SAm e is a SAMe supplement designed to support mood health, ease joint discomfort, and promote healthy liver function for everyday wellbeing. A stabilised, enteric coated tablet helps protect SAMe from stomach acids and supports bioavailability. Jarrow Formulas is a trusted brand, known for pharmaceutical grade, stabilised SAMe and strict Good Manufacturing Practice standards. EnteroGuard and double sided foil packaging help keep potency fresh from manufacture to you.

Available Sizes & Variants:

60 tablets SAMe - convenient daily dose for ongoing support

Benefits & Features:

• Supports mood health.
• Supports joint comfort and mobility, helping you stay active with daily tasks as SAMe contributes to cartilage synthesis and the maintenance of healthy joints throughout the day.
• Intended for daily use to support mood, joint and liver health.
• Manufactured under Good Manufacturing Practice and packaged in double sided foil to preserve potency.
• The star ingredient SAMe fuels essential methylation reactions, supporting neurotransmitter production and detoxification in the liver, which helps keep everyday brain function humming and energy levels steady.

Jarrow Formulas sam e has earned a loyal following for purity and stability. The product is produced using Good Manufacturing Practice practices, a careful fermentation process, and a specialised enteric coating to protect potency. The EnteroGuard system and double sided foil packaging keep freshness intact, while vegetarian excipients make it accessible for many. This brand's standing commitment to quality helps it stand out, with many customers adding it to holistic routines that may include a vitamin d supplement or probiotics alongside sam e.

S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate)

• GTIN: 790011200420
• Manufacturer: Jarrow Formulas
• Categories: Best SellersJarrow FormulasOur Biggest Black Friday Sale!Sports Supplements Black Friday SaleSubscribe & Save Products
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take 1 tablet of Jarrow Formulas SAMe 400 daily on an empty stomach, preferably with a glass of water. Store in a cool, dry place away from direct sunlight. Keep out of reach of children. Consult a doctor before use if you are pregnant, nursing, taking medications, or have a medical condition. Do not exceed the recommended dose.

Please consult the product packaging for accurate instructions on how to use the product.

*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

The Active Ingredient Is: S-Adenosyl Methionine (SAMe)

S-Adenosyl Methionine, often called SAMe, is a naturally occurring compound involved in methylation processes that help normal cellular function.

This product offers SAMe in a stabilised, enteric-coated form and is produced from SAMe tosylate disulfate to maximise potency and bioavailability.

What Does S-Adenosyl Methionine (SAMe) Do?

SAMe is involved in methylation reactions that contribute to neurotransmitter synthesis and keeping joint tissue regeneration going, and it also supports liver detoxification processes in the body, in line with standard nutrient function concepts.

Dr. Mischoulon of Duke University found that SAMe supplementation can support mood health and joint mobility in clinical settings, reflecting its broader role in biochemical pathways that underpin these functions.

This supplement is not intended to diagnose, treat, cure, or prevent any disease.

Jarrow Formulas is our chosen partner for SAMe because this brand commitment to quality starts at the heart of its approach. The manufacturer is widely recognised for pharmaceutical grade, stabilised SAMe produced through a natural fermentation process, with strict low temperature and humidity controls that maximise potency and stability. This emphasis on stability is reinforced by advanced packaging and enteric coating, protecting the product from degradation and preserving bioavailability.

Welzo’s medical experts assessed Jarrow Formulas using our thorough criteria and affirmed their solid quality framework and manufacturing discipline. The brand’s facilities operate under GMP standards and employ environmental controls that support consistent product integrity, a factor that matters a lot for a stabilised, enteric-coated supplement like SAMe. For independent validation of quality, the brand has been cited as meeting high standards for digestibility, potency and purity by trusted sources, with ConsumerLab recognising their performance in these areas.

This synergy between Jarrow Formulas’ manufacturing excellence and SAMe 400’s formulation makes it a natural fit for this supplement category. Our team of medical experts and our quality assurance criteria both back this selection, ensuring a trustworthy partnership for Welzo customers. For more on our vetting process, see our team of medical experts and our quality assurance criteria.