Nicotinamide
Vitamin B group member nicotinamide is a water-soluble vitamin. Niacinamide and nicotinic acid amide are other names for nicotinamide. Niacin, also known as vitamin B3, is an amide of nicotinic acid.Supplemental niacinamide is typically well tolerated. Mild gastrointestinal upset is the most frequent side effect, which can be prevented by taking the supplement with food. Some people may experience skin flushing from nicotinamide. As long as the supplement is used regularly, this side effect should subside. Rarely, higher doses of nicotinamide can result in more severe side effects like liver damage, but only very rarely and only in those individuals.It is crucial to consult your healthcare provider before beginning a nicotinamide supplementation regimen to ensure that it is appropriate for you.
Pharmacokinetics
Following oral administration, nicotinamide is quickly and completely absorbed from the digestive tract. Nicotinamide has a 100 percent bioavailability.
Nicotinamide is widely distributed throughout the body after absorption and is primarily excreted as metabolites in the urine. Nicotinamide has a half-life of 1-2 hours.
Indications
Vitamin B3 deficiency is frequently treated or prevented with niacinamide supplements. In accordance with your healthcare provider's recommendations, nicotinamide may also be used to treat other conditions.
Contraindications
If you have a nicotinamide allergy or sensitivity, avoid taking supplements containing it. Additionally, if you have a history of liver disease or other liver issues, you should refrain from taking nicotinamide.
If you are pregnant or nursing, you shouldn't take nicotinamide supplements unless your doctor instructs you to.
Side Effects
Supplemental niacinamide is typically well tolerated. Mild gastrointestinal upset is the most frequent side effect, which can be prevented by taking the supplement with food. Some people may experience skin flushing from nicotinamide. As long as the supplement is used regularly, this side effect should subside. Rarely, higher doses of nicotinamide can result in more severe side effects like liver damage, but only very rarely and only in those individuals.
You need to stop taking nicotinamide supplements and get medical help right away if you experience any severe side effects after doing so.
These additional nicotinamide negative effects are possible:
Nausea
Vomiting
Diarrhea
Headache
Dizziness
Jaundice, allergic reactions, and liver damage are rare nicotinamide side effects. You should stop taking nicotinamide supplements and consult your doctor if you experience any of these negative effects after doing so.
Interactions
Other medications, herbs, or vitamins you are taking may interact with niacinamide. Before beginning any new supplement, it is always advisable to talk to your doctor, especially if you are already taking other medications.
Some of the potential drug interactions of nicotinamide include
When combined with anticoagulants (blood thinners) like warfarin (Coumadin), nicotinamide may increase the risk of bleeding.
Diabetes drugs: Nicotinamide may enhance the effects of insulin and other diabetes drugs.
Drugs for high cholesterol: Nicotinamide may enhance the effects of statins and other drugs that lower cholesterol.
If you are taking any of these medications, avoid taking nicotinamide supplements without first consulting your doctor.
Additionally, if you have a history of liver disease or other liver issues, you should refrain from taking nicotinamide. If you are pregnant or nursing, you shouldn't take nicotinamide supplements unless your doctor instructs you to.
Benefits
Vitamin B3 deficiency is frequently treated or prevented with niacinamide supplements. In accordance with your healthcare provider's recommendations, nicotinamide may also be used to treat other conditions. Among nicotinamide's potential advantages are the following:
addressing or avoiding vitamin B3 shortage
reduction of cholesterol
Bringing down blood pressure
heart disease risk reduction
preventing cognitive deterioration brought on by aging
lowering the risk of developing specific cancers
There may be additional advantages of nicotinamide not covered here. Consult your doctor if you're thinking about taking a nicotinamide supplement to determine whether it's appropriate for you.
Dosage and Adminstration
500 mg of nicotinamide per day is the recommended dosage. However, depending on their unique needs, some people might need to take a higher or lower dose. To find out the ideal dose for you, consult your healthcare professional before taking nicotinamide.
You can buy niacinamide supplements as liquids, tablets, powders, and capsules. Depending on the form you are using, there will be a best way to take nicotinamide. Before taking nicotinamide, make sure to follow the directions on the product label or contact your healthcare provider. Speak with your healthcare provider if you have any questions about nicotinamide dosage.
What Is the Recommended Dosage of Nicotinamide?
The dosage of nicotinamide that is advised for you will vary depending on your age, health, and other medications you are taking, among other things. Before beginning any supplement, always consult your healthcare provider to make sure it is safe for you and to determine the right dosage.
Nicotinamide is typically taken in doses between 50 and 100 mg per day. However, based on your particular requirements, your healthcare professional might suggest a different dosage.
Start with a lower dose when taking nicotinamide supplements for the first time, then gradually increase it as tolerated. There are tablet, capsule, powder, and liquid forms of niacinamide supplements.
How Long Does It Take for Nicotinamide to Work?
Depending on why you are taking nicotinamide, its effects change. For instance, you might feel better a few days after starting nicotinamide if you're taking it to treat vitamin B3 deficiency. But it might take a few weeks before your deficiency symptoms get better.
It might take a few weeks or months before you start to feel any better if you're taking nicotinamide supplements to control your blood pressure or cholesterol.
Can I Overdose on Nicotinamide?
Nicotinamide overdose is a rare occurrence that most often occurs in users of extremely high doses of the supplement. When taken in accordance with suggested dosages, niacinamide is generally regarded as safe.
However, taking too much nicotinamide can have negative side effects, including headache, dizziness, nausea, vomiting, and diarrhea. You should stop taking nicotinamide supplements and consult your doctor if you experience any of these negative effects after doing so.
Seek immediate medical attention if you suspect a nicotinamide overdose.
What Are the Precautions of Nicotinamide?
When taken in accordance with suggested dosages, niacinamide is generally regarded as safe. Before taking nicotinamide, there are a few things to be aware of.
There could be interactions between nicotinamide and some drugs or supplements. Before beginning any new supplements, especially if you are taking any medications, be sure to consult your healthcare provider.
Be sure to consult your doctor before taking nicotinamide if you have liver disease or are taking medications that can harm the liver. Additionally, nicotinamide may make peptic ulcer symptoms worse.
Before taking nicotinamide, make sure to discuss your pregnancy or breastfeeding with your doctor. Children should not be given nicotinamide.
You can buy niacinamide supplements online, at a lot of pharmacies, and in many health food stores. Before taking any supplements, make sure to consult your doctor, especially if you have a medical condition or are already taking medication.