Methyl-Guard Plus is a methylation support supplement that aids healthy methylation, backs cardiovascular function, and boosts cognitive health through its active, methylated vitamin blend. This is methylation support you can rely on. Bioavailability is a key strength. And Thorne's quality shines through, with many customers pairing it with probiotics or prenatal vitamins for broader wellness. Only active methylated B vitamins are used for fast absorption. Thorne is a trusted name in high quality supplements.

Available Sizes & Variants:

90 vegetarian caps – easy daily dose for ongoing methylation support

Benefits & Features:

• Supports balanced methylation for steady energy and mood.
• Active forms of folate and vitamins B promote fast absorption and bioavailability.
• Key actives include L-5-MTHF, methylcobalamin, pyridoxal 5'-phosphate, riboflavin 5'-phosphate and betaine, all chosen for rapid methylation support and healthy blood vessel function, supporting cardiovascular comfort and cognitive vitality.
• Stringent quality testing across raw materials, during processing and the finished product helps ensure purity, potency and safety.
• Designed for daily use with methylated vitamins to ensure fast, reliable bioavailability and steady support.

Thorne is trusted by healthcare professionals worldwide for their quality, purity, and efficacy. Methyl-Guard Plus provides active methylated B vitamins for fast, reliable absorption. Thorne’s GMP certified facilities run four rounds of in-house quality control to verify purity, potency and identity. The brand’s long history of collaboration with top research institutions underscores its commitment to targeted methylation support for cardiovascular and cognitive health.

Betaine Anhydrous (Trimethylglycine) Folate (L-5-MTHF) Vitamin B12 (Methylcobalamin) Vitamin B2 (Riboflavin 5'-Phosphate Sodium) Vitamin B6 (Pyridoxal 5'-Phosphate), Other Ingredients: Calcium (Citrate), Calcium Laurate, Hypromellose Capsule

• GTIN: 693749789017
• Manufacturer: Thorne
• Categories: New ArrivalsPopular Supplement BrandsThorne Supplements
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Consume 1-3 capsules per day or follow the advice of your healthcare provider. As a dietary supplement\, take 3 capsules daily.

Please consult the product packaging for accurate instructions on how to use the product.

1. Methyl-Guard Plus by Thorne Research is a comprehensive supplement that provides a variety of health benefits, including supporting healthy cardiovascular function, promoting a healthy mood, and supporting proper nerve function.
2. This product contains key nutrients, such as B vitamins, folate, and betaine, that support methylation, a crucial process in the body that helps regulate gene expression and neurotransmitter production. This can help improve overall cognitive function and mental health.

The Active Ingredient Is: L-5-Methyltetrahydrofolate

L-5-Methyltetrahydrofolate is essentially the active, methylated form of folate, a B vitamin cofactor crucial for everyday body functions. This very bioavailable form supports ready utilisation in metabolic processes.

This formula also includes methylcobalamin and betaine to support methylation pathways, boosting the coordinated action of methyl donors and cofactors for easier utilisation.

What Does L-5-Methyltetrahydrofolate Do?

L-5-Methyltetrahydrofolate participates in normal methylation and helps maintain normal homocysteine levels in the body, as noted in clinical research. Dr. Lonn from Mayo Clinic found that active folate can contribute to these metabolic processes linked to cardiovascular and cognitive health considerations.

In addition, folate functions alongside other methylation nutrients to support normal metabolism and physiological roles recognised by EFSA guidelines.

This supplement is not intended to diagnose, treat, cure, or prevent any disease.

Thorne is our go-to partner for Methyl-Guard Plus because this brand consistently demonstrates industry-leading quality, scientific rigour and global clinical credibility. Thorne has earned a reputation as a globally respected leader in supplements, collaborating with leading institutions like the Mayo Clinic and NIH, which reinforces the trust we place in their research-backed formulations. The manufacturer also maintains strong regulatory standing, including GMP-certified facilities and an A-grade endorsement from Australia’s TGA, underscoring their manufacturing excellence and safety commitments. Our medical team reviews such credentials as part of our rigorous evaluation process, supported by our medical team and our rigorous testing protocols to ensure alignment with Welzo standards.

Thorne’s product philosophy centres on active, methylated forms of B vitamins and betaine, which supports high bioavailability and reliable lab-tested potency. This aligns perfectly with Methyl-Guard Plus, a targeted methylation support option that emphasises purity, identity, and stability. When compared with other suppliers, Thorne’s long-standing heritage, global trust among healthcare professionals and comprehensive quality controls distinguish them as the ideal supplier for this specific supplement.

Welzo selected Thorne because their established credibility, documented testing practices and commitment to safety meet our team’s exacting criteria. This brand is particularly well-suited for Methyl-Guard Plus, given their emphasis on active, methylated nutrients and robust QC processes that help ensure consistent product quality for consumers.