Doctor's Best SAM-e is a SAM-e supplement that helps mood, joint comfort and liver health, thanks to a highly bioavailable, enteric coated tablet. The key active ingredient is SAM-e, and the formula is made by Doctor's Best with strict quality controls to ensure purity and potency. An enteric coating helps protect the ingredient from stomach acid, helping it reach the gut where it’s best absorbed.

Available Sizes & Variants:

60 tablets SAM-e - convenient one month supply.

Benefits & Features:

• Helps mood balance and daily wellbeing with SAM-e.
• Supports joint comfort and mobility, helping you move more freely throughout the day.
• Enteric coating helps protect SAM-e from stomach acid for better absorption.
• Vegan, gluten-free and non-GMO formula suits many lifestyles with confidence.
• SAM-e stands out as the star ingredient, backed by Soloesse branding and cGMP manufacturing, delivering consistent purity and stability that steady mood, joint comfort and everyday wellbeing.

Doctor's Best has earned a reputation for clean, reliable supplements. This SAM-e formula comes via Italy's Soloesse patented process, using pharmaceutical-grade SAM-e with a high active S form. Enteric coating and temperature-stable blister packs protect potency, while vegan, gluten-free and non-GMO ingredients ensure broad tolerance. The brand tests every step and uses branded materials for authenticity. It’s designed to slide into everyday skincare and makeup routines for a balanced, confident you.

S-Adenosyl Methionine (from SAM-e tosylate disulfate)

• GTIN: 753950002524
• Manufacturer: Doctor's Best
• Categories: Doctor's Best
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one tablet of Doctor's Best SAM-e, 400 mg Double-Strength daily between meals or as directed by a healthcare professional. Do not chew or crush the tablet. Store in a cool, dry place. Consult your doctor before use if you are taking antidepressants, have bipolar disorder, or are pregnant or breastfeeding. May cause gastrointestinal discomfort in a small percentage of individuals.

Please consult the product packaging for accurate instructions on how to use the product.

*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

The Active Ingredient Is: SAM-e (S-Adenosyl-L-Methionine disulfate p-toluensulfonate)

SAM-e is a biologically active compound that (acts->functions) as a methyl donor in (many->numerous) cellular processes. This form uses disulfate p-toluensulfonate to (aid->help) stability and (absorption->uptake) in the (digestive tract->gut).

(Designed->Designed) as enteric-coated tablets, the ingredient is produced to (high purity standards->very clean standards) and is vegan, non-GMO, gluten-free, and dairy-free where applicable.

What Does SAM-e Do?

Dr. Galizia of the University of Milan (noted->observed) that SAM-e supports mood, joint comfort, and liver health, (aligning with->matching) EFSA-consistent perspectives on these roles. It (participates in->involves itself in) pathways (related to->connected to) mood regulation, joint function, and liver cell protection.

In this product, SAM-e is (presented->shown) in a (highly bioavailable->very bioavailable) form to (assist->help) normal physiological processes (associated with->linked to) these areas.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Doctor's Best SAM-e fits Welzo's strict partner screening criteria, favouring brand integrity, production excellence and open quality oversight. This brand stands out in the British market for its clear commitment to pharmaceutical-grade standards and thorough testing throughout production, which we recognise as a cornerstone of our supplier relationship. our panel of doctors, nurses, and nutritionists carefully evaluated Doctor's Best for alignment with our quality assurance process and confirmed their dedication to purity, potency and traceability.

The brand history emphasises manufacturing excellence in Italy using Soloesse®, a patented, pharmaceutical-grade SAM-e, with cGMP-compliant production and comprehensive in-process and finished-product testing. This positions Doctor's Best strongly in the British market as a provider of reliable, well-documented ingredients and stable, enteric-coated formats that support product integrity over time.

Why this brand over competitors is clear: the combination of patented active form, temperature-stable packaging, and branded materials reflects a disciplined approach to quality. This makes Doctor's Best particularly well suited for SAM-e, and supports Welzo’s partnership goals of safety, transparency and consumer confidence.