner for Optimized Folate because of its solid track record delivering high‑purity, metabolically active folate forms. The brand’s focus on providing L‑methylfolate (5‑MTHF) as the active folate shows a clear commitment to bioavailability and real‑world impact, matching our aim of sourcing products that are readily usable by the body. This product line also emphasises quality through vegetarian, gluten‑free and non‑GMO formulations, reflecting Life Extension’s longstanding dedication to purity and transparency.

Product quality is reinforced by their use of the biologically active 5‑MTHF form, which supports direct cellular uptake. This aligns with our criteria for robust manufacturing standards and reliable ingredient sourcing, and our evaluation team recognises Life Extension for maintaining rigorous quality expectations. We recommend Life Extension Optimized Folate as a trusted option for vitality support, backed by a brand reputation that resonates with our commitment to science‑led supplementation. For our internal assessment, this brand was evaluated by our expert team of doctors, nurses, and nutritionists and assessed against our supplement quality standards to ensure ongoing compliance and safety.