SAM-e is a nutritional supplement that backs mood, joint health and liver function, helping you feel more balanced and composed, and able to move through the day. Enteric coated tablets shield the active ingredient, improving stability and delivery. Doctor's Best is recognised for GMP certified facilities and rigorous quality checks, giving you confidence in daily SAM-e.

Available Sizes & Variants:

60 enteric coated tablets - convenient monthly supply for daily SAM-e support.

Benefits & Features:

• Mood balance improves with sam e, quickly.
• Joint comfort and mobility improve, with evidence suggesting SAM-e can be as effective as non steroidal drugs for knee or hip osteoarthritis, while usually having fewer side effects.
• Enteric coated tablets protect SAM-e from stomach acid, helping ensure the active ingredient reaches the small intestine.
• Supports liver function and helps normalise certain enzymes, contributing to overall metabolic balance.
• Made in GMP certified facilities with strict quality checks, Doctor's Best emphasises safety, giving you confidence when taking SAM-e daily, and peace of mind.

Doctor's Best has built a reputation for quality and straightforward sourcing, with sam e delivered in an enteric coated tablet to guard against stomach acid and preserve potency. The star ingredient is sam e, a universal methyl donor that supports multiple body systems, including neurotransmitter production and liver function. This product is manufactured in GMP certified facilities, with rigorous quality checks to ensure consistent potency. It sits neatly in a wellness routine alongside other daily favourites like probiotics. It can slot into a vitamin d supplement routine when recommended by a healthcare professional.

(other) Microcrystalline cellulose, stearic acid, calcium chloride anhydrous, magnesium silicate, magnesium stearate, magnesium hydroxide, flake shellac dewaxed, glycerol, silica, arginine base, sodium alginate, calcium oxide.

• GTIN: 753950002524
• Manufacturer: Doctor's Best
• Categories: CHECKOUT UPSELLDoctor's BestNew Arrivals
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one tablet daily, preferably between meals, or as advised by a healthcare professional. Do not chew or break the tablet. Take 1 capsule daily with food or as directed by your healthcare professional. Capsules may be pulled apart and nutrients taken separately.

Please consult the product packaging for accurate instructions on how to use the product.

1. SAM-e, also known as S-adenosylmethionine, is a naturally occurring compound in the body that has been shown to have numerous health benefits. It is involved in the production of neurotransmitters, hormones, and other important molecules.
2. Doctor's Best SAM-e supplement comes in a 400mg 60 enteric coated tablets form, which ensures maximum absorption and protects the sensitive ingredients from stomach acid, allowing them to reach the small intestine where they can be absorbed efficiently.

The Active Ingredient Is: S-Adenosylmethionine (SAM-e)

S-Adenosylmethionine, or SAM-e, is a common methyl donor involved in lots of cellular reactions and in making certain neurotransmitters. This enteric-coated formulation helps shield SAM-e from stomach acid and helps get it to the small intestine.

What Does S-Adenosylmethionine Do?

SAM-e takes part in methylation processes that support normal brain function and can contribute to mood and joint health in studies. It may also support liver function in appropriate contexts, aligning with evidence on its biochemical role as a methyl donor and facilitator of enzymatic reactions.

*This supplement is not intended to diagnose, treat, cure, or prevent any disease.

Doctor’s Best brings a well-established heritage of quality in the supplement space, recognised for manufacturing in GMP-certified facilities and upholding strict quality controls that prioritise potency and purity. This brand has become a trusted partner in delivering reliable, carefully produced nutrients, which aligns with Welzo’s commitment to safety and transparency. Our medical team our medical team evaluated Doctor’s Best for compliance with stringent manufacturing standards and overall quality philosophy, while our our rigorous testing protocols were used to confirm their dedicated quality framework.

We selected Doctor’s Best over other brands because of their clear emphasis on quality, stability and delivery accuracy, demonstrated by features such as enteric coating that protects SAM-e and supports formulation integrity. This product is a solid fit for a SAM-e supplement, offering a high-quality option from a brand with a proven track record in quality manufacturing. The pairing between Doctor’s Best and Welzo reflects alignment between brand strengths and product requirements, reinforced by our thorough brand evaluation process.