13 Best Pregnenolone Supplements of 2024

Pregnenolone, a potent neurosteroid that is directly made from cholesterol in the body's brain and adrenal glands, is a precursor to several key hormones, such as progesterone, cortisol, and DHEA. Its deep biological importance has drawn a lot of attention from medical science.

Even though the human body makes it naturally, stress or ageing might occasionally cause its levels to decline. Pregnenolone pills have the benefit of being a useful means of maintaining optimal hormonal balance.

These supplements, which are well-known for their numerous potential health advantages—such as enhancing cognitive function, boosting overall physical vitality, and reducing depressive and anxious symptoms—have grown to be an important resource for individuals of all ages all over the world.

Additionally, the pregnenolone market was valued at USD 0.15 billion in 2022 and is projected to expand at a compound annual growth rate (CAGR) of 7.0% between 2024 and 2030, reaching USD 0.25 billion, according to Future Edge Digital Services. 

As experts continue to investigate the role of this powerful substance in our bodies and how one might fully utilise its potential through supplemental intake, the following section attempts to make it easier to choose from the many options available by offering the best products currently on the market worldwide. 

What is Pregnenolone?

The human body uses pregnenolone, often known as a "master" or precursor hormone, as the beginning point for the synthesis of several essential hormones. Other important hormones including progesterone, cortisol, and DHEA are derived from this basic building block. This specific structure is directly made from cholesterol, mostly in the brain and adrenal glands.

Because pregnenolone can have a good effect on both physical and mental health, understanding it basically helps one understand the molecular system that controls optimal hormonal health.

One of its primary benefits is its capacity to increase brain health; it seems to enhance memory performance while reducing susceptibility to age-related cognitive impairments. Another important advantage is stress management: Acute stress typically causes a spike in pregnenolone levels, which protects your body against the long-term damage that high cortisol levels might cause.

Furthermore, taking pregnenolone supplements may be beneficial when natural reserves begin to diminish due to aging or chronic illnesses, as maintaining balanced hormone levels is still directly linked to overall health.

Our Top Picks

Best overall: Longevity Elite from Quicksilver Scientific

Also Great: Life Elite Cognitex Extension Pregnenolone

Best Long Lasting: Source Naturals Pregnenolone

Best For Stress: Life Extension Pregnenolone

Best Budget: Swanson SuperStrength Pregnenolone

Best Natural: Pregnenolone capsules - Klaire Labs

Best Absorption: Pregnenolone - Biomatrix

Best Mood Enhancer: Pregnenolone Integrative Wellness Supplements

Best Vegan: Pure Encapsulation’s Pregnenolone

Longevity Elite - Quicksilver Scientific

Longevity Elite from Quicksilver Scientific is a powerful blend of adaptogenic herbs and pregnenolone. This 100ml solution offers targeted support for hormonal balance, longevity, and optimal bodily functions via the AMPK pathway and HPA axis. It also promotes sirtuin activation and telomere support, both of which improve overall health.

Why we like it: Longevity Elite's formula is exceptional since it not only encourages hormone production but also prioritises overall health, particularly treating age-related changes by supporting essential biological pathways.

Where to buy and price: Wellzo offers it for £125.84, which makes it easily obtainable online at reasonable prices without compromising quality or effectiveness.

Product review: All of the product's claims are supported by reviews. Users have reported noticeable boosts in energy levels after beginning a regular intake, which positively affects various facets of functioning, from enhanced mental clarity to greater stamina during daily duties.

Life Extension Cognitex Elite Pregnenolone

Life Elite Cognitex Extension Pregnenolone is one expensive dietary supplement designed specifically to enhance cognitive well being and brain clarity. Each bottle of 60 vegetarian tablets contains pregnenolone together with other ingredients that have been scientifically proven to support the best possible brain function.

Apart from its vital role in enhancing memory, mood, and cognitive function, Cognitex Elite also contains phosphatidylserine, which promotes neurotransmitter activation while preserving cell membrane integrity—all of which are necessary for preserving cognitive health. It contains blueberry extract's anthocyanins, which are known to have neuroprotective properties.

Vegetable tablets that are easy to take and made with the highest quality standards ensure total purity and potency, providing a useful way to achieve your wellness goals related to brain function.

Why we like it: By combining a number of nutrients, including potent antioxidants that protect against oxidative stress and give cells an extra line of defence, Cognitex Elite Pregnenolone offers a comprehensive solution for mental health.

Where to buy and price: Welzo sells Life Extension Cognitex Elite Pregnenolone for £47.97 per bottle. 

Product review: The formula's effectiveness has been commended by verified consumers, who have reported measurable improvements in concentration levels over time and an overall increase in energy levels throughout the day, proving the substantial benefits this product is said to offer.

Source Naturals Pregnenolone

Source Naturals Pregnenolone 25mg comes in a potent quantity of 120 tablets each serving. As a precursor to other key hormones, the "mother hormone" is essential for maintaining health and vigour. The product is renowned for its purity and offers both safety and efficacy, and it is manufactured in compliance with stringent GMP regulations.

Why we like it: Many appreciate Source Naturals' commitment to offering premium supplements free of artificial additives that satisfy a range of nutritional needs. Pregnenolone's potential to support mood stability, energy levels, and cognitive function is among its most appealing qualities. This makes it a wonderful choice for those who wish to increase their vitality and hormonal balance while also improving their mental clarity.

Where to buy & Price: Available at Welzo for £18.96

Product Reviews: Customers have frequently praised this product for consistently delivering the intended results, which are typically associated with increased energy, improved emotions, or enhanced cognitive function.

Life Extension Pregnenolone

Life Extension A fantastic nutritional supplement, pregnenolone promotes the body's natural hormone balance and general well-being. With 50 mg per pill, pregnenolone, a precursor hormone that seamlessly synchronises the manufacture of necessary ones like oestrogen, testosterone, and cortisol, surges. It is advised for people who wish to maintain ideal hormonal balance while promoting emotional stability and mental clarity.

Why we like it: Life Extension as a Supplement By enhancing mental clarity and focus and possibly memory, pregnenolone seems to lower stress and improve overall well being. This comprehensive medication, which comes in a bottle containing 100 capsules, is a practical, long-lasting treatment that will continuously support your hormonal balance.

Where to buy and price: Available conveniently online via Welzo priced sensibly at £22.13

Product Reviews: After adopting regular health habits, consumers who successfully balance lifestyle choices across a diverse user base worldwide report noticeable increases in their energy levels and cognitive function.

Swanson SuperStrength Pregnenolone

The goal of the expertly formulated Swanson SuperStrength Pregnenolone 50mg supplement is to enhance overall wellbeing, maintain hormonal balance, and support mental health. A potent dosage of premium pregnenolone is present in each capsule, enabling the most benefits from every use.

Why we like it: For those who wish to maintain a stress-free mood while also enhancing their memory, cognitive function, and mental clarity, Swanson SuperStrength Pregnenolone is highly recommended due to its exceptional role as a precursor to essential hormones such as oestrogen, progesterone, and DHEA.

Where to buy and price: Bottles of 60 tablets from Welzo cost £8.11 apiece.

Product review: Customers frequently compliment the product on its capacity to reduce stress and promote brain health, suggesting that regular use results in a noticeable improvement.

Pregnenolone capsules - Klaire Labs

Klaire Labs enters the health supplement industry with their Pregnenolone pills. Each capsule includes 25 mg of physiologically active pregnenolone made from natural diosgenin sterols, making it a beneficial addition to any wellness regimen. These capsules are distinct due to their unique micronization technique, which guarantees simple and efficient absorption by reducing particles on a molecular level for direct body digestion.

Why we like it: When searching for ways to support adrenal gland function or boost mental clarity in the face of our hectic lives, Klaire Labs' Pregnenolone is a compelling option to consider. It is made entirely of natural substances and enhanced by innovative formulation techniques intended to maximise the body's use.

Where to buy and price: At £31.67, this box of 100 vegetarian-friendly Pregnenolone pills is presently offered on the Welzo online retail portal.

Product Reviews: Consumers have raved about this product, saying that after using it consistently for a few weeks, they experienced measurable increases in cognitive function and a decrease in stress.

Pregnenolone - Biomatrix

A new pregnenolone supplement called BioMatrix is derived from an extract of wild yams (Dioscorea villosa). Maximum absorption and effectiveness are ensured by its chemical structure, which is very comparable to the molecule found naturally in the body.The liquid Pregnenolone Drops are intended to help your immunity, mood, and memory.

According to ongoing research, this medication is effective in treating autoimmune diseases, enhancing sleep, and aiding in the healing process following nerve injury. An alcohol basis that further enhances absorption, a micronised form that gives up to three times stronger neuropathological reactions than standard forms, and the sustainably derived steroidal backbone of wild yams are the sources of BioMatrix's components.

Why we like it: Because of its well balanced composition, BioMatrix pregnenolone is easily absorbed and has a formulation that replicates what the body naturally produces. Because it is extracted utilising sustainable ways, the benefits offered by the master hormone itself are given more legitimacy and quality.

Where to buy and price: Welzo sells Pregnenolone from BioMatrix, which is reasonably priced at £46.15. 

Product reviews: Customers report that their overall health has improved, especially their energy levels and cognitive abilities, and they attribute these improvements to regular use of their drops.

Pregnenolone - Integrative Wellness Supplements

Pregnenolone Integrative Wellness Supplements are an amazing way to enhance neurofunctional abilities and hormonal balance. Known as the "mother of all hormones," pregnenolone is necessary for the synthesis of important bodily hormones such as cortisol, aldosterone, oestrogen, testosterone, progesterone, and DHEA.

Why we like it: These supplements are widely recognised for their numerous benefits, which include enhancing memory and cognitive health as well as promoting mood regulation and overall well-being. Their robust stress response system, which effectively boosts the body's tolerance to the challenges of the modern environment, is one of their key traits.

Where to buy and cost: You can secure your path to improved mental clarity and balanced hormonal wellbeing for a very reasonable £13.87.

Product review: Many clients stated that their cognitive abilities had significantly improved, particularly in the areas of memory retention and stress management. Users also reported feeling more energetic and having more happiness infiltrate their daily routines after three months of frequent use.

Pure Encapsulations Pregnenolone

Pure Encapsulation’s Pregnenolone is one special hormone precursor that has been created to assist both men and women in achieving hormonal balance. Beyond this, it aims to enhance memory health and foster a comprehensive sense of well-being.

The product's gluten-free features and adherence to non-GMO regulations are ensured by the use of premium vegan ingredients throughout production.Customers can modify their intake to meet their specific demands thanks to its adjustable dosage options, which include 10 mg or 30 mg capsules. This is an additional feature.

Why we like it: Because it simultaneously supports both hormonal balance and cognitive health, this tablet has garnered a lot of interest. The product's efficacy is supported by its clean-label concept, which eliminates common allergens, artificial substances, and unnecessary ingredients from formulation.

Where To Buy & Price: For those interested obtaining Pure Encapsulations Pregnenolone supplements must note that currently Amazon remains viable purchasing platform pricing units £14.90.

Product Reviews: Notable documented improvements Improved mental clarity due to hormone balance several assessments attesting to overall wellbeing

Best Naturals Pregnenolone

Best Naturals Pregnenolone's combination is designed to preserve purity and quality. Each bottle contains 120 pills, each of which contains 30 milligrammes of pregnenolone. It stands out since it is made at a US facility that is FDA-registered and guarantees to adhere to stringent GMP guidelines.

Why we like it: Its gluten-free certifications and non-GMO status satisfy a variety of dietary needs, demonstrating the brand's inclusive approach to wellness product creation. For consumers who are concerned about their health, sodium-free supplements are the ideal choice because they don't contain artificial colouring, flavouring, or sweeteners, and they don't cause allergies to things like milk, maize, soy, eggs, lactose, wheat, yeast, or seafood.

Where to Buy & Price: Best Naturals Pregnenolone is available on Amazon for just £7.92 a bottle, which is a great deal that definitely makes it more alluring.

Customer Reviews: Customers appreciate the company's commitment to using natural ingredients devoid of harmful preservatives and give it high scores for measurable improvements in cognitive function and stress management with regular use.

Pregnenolone, Premier

Premier is a well-known supplement that contains plant-based ingredients. Apart from being an essential precursor to several vital hormones, it also keeps consumers' emotions in balance and makes them feel good about themselves.

Premier pregnenolone stands out as inclusive wellness products due to their strict adherence to vegan and vegetarian dietary rules, non-GMO status, and lack of gluten and soy.

Why we like it: Premier's wide range of health advantages, especially its potential mood-boosting qualities and vital function in maintaining hormonal balance, frequently attract customers searching for natural solutions to preserve optimal wellbeing. Its commitment to clean formulation adds another level of confidence in the product's dependability.

Product Reviews: The vast majority of favourable reviews for this drug indicate that it is effective in enhancing hormone management in general, which elevates mood and cognitive function. Customers typically report feeling more emotionally and physically balanced after incorporating it into their daily routine, and some even assert that drinking it enhances their cognitive function.

Nutricost Pregnenolone

Nutricost Pregnenolone distinguishes itself with a carefully thought-out formula that provides optimal effectiveness and user-friendliness. Each container has 120 servings in an easy-to-swallow capsule that contains 10 milligrammes of pregnenolone. Their appeal is further enhanced by the fact that their plant-based "veggie" capsules are gluten-free and non-GMO, making them suitable for anyone adhering to certain dietary restrictions.

Why we like it: The product's user-friendliness is largely due to its single-capsule serving size, which is regularly supplied with precisely calculated dosage quantities. In addition, quality is guaranteed and users may feel secure knowing that the product is made in compliance with GMP compliance criteria.

Where To Buy & Price: Nutricost Pregnenolone is available on Amazon at an affordable price of £9.11

Product Reviews: Customer reviews usually emphasise positive encounters. Consumers think serving sizes are advantageous and yield observable results. Because it guarantees inclusivity by leaving out specific components, commenters also commend the formulation for being accessible to a range of speciality diets.

Designs for Health Pregnenolone CRT

Designs Associated with Health A supplement that supports a healthy hormone balance is pregnenolone CRT, a precursor of many hormones such as DHEA, progesterone, oestrogens, testosterone, cortisol, and aldosterone. Its most noticeable feature remains its Controlled Release technology, which eliminates any surges or spikes associated with alternative delivery systems.

In addition to regulating hormone levels, this drug aids with memory and cognitive function. The vegetarian-friendly, gluten- and dairy-free formulation of this product adds even more value.

Why we like it: Why Designs for Health is different Pregnenolone CRT is special because of its controlled release mechanism, which distributes the drug continuously over a period of 10 to 12 hours to guarantee regular absorption and avoid sudden spikes that could throw off the body's balance.

When paired with other advantages like potential cognitive support and a substantial contribution to actively balancing a range of hormonally active substances, a holistic wellness booster is worthy of consideration.

Where To Buy & Price: Available at £9.11 easily found at Amazon.

Product Reviews: Most people who use these supplements report very positive results, such as increased mental clarity and a slow but noticeable decrease in mood swings and unanticipated hormonal changes.

Summary

Depending on individual needs, choosing the right supplement—like pregnenolone—is essential to reaching health goals. Before starting a supplement program, you should always see a healthcare professional to ensure safety and efficacy. Because pregnenolone supplements can assist general wellness by maintaining hormonal balance and enhancing cognitive functions, their many benefits have been widely recognised.

Frequently Asked Questions

What is the best dosage for pregnenolone supplements?

The recommended daily dosage for pregnenolone supplements typically ranges from 5 to 50 mg, depending on individual needs and circumstances. It is advised that those starting new supplementation start with a lower dosage under the supervision of a healthcare professional.

Are there any side effects of taking pregnenolone?

Despite its benefits, long-term usage of high doses of pregnenolone may produce headaches or irritation in certain individuals. This highlights how crucial it is to adhere to the dose recommendations made by your doctor.

How do I know if I need pregnenolone supplements?

The first step in figuring out whether you need to incorporate these supplements into your regular health routine is identifying your symptoms. low hormone levels, resulting in mood swings, chronic fatigue, and difficulty thinking clearly It's advisable to discuss the use of a pregnenolone supplement with your doctor if you frequently deal with such issues.

Can I take pregnenolone supplements with other medications?

Numerous drugs commonly interact with pregnenolone. To avoid adverse reactions from combining substances, it is crucial to discuss any medications you are currently taking with your healthcare provider prior to starting a supplementation program.