Thorne 5-MTHF Methyl Folate delivers the bioactive folate your body can use right away to support methylation, mood and cellular function. The star ingredient, L-5-Methyltetrahydrofolate, is the active folate your body can use straight away to support mood, energy and cellular function. Thorne combines rigorous quality standards with transparent manufacturing, making this folate supplement trusted by health professionals.

Available Sizes & Variants:

30 vegan capsules - ideal monthly supply for daily use

Benefits & Features:

• Supports methylation for a steady mood.
• Intended for daily use, it provides the bioactive folate your body can use straight away, helping cellular function and cardiovascular health by supporting homocysteine regulation.
• Manufactured in USA facilities with third party testing to verify identity and purity.
• Particularly helpful for people with MTHFR variants who struggle with folate metabolism.
• Clinically aligned formulation supports steady daily methylation and energy, backed by Thorne’s commitment to purity, transparency, and rigorous quality controls.

Thorne's a science driven brand with a long history of clinical alignment and transparency; it's not just hype, it's real quality. This product is manufactured in USA facilities that are FDA registered and GMP certified, with third party testing for identity and purity. Each capsule contains 15 mg of 5-MTHF, a high potency option designed for clinical use under healthcare supervision. For a complete wellbeing routine, many customers pair this folate supplement with a vitamin d supplement and probiotics.

5-MTHF, Microcrystalline cellulose, hypromellose (derived from cellulose) capsule, leucine, silicon dioxide.

• GTIN: 693749006626
• Manufacturer: Thorne
• Categories: New ArrivalsOut of stockPopular Supplement BrandsThorne Supplements
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

The supplement can be consumed in the form of one capsule, and it is advised to take it one to three times a day. Alternatively, you can follow the suggestion of your health-care practitioner to determine the appropriate dosage. Adults take up to 6 capsules daily with food. Children 4-14 years of age take up to 3 capsules daily. Children less than 4 years of age use only as directed by a healthcare professional.

Please consult the product packaging for accurate instructions on how to use the product.

1) Promotes healthy brain function: 5-MTHF Methyl Folate is essential for the production of neurotransmitters, which play a crucial role in maintaining cognitive health and mood stability.
2) Supports cardiovascular health: This product helps to regulate homocysteine levels in the blood, which can reduce the risk of heart disease and stroke.

The Active Ingredient Is: L-5-Methyltetrahydrofolate (5-MTHF)

L-5-Methyltetrahydrofolate, also known as 5-MTHF, is the active form of folate used by the body in essential methylation processes and cellular function.

This form is the naturally occurring, readily utilised folate derivative that helps the body’s metabolic and genetic maintenance activities.

What Does L-5-Methyltetrahydrofolate Do?

5-MTHF takes part in methylation, a central process for DNA synthesis and neurotransmitter creation, and supports cardiovascular health by regulating homocysteine levels.

Scientific research suggests this active folate form could contribute to mood and cognitive function, with potential relevance for individuals with impaired folate metabolism. Dr. Scherer from a university found that active folate supports these functions in relevant studies.

This product is not intended to diagnose, treat, cure, or prevent any disease.

We picked Thorne as our trusted partner for 5-MTHF Methyl Folate because this brand stands out for its heritage as a science-driven, practitioner-preferred supplement manufacturer. Thorne is well established in the industry for quality, transparency and clinical alignment, and is stocked by respected medical channels such as the Mayo Clinic Store. This brand consistently positions itself above mass-market options through research-backed formulas and a clear commitment to ingredient purity.

Compared with competitors, Thorne’s manufacturing philosophy emphasises rigorous quality control, with FDA-registered facilities and GMP compliance guiding every batch. Their products undergo third-party testing for identity, potency and contaminants, reinforcing the trust clinicians and consumers place in the brand. We also value their openness, including full disclosure of non-medicinal ingredients and minimal excipients, which aligns with Welzo’s standards for safety and transparency. For those seeking expert-led guidance, this is the brand our medical team recognises as reliable and accountable our team of medical experts and our rigorous testing protocols.

Product-wise, Thorne’s commitment to providing the bioactive, methylated form of folate directly supports the intended use of 5-MTHF, with a clear focus on quality manufacturing and verified ingredient sourcing. This makes Thorne especially well suited for this high-potency, clinically oriented formulation.

Welzo’s brand evaluation process involved a careful review of reputation, manufacturing excellence and testing standards. The outcome is a selection that pairs a trusted brand with a product designed for safety, transparency and therapeutic credibility.