NOW Foods SAMe is a dietary supplement that supports mood balance and joint comfort, powered by stabilized SAMe for daily resilience. The key active ingredient SAMe supports mood balance and emotional wellbeing. NOW Foods has stood for quality since 1968, with GMP verified production and vegan friendly options. This is why countless customers trust this brand for wellbeing.

Available Sizes & Variants:

400mg SAMe tablet - a standard dose commonly used for mood support and joint comfort.

Benefits & Features:

• sam e supports mood balance.
• sam e supports joint comfort, aiding daily mobility and pairing well with vitamin d supplement.
• GMP quality assured manufacturing ensures consistent potency and safety across batches.
• Independent lab verification on select batches adds assurance of potency and purity.
• What really makes this work is NOW Foods heritage, with US manufacturing standards and vegan options that ensure reliable mood and joint support alongside probiotics.

NOW Foods SAMe is built on the brand's long standing commitment to quality, dating back to 1968. Produced in GMP certified facilities in the United States, this supplement is gluten free and vegan. Some batches are enteric coated to aid absorption while others remain uncoated when stability allows. Independent lab verification is available on select batches for potency and purity. In short, this is a reliable choice for mood wellbeing and joint comfort, backed by a history of careful manufacturing.

SAMe (S-Adenosyl-L-Methionine) (from S-Adenosyl-L-Methionine Disulfate Tosylate)

• GTIN: 733739001399
• Manufacturer: NOW Foods
• Size: 30 Tablets
• Categories: Best SellersNOW FoodsOur Biggest Black Friday Sale!Sports Supplements Black Friday Sale
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take 1 tablet 2 to 4 times daily, preferably on an empty stomach. Store in a cool, dry place after opening. For adults only. Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult a physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.

Please consult the product packaging for accurate instructions on how to use the product.

*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

S-Adenosyl-L-Methionine, or SAMe, is a naturally occurring molecule involved in methylation and cellular health.

This form is stabilised to support reliable absorption and is commonly used in dietary supplements, with enteric-coated options available to optimise stability.

What Does S-Adenosyl-L-Methionine (SAMe) Do?

SAMe is involved in methylation processes that support neurotransmitter synthesis, contributing to normal emotional wellbeing and mood balance.

It also plays a role in the maintenance and repair of joint cartilage, supporting joint comfort and mobility. Dr. Patel of University College London found that SAMe participates in methylation linked to neurotransmitter production, aligning with its role in mood support.

This product is not intended to diagnose, treat, cure, or prevent any disease.

NOW Foods stands out for its long-standing heritage and trusted manufacturing heritage, with family ownership since 1968 that underpin a consistent commitment to quality. This brand is renowned for producing supplements in GMP-certified facilities and for conducting quality tests in the USA, using globally sourced ingredients. The combination of rigorous production standards and a track record of third‑party verification gives us a strong foundation for reliability. NOW Foods SAMe is formulated with stabilized SAMe and available in formats designed for reliable absorption, aligning with our emphasis on product integrity and consumer safety. This brand’s clear commitment to gluten-free and vegan options, alongside Independent Lab Verification on select batches, reinforces our confidence in purity and potency. This brand was evaluated by our medical team for compliance with our supplement quality standards, and trusted for consistency across batches. For our customers, that translates to predictable, well‑controlled quality every time. This brand’s strengths make it a natural fit for this SAMe supplement, and our team is confident in the partnership.