Resveratrol & Trans-Resveratrol Supplements Supplements

Resveratrol is a naturally occurring polyphenol found in red grapes, berries, and peanuts. It functions as a phytoalexin—a protective compound plants produce under stress. The trans-resveratrol isomer is the biologically active and stable form most commonly used in clinical research and high-quality supplements. It has been studied for its potential to support healthy ageing, cardiovascular health, antioxidant protection, and metabolic balance.

Evidence-Based Benefits of Resveratrol

1. Antioxidant and Anti-Inflammatory Support
Resveratrol acts as a potent antioxidant, helping to neutralise free radicals and reduce oxidative stress. It supports cellular protection by modulating inflammation pathways such as NF-κB, which are associated with chronic inflammation and ageing.
Expert insight:
“Resveratrol acts as a cellular shield, reducing oxidative damage that contributes to tissue ageing.” — Cleveland Clinic Health Team

2. Cardiovascular and Circulatory Health
Studies suggest resveratrol can improve endothelial (blood vessel) function, reduce platelet aggregation, and help maintain healthy cholesterol ratios. Some research indicates it may support blood pressure regulation and enhance vascular resilience.
Expert insight:
“Polyphenols like resveratrol can help maintain healthy blood flow and circulation.” — Linus Pauling Institute, Oregon State University

3. Metabolic and Glucose Regulation
Clinical evidence suggests resveratrol may improve insulin sensitivity and glucose control, particularly in individuals with metabolic syndrome or type 2 diabetes. It can also support lipid metabolism and energy utilisation when combined with a balanced diet and regular exercise.

4. Brain, Cognition, and Longevity Potential
Resveratrol has demonstrated neuroprotective potential in laboratory studies. It may help protect brain cells from oxidative stress and support cognitive performance. While animal models indicate possible lifespan benefits, human trials remain inconclusive.
Expert insight:
“Current evidence is encouraging but not conclusive for resveratrol’s effects on human longevity.” — International Journal of Molecular Sciences

What the Research Shows

The scientific consensus is that resveratrol exhibits significant antioxidant and metabolic activity, but human results are mixed and dose-dependent.
Key takeaways:

• Benefits are most pronounced in cardiovascular and glucose-related areas.

• Bioavailability remains limited; formulations with piperine or liposomal delivery offer improved absorption.

• Long-term safety data are positive at moderate doses (up to 1,000 mg/day).

Common side effects include mild digestive upset at higher doses. Due to its influence on platelet aggregation, individuals on anticoagulant medication or preparing for surgery should seek medical advice before use.

How to Choose a High-Quality Resveratrol Supplement

1. Form and Purity
Select Trans-Resveratrol (98% or higher purity), ideally extracted from Japanese Knotweed (Polygonum cuspidatum).

2. Dosage
Typical effective daily doses range from 250 mg to 1,000 mg. Beginners should start at 250–300 mg and adjust as guided by a healthcare professional.

3. Enhanced Absorption
Prefer formulations that include piperine, liposomal delivery, or synergistic compounds such as quercetin or CoQ10 to enhance bioavailability.

4. Manufacturing and Testing
Only purchase from brands that are GMP-certified, third-party tested, and transparent with Certificates of Analysis confirming purity and potency.

Top Resveratrol and Trans-Resveratrol Supplement Options

Safety, Interactions, and Use

Resveratrol is considered safe when used responsibly within recommended doses. Potential side effects include mild nausea or digestive discomfort at high doses. Individuals who are pregnant, breastfeeding, or taking medications such as anticoagulants should consult a healthcare provider before use. Always follow the dosage instructions provided by your supplement manufacturer and store products away from heat and light to preserve potency.

Frequently Asked Questions

What is the difference between resveratrol and trans-resveratrol?
Resveratrol is the general compound name; trans-resveratrol refers to the biologically active isomer with greater stability and absorption potential.

How much resveratrol should I take daily?
Human studies vary between 250 mg and 1,000 mg per day. There is no established official daily requirement. Always start with the lowest effective dose and increase only under supervision.

Does resveratrol really slow ageing?
While laboratory research indicates anti-ageing and longevity effects, clinical trials in humans have not yet confirmed direct lifespan benefits.

Can I take resveratrol with other supplements?
Yes, it is often combined with CoQ10, quercetin, or piperine for enhanced absorption and synergistic antioxidant support. Always ensure ingredient compatibility.

Are there any known interactions?
Resveratrol may interact with blood-thinning medications or affect clotting. Discuss use with your doctor if you are on prescription medication.

Summary

Resveratrol, especially the trans form, is a well-studied plant compound offering antioxidant, cardiovascular, and metabolic benefits. While human data remain mixed, it is one of the most researched polyphenols for healthy ageing. Selecting a pure, clinically dosed, and third-party tested trans-resveratrol supplement ensures optimal quality and efficacy. Supplements are best used as part of a holistic lifestyle that includes balanced nutrition, regular exercise, and stress management.