NOW Foods SAMe is a daily supplement that helps keep mood steady and joints a little more comfy, to be honest. The main active ingredient is SAMe, stabilised as disulfate tosylate to help support neurotransmitter production and joint comfort. This brand has a long running commitment to quality, with GMP manufacturing and open ingredient sourcing.

Benefits & Features:

• Supports mood balance and helps maintain a sense of calm throughout the day
• The key active ingredient SAMe supports neurotransmitter production for a steady mood and comfortable joints
• Vegan capsules ensure a clean, allergen friendly format
• Manufactured under GMP standards with stability testing to ensure potency
• Optimal absorption is greatest when taken on an empty stomach, and many users report noticeable mood or joint benefits within two weeks of consistent use and quality formulation

NOW Foods has championed quality supplements since the 1960s, pairing GMP manufacturing with transparent sourcing. The sam e in this product is supplied by Gnosis by Lesaffre, a partner known for pure, stable SAMe forms. The vegan capsules use careful stability testing to keep potency from shelf to shelf. This heritage matters for reliable daily support for mood and joints, and it's really quite reassuring. If you’re building a broader wellness routine, you might also consider our vitamin d supplement and probiotics.

SAMe (S-Adenosyl-L-Methionine) (from S-Adenosyl-L-Methionine Disulfate Tosylate)

• GTIN: 733739001283
• Manufacturer: NOW Foods
• Size: 120 Capsules
• Categories: Best SellersNOW FoodsOur Biggest Black Friday Sale!Sports Supplements Black Friday Sale
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take 1 capsule 2 to 4 times daily, preferably on an empty stomach. Store in a cool, dry place after opening. For adults only. Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult a physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.

Please consult the product packaging for accurate instructions on how to use the product.

*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

The Active Ingredient Is: S-Adenosyl-L-Methionine (SAMe)

S-Adenosyl-L-Methionine, or SAMe, is a naturally occurring compound that takes part in essential cellular processes like methylation and neurotransmitter production. It helps support normal brain function and contributes to joint comfort through its role in connective tissue metabolism.

This form is stabilised SAMe disulfate tosylate, delivered in a vegan capsule with inert ingredients. The product is designed to keep quality and stability across its shelf life.

What Does S-Adenosyl-L-Methionine (SAMe) Do?

SAMe participates in methylation, a biochemical process that supports normal neurotransmitter synthesis and brain function. It also contributes to joint comfort and liver health through its role in metabolic pathways, aligning with evidence reviewed by health experts.

Dr. Kogan of WebMD notes that SAMe can support mood balance and osteoarthritis-related joint comfort, reflecting findings presented by reputable health information sources.

*This product is not intended to diagnose, treat, cure, or prevent any disease.

NOW Foods is our pick for SAMe because the brand blends a long heritage in the field with a straightforward dedication to quality and openness. NOW Foods has built a reputation for solid quality control, GMP-grade manufacturing, and regular QA audits that uphold strong production standards. The company also runs thorough stability testing to guard SAMe’s potency and reliability across shelf life, ensuring customers get consistent performance. This brand was assessed by Welzo's healthcare experts for compliance with how we verify ingredient quality, reflecting our careful vetting process. NOW Foods sources SAMe from reputable pharma-grade suppliers and keeps transparent labelling and batch verification, reinforcing supply chain trust and product purity. For customers, this means a product backed by strict standards and clear sourcing. The collaboration highlights a product-specific fit for mood and joint health needs, while showing Welzo's commitment to expert curation and safety through our team and quality partners.