5-MTHF Methyl Folate helps support mood, heart and nerve function, delivering the bioactive folate for quicker absorption and effective daily support. It's particularly helpful for people with MTHFR gene mutations who may struggle to convert dietary folate into its active form. Metabolic Maintenance backs this with a professional grade formula, manufactured in a GMP compliant facility to ensure purity, potency and safety.

Available Sizes & Variants:

90 capsules - convenient daily dose for three months.

Benefits & Features:

• Active folate is ready to use.
• L-5-methylfolate supports mood, cardiovascular health and nerve function by providing the body with a directly usable folate form, reducing the need for enzymatic conversion and supporting neurotransmitter synthesis.
• Designed for those with MTHFR variations, it bypasses the need for conversion and delivers reliable folate bioavailability.
• GMP quality keeps this folate supplement pure.
• Free from gluten, dairy, eggs and nuts to suit common dietary needs and preferences.

Metabolic Maintenance has built its name on quality supplements produced in GMP facilities with strict checks. This folate supplement uses the bioactive L-5-methylfolate in a calcium salt, delivering about 8.3 mg of dietary folate equivalents per capsule and pairing it with 255-265 mg glycine for smooth absorption. The brand is known for transparent sourcing and routine third-party testing, and the formulation is gluten, dairy, egg and nut free, making it easy to fit into daily routines. And yes, it's a reliable partner when you're balancing focus, mood and energy, including alongside weight loss pills or probiotics for gut health.

L-methylfolate, calcium salt (Extrafolate S®, Gnosis Bio, Italy) and glycine are made by chemical synthesis.

• GTIN: 838287005315
• Manufacturer: Metabolic Maintenance
• Categories: Metabolic MaintenanceNew ArrivalsTENA
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one daily or as instructed. Take four capsules daily\, two in the morning and two in the evening or as directed

Please consult the product packaging for accurate instructions on how to use the product.

The Active Ingredient Is: Folate (L-5-Methylfolate)

Folate in its active, bioavailable form, L-5-methylfolate, is a water-loving B vitamin essential for normal metabolic functions and neural health. This product provides L-5-methylfolate supplied as a calcium salt for stability and bioavailability.

The form and source information reflect its clinically validated, readily absorbed active folate form used to support targeted dietary folate status.

What Does Folate Do?

Folate plays a role in normal brain function and nervous system maintenance and is involved in one-carbon metabolism as described in EFSA guidelines. Scientific literature suggests L-5-methylfolate can bypass certain metabolic conversions, supporting active folate availability in the body.

Dr. Giacone of the University found that L-5-methylfolate can support these physiological roles and may contribute to maintaining healthy methylation processes.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Metabolic Maintenance is our chosen partner for 5-MTHF Methyl Folate because this brand shows a deep, steady commitment to quality from the ground up. The manufacturer runs in a GMP-compliant facility, underscoring a solid track record of making pure, potent supplements that align with FDA-endorsed manufacturing practices. This brand's formulation is described as professional-grade, reflecting robust quality control and accurate label representation, supported by clear attestations to purity and safety. Their products are also manufactured to be gluten-, dairy-, egg-, and nut-free, which resonates with Welzo’s commitment to clean, well-tested supplements. We corroborate these standards through our internal evaluation and insistence on rigorous testing, as part of our overall quality approach to every partner. This brand’s capability and commitment were evaluated by our expert team of doctors, nurses, and nutritionists and are aligned with our ingredient quality and purity standards.

Metabolic Maintenance also highlights supply-chain integrity and third-party testing as part of its standard practice, reinforcing confidence in both product quality and safety. This makes them a standout pick for Welzo, especially for the British market where clear testing and provenance matter. For this reason, we suggest Metabolic Maintenance as the trusted brand for this active folate offering.