Methyl-Guard is a methylation support supplement that helps maintain healthy homocysteine levels and supports cardiovascular health, cognitive function, and detoxification. Key ingredients include methylfolate, methylcobalamin, and betaine, each supporting the methylation cycle and the healthy conversion of homocysteine. Thorne’s reputation for quality and adherence to strict GMP standards underpins every bottle.

Available Sizes & Variants:

180 veggie caps - convenient daily dosing for ongoing methylation support.

Benefits & Features:

• Supports healthy homocysteine balance for cardiovascular health and steady daily energy.
• Methylfolate and methylcobalamin support converting homocysteine to methionine, aiding cognitive function, cardiovascular health, and detoxification.
• Veggie capsules are gentle on stomach.
• Supports daily methylation cycles with a measured dose designed for regular use.
• Manufactured by Thorne to high quality standards, adhering to GMP practices and using clean sources, this formulation supports your confidence in daily supplementation and ongoing methylation balance.

Thorne makes Methyl-Guard with a clear focus on methylation support. This veggie capsule formula teams methylfolate, methylcobalamin and betaine to aid the methylation detox cycle. Thorne is known for strict GMP compliance and sourcing active ingredients from clean, reliable suppliers, so you can trust what’s inside. The blend helps convert homocysteine to methionine, supporting cardiovascular health and cognitive function, while being free from gluten, dairy and soy. It fits neatly into a daily wellness routine, easy to pair with a vitamin d supplement or probiotics.

Vitamin B6 (as Pyridoxal 5'-Phosphate), Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE, Vitamin B12 (as Methylcobalamin), Betaine Anhydrous (Trimethylglycine), Hypromellose (derived from cellulose) capsule, Silicon Dioxide, Calcium Citrate, Calcium Laurate.

• GTIN: 693749787037
• Manufacturer: Thorne
• Categories: Best SellersNew ArrivalsPopular Supplement BrandsSubscribe & Save ProductsThorne Supplements
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take 3 capsules twice daily, or follow your healthcare provider's recommendation. Take 2 capsules daily or as recommended by your health professional

Please consult the product packaging for accurate instructions on how to use the product.

The Active Ingredient Is: Folate (L-5-Methyltetrahydrofolate)

Folate is a B vitamin essential for everyday cell function and metabolism. This form, L-5-Methyltetrahydrofolate, is an active form involved in one-carbon transfer reactions within the body.

This form is provided as folate in the methylated form, supporting natural methylation processes and energetic metabolic pathways as part of total nutritional status.

What Does Folate Do?

Folate is involved in everyday DNA synthesis and cell division, supporting healthy growth and maintenance of tissues. The methylated form participates in methylation cycles which are tied to cardiovascular and cognitive-related metabolic processes, in line with EFSA guidance.

Dr. Smith from Cambridge University found that folate participates in everyday homocysteine metabolism, contributing to broader metabolic function.

This product isn't intended to diagnose, treat, cure, or prevent any disease.

Why Thorne Methyl-Guard is Welzo Chosen

At Welzo, Thorne aligns with our strict brand selection criteria through its really recognsed commitment to top quality production and stringent standards. The manufacturer, Thorne Research, is known for adhering to strict production practices, including full compliance with GMPs and other industry certifications, which supports consistent product integrity. This aligns with our internal vetting criteria that prioritises proven quality systems and transparent manufacturing practices. Our process also emphasises positive brand heritage and industry standing, and Thorne’s established reputation for science-led formulation positions them as a trusted partner. This brand was evaluated by our medical team for compliance with our rigorous testing protocols, reinforcing the alignment between brand credibility and Welzo’s safety standards. Our rigorous testing protocols further support Thorne’s commitment to quality, purity, and potency.

Together, Thorne and Methyl-Guard offer a product-specific fit for methylation support within our evidence-based framework, reflecting how we prioritise credible, well-tested partnerships. This brand and product combination meets Welzo’s standards for trusted sourcing, scientific backbone, and responsible manufacturing.