Menopause 731 is a menopause supplement that aims to ease 11 common symptoms, bringing relief from hot flashes, night sweats, mood swings and sleep disturbances. The star ingredient is standardised Siberian rhubarb root extract used in a 4 mg daily dose. It quickly and easily helps offset discomfort across multiple menopausal symptoms. Life Extension backs it as part of their menopause supplements, with trials on over 400 women lasting 12 weeks to two years.

Available Sizes & Variants:

30 enteric-coated vegetarian tablets - daily dose for steady relief across 11 symptoms

Benefits & Features:

• Delivers steady relief from up to 11 symptoms.
• Hormone-free and soy-free for daily sensitive use, offering peace of mind.
• Star ingredient activates estrogen receptors to help mimic natural estrogen responses.
• Designed for convenience, a single daily tablet fits into busy routines, offering reliable symptom control without hormones while maintaining consistent levels throughout the day.
• Enteric coating protects the active compounds from stomach acid, helping ensure the rhubarb extract reaches the gut where it can be absorbed effectively, supporting consistent day-to-day comfort within the menopause supplements range.

Life Extension's Menopause 731 draws on decades of evidence based formulation. The star ingredient is standardised Siberian rhubarb root extract used in a 4 mg daily dose. It quickly and easily helps offset discomfort across multiple menopausal symptoms. This product sits within Life Extension's menopause supplements and broader wellness lines, with trials on over 400 women lasting 12 weeks to two years, well, basically anyone can benefit.

ERr 731® siberian rhubarb (Rheum rhaponticum L.) extract (root) [std. to > 54% rhaponticin, > 27% desoxyrhaponticin] 4 mg
Other ingredients: microcrystalline cellulose, stearic acid, croscarmellose sodium, silica, enteric coating (ethylcellulose, sodium alginate, medium chain triglycerides, oleic acid).

• GTIN: 737870220435
• Manufacturer: Life Extension
• Categories: Life ExtensionMenopause Supplements & ProductsNew Arrivals
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Consume one (1) tablet per day, or as advised by a medical professional.

Please consult the product packaging for accurate instructions on how to use the product.

1. Helps reduce the frequency and severity of hot flashes: Menopause 731 contains a blend of natural ingredients such as black cohosh extract and soy isoflavones that have been shown to alleviate hot flashes, one of the most common symptoms of menopause.
2. Supports bone health: Menopause 731 also contains calcium and vitamin D, essential nutrients for maintaining strong and healthy bones. This can be especially beneficial for women going through menopause, as hormonal changes during this time can increase the risk of osteoporosis.

The Active Ingredient Is: Siberian Rhubarb Root Extract

Siberian rhubarb root extract is a plant-based herbal extract that taps into bioactive compounds which interact with hormonal pathways. The extract in this product is standardised to deliver key constituents from the root of Rheum rhaponticum.

This form is prepared as an enteric-coated vegetarian preparation to help stable delivery of the active constituents and to keep product integrity through the digestive tract.

What Does Siberian Rhubarb Root Extract Do?

It selectively activates estrogen receptors in a way that can mimic certain natural estrogen responses, which may help offset hormonal imbalance during menopause. This mechanism supports normal hormonal regulation according to EFSA guidance.

In clinical settings, use of this extract has been linked to addressing various menopausal discomforts, while the formulation combines this primary ingredient with components that support its role in hormone-related pathways.

*This product is not intended to diagnose, treat, cure, or prevent any disease.

Life Extension has earned Welzo’s trust through a genuine commitment to quality and evidence-based innovation. The brand’s approach to menopause support is positioned as a best-in-class option within its own range, emphasising rigorous evaluation and a science-led presentation of clinical data. This reputation for thoughtful formulation and clear, research-informed messaging is central to why we chose Life Extension as our supplier for Menopause Relief.

Life Extension demonstrates product-specific capability with a carefully standardised Siberian rhubarb extract delivered at a 4 mg daily dose in Menopause 731. The extract is designed to selectively trigger estrogen pathways via ER-β, a mechanism that aligns with the brand’s emphasis on focused, well-characterised ingredients. This formulation approach reflects Life Extension’s long-standing focus on potency, consistency and reliable outcomes, which we value a lot for this type of supplement.

Our selection is strengthened by Welzo’s vetting process, where our medical team carefully evaluates brands for integrity and safety. We trust Life Extension to meet our strict quality standards, and we back this up with our rigorous testing protocols our rigorous testing protocols and insights from our medical team in collaboration with our product specialists.