Nitric Oxide Supplements: Uses, Side Effects and Are they Safe?

Nitric Oxide, a critical yet versatile molecule naturally produced in our bodies, has recently drawn considerable attention for its key role in sustaining overall health. It acts as a powerful vasodilator integral to cell communication and supports varied physiological functions ranging from neural operations to managing blood pressure.

Prominent American physician Dr Andrew Thomas Weil, specializing in integrative medicine, elucidates that nitric oxide is essential in regulating blood flow while ensuring efficient oxygen delivery at the cellular level.

Strong scientific evidence showcasing benefits such as reduced cardiovascular disease risk and improved physical performance, cited by the Journal of Applied Physiology, have led many people to consider Nitric Oxide supplements with enthusiasm for potential wellness enhancement.

However, despite promising indications that such supplementations enhance overall well-being, valid concerns still need to be addressed over their safety profiles or possible side effects owing to the need for long-term comprehensive studies.

The Journal of Medical Toxicology noted a fluctuating trend in dietary supplement exposure over the years. From 2000-2002, there was an elevation of around 46.1%, then dipped by about 8.8% between mid-2002 to late-2005. It surged again, significantly increasing by almost half (49.3%) from the later part year of the early decade till almost the end-year phase second ensuing decade, i.e., set time frame encompassing duration falling between initial portion cycle following the first five years or so on until close out twelve thirty-day spans typically representing a single revolution around the sun within given orbit These patterns indicate an alarming increase in misunderstanding and misuse associated with these products.

What is Nitric Oxide?

Symbolized as 'NO' in chemical terms, Nitric Oxide is an uncomplicated molecule comprising a single nitrogen and oxygen atom. Yet, its role within the human body is far from simple, and its health impacts are wide-ranging.

Notably acting as a facilitator for communication between cells and a powerful vasodilator securing blood flow efficiency, Nitric Oxide earned a reputable distinction when Science Magazine declared it "Molecule Of The Year" in 1992. This honor was due to its extensive benefits and remarkable physiological importance.

The production process begins with precursor amino acid-L-arginine, noted by Louis Ignarro's Nobel Prize-winning research. This research sparked an understanding that when L-arginine breaks down inside our body, NO forms as a by-product fueling various essential functions, including but not limited to muscular contraction-relaxation cycle regulation or controlling inflammatory responses.

Appreciating such an extensive influence on human well-being makes nitrate supplementation consumption considerable yet demands better awareness of the safety considerations accompanying its use.

Benefit Of Nitric Oxide

Nitric Oxide presents a wealth of benefits backed by scientific evidence. It impacts diverse aspects of human health, with benefits often overlapping due to its integrative function within the body:

Improved Blood Circulation: Nitric oxide is a potent vasodilator. The Journal of Molecular and Cellular Cardiology states that it helps expand blood vessels, enabling efficient circulation. This action aids in maintaining healthy blood pressure levels.

Enhanced Physical Performance: Studies have linked NO to improved exercise performance. Increasing the oxygen supply during strenuous activities makes muscles less likely to fatigue, promoting endurance and strength.

Regulated Immune System Functioning: Evidence suggests that nitric oxide plays an important role in immune responses to fight bacterial infections.

Neurotransmission Support: A study indicates that nitric oxide acts like a neurotransmitter supporting brain functions such as memory retrieval and learning processes.

How to Take Nitric Oxide Supplements

Effectively taking nitric oxide supplements depends largely on the individual's health condition, fitness goals and product instructions. 

Most commonly found in either tablet or powder form, consumption usually takes half an hour to one hour before physical exercise, promoting enhanced performance. However, nutrient timing is only one of the factors to consider, as supplementation should ideally be coupled with a diet rich in nitrates - such as fruits, vegetables, beetroot, and spinach for optimal endogenous production results.

Adhere to the manufacturer-suggested dosages and avoid prolonged use without scientific backing to ensure the best results and avoid side effects.

Dosage

Determining the right dosage for Nitric Oxide supplements depends on individual health status and physical goals. Typically, manufacturers suggest doses ranging from 2 to 15 grams per day split into pre-workout and post-meal servings. However, higher dosages do not ensure better benefits and might cause side effects such as stomach discomfort or low blood pressure.

Possible Risks and Side Effects

Despite Nitric Oxide's evident benefits, it is essential to consider potential risks with supplementation. 

Variations in Blood Pressure: Overconsumption of these supplements risk inducing hypotension or low blood pressure.

Digestive Issues: Consumption might trigger stomach upsets or bloating incidents.

Extended Bleeding Duration: Supplements observe a connection with diminished platelet aggregation, potentially elongating bleeding timelines during injury instances. 

Allergic Outcomes: Some products have the potential to provoke unwanted reactions, which can manifest as skin rashes, hives, or impaired breathing.

Available Nitric Oxide Supplements

At Welzo, you can get nitric oxide supplements in different forms; these include:

L-Arginine Plus

Thorne's L-Arginine Plus is a prime supplement that contains the essential amino acid L-Arginine. Its 180 capsules are specially formulated to bolster heart health and muscle metabolism while enhancing athletes' performance and recovery. The product's standout feature is its blend boosting nitric oxide synthesis for improved blood flow and muscle recovery. Additionally, freedom from common allergens such as gluten or soy alongside artificial additives makes it an attractive choice at £66.27, given its high-quality constitution and generous dosage count.

L-Arginine HCL

Lamberts L-Arginine is a premium supplement offering 1000mg of easily absorbable L-Arginine per tablet. This product, made to pharmaceutical standards in the UK, supports healthy blood flow via nitric oxide production. Particularly beneficial during periods of growth or stress when arginine becomes 'conditionally essential,' this supplement costs roughly £19.75 for 90 tablets.

L-Arginine Complete Mixed Berry

Fenix Nutrition's L-Arginine Complete Mixed Berry is a groundbreaking heart health supplement. Its potent blend of L-arginine and L-citrulline assists in maintaining healthy Nitric Oxide levels—all backed by Nobel Prize-winning research. Despite its high customer rating of 5/5 and convenient usage method promoting cardiovascular well-being, consumers must consult with their healthcare provider before initiating use—especially crucial for individuals below adult age. Expect to pay £51.63 for each 300g container.

Takeaway

Nitric oxide, a critical molecule in the human body, enhances physical performance and blood circulation to support immune responses. Supplements have become popular for these potential benefits yet should only be initiated when considering possible side effects such as digestive distress or low blood pressure. Adherence to appropriate dosages, usually between 2 and 15 grams daily, is essential. Consulting a healthcare provider is important before initiating any supplement regimen to ensure safety and efficacy at an individual level.

Frequently Asked Questions

Is it safe to take nitric oxide supplements?

The safety of nitric oxide supplements varies with personal health and dosage adherence. Potential benefits come with side effects like digestive issues or low blood pressure.

Is nitric oxide harmful to humans?

Nitric Oxide is generally safe for humans. Yet excessive supplementation might cause side effects like low blood pressure or stomach distress, making medical guidance essential during usage.

Is nitric oxide good or bad for your heart?

Nitric oxide is beneficial for heart health. It enhances blood circulation and aids in maintaining optimal pressure levels, reducing the risk of cardiovascular diseases.

How long do nitric oxide supplements take to work?

Nitric Oxide supplements usually work within an hour of being taken, but some other benefits might take a few weeks to notice.