High Potency Optimised Folate is a folate supplement that supports healthy homocysteine metabolism and cardiovascular and neurological function for many adults aiming for optimum health. The star ingredient, L-5-MTHF, is the bioactive folate form, making absorption efficient even for those with common gene variants. Life Extension brings decades of expertise and strict quality standards to this trusted folate supplement.

Benefits & Features:

• Supports healthy homocysteine metabolism and cardiovascular health.
• L-5-MTHF is the active folate form, enhancing absorption for those with common gene variants.
• Plant based tablets for daily use.
• Designed with safety in mind and manufactured to strict quality standards.
• Life Extension's commitment to quality is evident in sourcing from the US, Japan and Europe and maintaining NSF registered GMP facilities, ensuring you receive a consistent, pure folate supplement you can trust.

Life Extension, founded in 1980, has built a reputation for quality across decades in the supplement world. The brand sources high quality raw materials from the US, Japan and Europe and runs GMP compliant production, NSF registered facilities. The featured ingredient, L-5-MTHF, is the bioactive folate form shown to raise folate status and lower homocysteine, supporting cardiovascular and brain health. With strong customer loyalty and recognition from ConsumerLab.com in 2024, this folate supplement stands out for reliability.

Folate (as L-5-methyltetrahydrofolate calcium salt)

• GTIN: 737870191339
• Manufacturer: Life Extension
• Categories: Best SellersNew ArrivalsSubscribe & Save Products
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one capsule daily, with or without food, or as directed by a healthcare professional. One or two capsules – or according to practitioner recommendation – in the morning.

Please consult the product packaging for accurate instructions on how to use the product.

The Active Ingredient Is: Folate (5-Methyltetrahydrofolate)

Folate, in its bioactive coenzyme form 5-Methyltetrahydrofolate, is a B vitamin essential for normal cellular functions including methylation and DNA synthesis. This form is more readily utilised by the body than synthetic folic acid, supporting metabolic processes involved in cardiovascular and neural health.

This form is the bioactive folate variant used by the body to support methylation and DNA synthesis, with sources including natural and fortified foods; research indicates superior blood folate status and homocysteine handling with 5-MTHF compared with folic acid.

What Does Folate (5-Methyltetrahydrofolate) Do?

Folate contributes to normal homocysteine metabolism and supports neural and cardiovascular health in line with EFSA guidance. The 5-MTHF form is associated with improved folate status and is a key participant in methylation pathways important for healthy brain function.

Dr. Scaglione of the University of Bologna found that 5-MTHF elevates serum folate levels and supports homocysteine regulation more effectively than folic acid, aligning with EFSA recommendations for folate function.

Life Extension shows a science‑led, quality‑first approach that aligns with Welzo’s commitment to reliable, evidence‑based supplementation. Founded in 1980, Life Extension is a seasoned brand with a long history in the industry, widely recognised by independent reviewers for product quality and customer loyalty, which supports our confidence in a dependable supplier partnership. The manufacturer’s reputation for sourcing high‑quality raw materials from the U.S., Japan and Europe, and producing under Good Manufacturing Practices (GMP) principles, reinforces the reliability of its portfolio and resonates with our standards. This brand is known for its rigorous quality orientation and ongoing emphasis on purity and potency, which we prioritise when selecting a partner. This brand was evaluated by Welzo's healthcare professionals for compliance with the certifications we require.