SAM-e (S-Adenosyl-L-Methionine) helps support joint comfort, mood balance, and liver vitality, with an enteric coated tablet built for improved absorption and stability. This key active ingredient, SAM-e, is a natural methyl donor connected to supporting joint comfort, mood stability, and liver detoxification. From Jarrow Formulas, a brand known for science-led formulations and careful manufacturing, the enteric coating helps SAM-e survive stomach acid and reach absorption.

Available Sizes & Variants:

30 enteric coated tablets; convenient daily supply designed for easy dosing.

Benefits & Features:

• Supports joint comfort and mobility.
• Enteric coating maximises absorption for steadier and more reliable support.
• Mood balance is aided by SAM-e through neurotransmitter pathways.
• Liver vitality may improve as detoxification becomes more efficient.
• Taking SAM-e on an empty stomach helps the active (S,S) form survive stomach acid and reach the small intestine, where absorption supports daily joint comfort, mood balance, and liver vitality.

Jarrow Formulas has built a reputation on science led supplements, and SAM-e is no exception. The product is produced via natural fermentation and manufactured under cool, controlled conditions to preserve stability; it's foil blister packed to guard against degradation. The formula preserves 68–80% of the biologically active (S,S) SAM-e form, helping real everyday benefits feel more reliable. This vegan, gluten-free tablet slots neatly into daily wellness routines alongside probiotics. sam e is the handshake word many customers recognise. This isn’t a vitamin d supplement; it’s SAM-e.

(other) Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch, glycolate an enteric coating (modified cellulose, magnesium silicate, triethyl citrate, and riboflavin.

• GTIN: 790011200208
• Manufacturer: Jarrow Formulas
• Categories: Jarrow FormulasNew Arrivals
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one tablet daily on an empty stomach, or as advised by your healthcare professional. Take one capsule daily or as directed

Please consult the product packaging for accurate instructions on how to use the product.

The Active Ingredient Is: S-Adenosyl-L-Methionine (SAM-e)

SAM-e, short for S-Adenosyl-L-Methionine, is a natural compound involved in methylation and cellular upkeep. This product delivers SAM-e in an enteric-coated form to maximise stability and absorption, with the active material sourced from SAM-e tosylate disulfate. The formulation supports vegan, gluten-free diets and is designed to shield the active form through the digestive tract.

This section explains SAM-e and its vehicle; enteric coating helps ensure the active form survives stomach acid and releases in the intestines, supporting its role in normal cellular methylation processes.

What Does S-Adenosyl-L-Methionine (SAM-e) Do?

SAM-e participates in methylation reactions that help produce connective tissue components, neurotransmitters, and detoxification pathways. Studies suggest it may play a role in mood and liver-related processes, with enteric delivery supporting bioavailability.

Dr. Papakostas of Harvard University found that SAM-e augmentation may influence neurotransmitter activity linked to mood, illustrating its potential function within recognised cognitive and hepatic pathways.

This supplement is not intended to diagnose, treat, cure, or prevent any disease.

We chose Jarrow Formulas for SAM-e because this brand shows a solid commitment to natural sourcing and careful manufacturing that sits with Welzo's quality standards. Jarrow Formulas highlights a fermentation-based production process described as natural biological fermentation, backing our belief in minimally processed active ingredients. The brand also notes stability-minded production carried out under controlled low temperature and humidity, using foil blister packaging to guard SAM-e from degradation over time. These practices mirror a steady quality mindset that resonates with our standards for purity and potency.

From a testing and certification perspective, Jarrow Formulas uses enteric coating to maximise bioavailability and protect the product in the digestive tract, ensuring the active form is delivered as intended. This product is vegan, gluten-free and free from major allergens, which makes it suitable for a wide range of consumers. This alignment with our the certifications we require underpins our decision to partner with them for this supplement. Our team of medical experts trusts this brand for high quality standards.