NAD+ (Nicotinamide Adenine Dinucleotide) Supplements

Support cellular repair, mitochondrial function and healthy ageing with NAD+ supplements — the scientifically validated foundation of human energy metabolism. At Welzo, we provide trusted NAD+ and NAD+ precursor supplements designed to restore cellular vitality, promote metabolic balance, and help you maintain peak performance at every age.

Understanding NAD+: The Molecule of Life

Nicotinamide Adenine Dinucleotide (NAD⁺) is a vital coenzyme found in every living cell. It powers more than 500 enzymatic reactions essential for energy production, DNA repair, gene regulation and cell survival.

As explained by Dr. Charles Brenner, PhD, a leading NAD+ researcher at Stanford University,

“NAD⁺ is the central catalyst of metabolism. When NAD⁺ levels decline, every aspect of cellular health is compromised — from mitochondrial function to DNA maintenance.”

With age, stress and environmental exposure, NAD⁺ levels naturally fall, leading to reduced energy, slower recovery and accelerated biological ageing. Supplementation with NAD⁺ or its precursors has emerged as one of the most researched strategies for restoring metabolic balance and promoting cellular longevity.

The Science of NAD+: Energy, Repair and Longevity

Cellular Energy and Mitochondrial Function

NAD⁺ acts as a key cofactor in the electron transport chain, the process by which mitochondria convert nutrients into ATP — the body’s primary energy currency. Without adequate NAD⁺, energy metabolism becomes inefficient, leading to fatigue, decreased endurance and metabolic slowdown.

According to Dr. David Sinclair, Professor of Genetics at Harvard Medical School,

“Restoring NAD⁺ levels in ageing cells is like recharging the battery of life itself. It reawakens dormant repair systems and enhances mitochondrial resilience.”

DNA Repair and Longevity Pathways

NAD⁺ activates two major classes of enzymes vital to longevity: sirtuins and PARPs.

• Sirtuins (SIRT1–SIRT7) regulate inflammation, stress response, and cellular repair.

• PARPs repair single-strand breaks in DNA caused by oxidative damage.

When NAD⁺ is depleted, DNA damage accumulates faster — a hallmark of ageing and chronic disease. By replenishing NAD⁺, these protective pathways can function more efficiently, supporting long-term cellular integrity.

Neuroprotection and Cognitive Vitality

The brain demands immense energy. NAD⁺ supports neuronal function by improving mitochondrial performance, enhancing neurotransmitter balance, and reducing oxidative stress. Early clinical research indicates NAD⁺ may improve mental clarity, focus and cognitive endurance, particularly under conditions of fatigue or stress.

Forms of NAD+ Supplements

Direct NAD+

Stabilised NAD⁺ capsules or sublingual forms deliver the molecule directly, allowing for faster bioavailability. Ideal for those seeking immediate mitochondrial and energy support.

NMN (Nicotinamide Mononucleotide)

A direct precursor in the NAD⁺ biosynthetic pathway. NMN converts efficiently into NAD⁺ within cells and has demonstrated promising results in metabolic and vascular health studies.

NR (Nicotinamide Riboside)

A vitamin B3 analogue clinically shown to elevate NAD⁺ levels and support muscle regeneration, insulin sensitivity, and brain function.

Synergistic Formulas

Advanced formulations often combine NAD⁺ precursors with resveratrol, pterostilbene or CoQ10, which enhance sirtuin activation and antioxidant protection.

Clinical Benefits of NAD+ Supplementation

Why NAD+ Levels Decline With Age

By the age of 50, NAD⁺ levels can be reduced by more than 50% compared to early adulthood. Chronic stress, sleep deprivation, alcohol intake and environmental toxins accelerate this depletion. Supplementing NAD⁺ or its precursors can help restore youthful cellular function and maintain healthy ageing.

How to Use NAD+ Supplements

• Dosage: Commonly 250–1000 mg daily of NMN or NR equivalents. Always follow product-specific guidance.

• Timing: Morning use may enhance daytime energy and circadian rhythm alignment.

• Consistency: Long-term use supports sustained NAD⁺ elevation and metabolic stability.

• Lifestyle synergy: Combine with balanced nutrition, sleep optimisation and regular exercise for best results.

Frequently Asked Questions

What is the most effective form of NAD+?

The most effective form depends on individual absorption and biological needs. NMN and NR are the most researched NAD⁺ precursors, with strong evidence showing they effectively raise intracellular NAD⁺ levels. Direct NAD⁺ formulations offer faster onset but may have variable stability in the digestive tract.

Is NAD+ just niacin?

No. Niacin (vitamin B3) is a precursor in the NAD⁺ synthesis pathway but is not the same molecule. NAD⁺ is the active coenzyme form that powers cellular metabolism. While niacin supports NAD⁺ production, supplements like NMN and NR provide a more direct and efficient route to replenishing NAD⁺.

Does NAD help with anti-aging?

Research suggests that boosting NAD⁺ levels may slow biological ageing by improving DNA repair, mitochondrial function, and metabolic efficiency. Clinical studies show NAD⁺ replenishment enhances markers of cellular health and longevity, although it should be viewed as a supportive measure, not a cure for ageing.

Is NAD good for pregnancy?

There is currently insufficient human research on NAD⁺ supplementation during pregnancy. Because NAD⁺ affects metabolic and epigenetic pathways, pregnant or breastfeeding individuals should avoid NAD⁺ supplements unless specifically advised by a healthcare professional.

Who should avoid NAD+?

People with active cancers, severe liver disease, or undergoing chemotherapy should consult their doctor before taking NAD⁺ supplements, as NAD⁺ can influence cell growth and repair pathways. Individuals on medication for diabetes, hypertension, or autoimmune conditions should also seek medical advice prior to use.

What does NAD Plus do?

NAD+ helps your cells make energy, repair DNA, and regulate metabolism. It supports mitochondrial function, reduces oxidative stress, and keeps your body’s systems working efficiently.

Who should not take NAD+?

No — not everyone should take NAD+. People who are pregnant, breastfeeding, have active cancer, severe liver disease, or are undergoing chemotherapy should avoid NAD+ unless prescribed by a doctor.

Is NAD+ just vitamin B3?

No. NAD+ is not vitamin B3. It is the active coenzyme your body makes from vitamin B3 precursors like niacin, nicotinamide riboside (NR), or NMN.

Does NAD+ raise testosterone?

No — current evidence does not show that NAD+ increases testosterone levels. It may support overall energy metabolism, but it is not a hormone booster.

How do you get NAD naturally?

Yes — you can support natural NAD+ production through healthy habits. Eat foods rich in niacin (like fish, chicken, and mushrooms), exercise regularly, sleep well, and avoid alcohol and smoking.

What is the downside of NAD?

Possible downsides include mild side effects such as nausea, fatigue, headache, or stomach discomfort. Long-term human research is still limited, and the supplements can be expensive.

Is NAD+ bad for the liver?

Generally, no. NAD+ and its precursors are usually safe for the liver in normal doses. However, very high doses of niacin (a vitamin B3 form) may cause liver strain, so medical guidance is advised.

What is the controversy with NAD+?

Yes — there is controversy about unproven anti-ageing claims. Some clinics promoted NAD+ infusions without sufficient clinical evidence, leading to regulatory concerns about exaggerated benefits.

What is the best form of NAD to take?

The best form depends on your goal. NMN and NR (nicotinamide riboside) have the strongest human research for safely raising NAD+ levels. Direct NAD+ products may work faster but can be less stable in the gut.

Does Jennifer Aniston take NAD?

Yes — she has mentioned using NAD+ IV therapy in interviews, but this is anecdotal. It is not proof of effectiveness or a medical recommendation.

Is NAD+ legal in the UK?

Yes — NAD+ and NR are legal in the UK. NMN is classified as a “novel food,” meaning it must be authorised before being marketed. It is not banned but restricted to regulated use.

Is NAD better than collagen?

No — NAD+ and collagen serve different functions. NAD+ supports cell energy and repair, while collagen helps skin, joints, and connective tissue. They can be used together for overall wellness.

Is NAD+ really worth it?

Yes — for some people. Many report more energy, focus, and recovery. However, results vary, and research is ongoing. It may be worth it if used as part of a healthy lifestyle.

Why is NMN banned in the UK?

It is not banned. NMN is classed as a novel food in the UK and EU, meaning it requires approval before sale. This is a regulatory process, not a prohibition.

Does NAD+ affect sleep?

Possibly yes. NAD+ supports your circadian rhythm and may help balance sleep-wake cycles, but research in humans is still limited.

Is NAD just vitamin B3?

No — NAD+ is made from vitamin B3, but it is not the same. NAD+ is the active molecule your cells use for energy and repair.

Does NAD get rid of saggy skin?

No — NAD+ does not tighten skin directly. It supports cell health and repair but does not replace cosmetic or dermatological treatments for sagging skin.

What should you not mix with NAD?

Avoid taking NAD+ alongside high-dose niacin, chemotherapy drugs, or immune-modulating medications unless advised by your doctor. Always consult a healthcare professional before combining supplements.

What two vitamins should not be taken together?

Iron and calcium should not be taken together because calcium can block iron absorption. Also, large doses of zinc can lower copper levels, so balance them if used long term.

Does NAD raise blood pressure?

No — NAD+ does not raise blood pressure. In some studies, NAD+ precursors may slightly lower blood pressure or improve vascular health.

What age should I start taking NAD?

Most adults may consider NAD+ support from their 30s to 40s, when natural levels start to decline. Always consult your healthcare provider before starting supplements.

Why Choose Welzo for NAD+ Supplements?

• Clinical oversight: Products reviewed by qualified medical professionals.

• Evidence-based sourcing: Only brands supported by peer-reviewed data.

• Transparency: Ingredient lists, purity reports and dosage accuracy available.

• Customer support: Guidance from our healthcare team on proper usage and interactions.

At Welzo, we believe in empowering your health through science, education and trust. Our NAD⁺ range bridges the gap between modern research and everyday wellness, helping you unlock your full potential — from cellular energy to longevity.

Summary

NAD⁺ is more than a supplement — it’s the biochemical key to sustained energy, cellular renewal and long-term vitality. Backed by decades of research and expert validation, NAD⁺ therapy represents a cornerstone of modern longevity science.

Replenish, restore, and revitalise from within.
Shop the NAD⁺ Supplement Collection at Welzo today and experience clinically guided cellular health.