Life Extension High Potency Optimized Folate is a vegetarian supplement that delivers highly bioavailable 5-MTHF to support cardiovascular and brain health. The key active ingredient is 5-MTHF as a calcium salt, designed to bypass common conversion hurdles and bolster folate status. Life Extension upholds strict quality standards with third party testing and GMP certification, and the product is non-GMO and gluten free, reflecting its purity and safety.

Available Sizes & Variants:

30 vegetarian tabs - convenient daily dose in a compact, easy-to-take format.

Benefits & Features:

• Boosts folate status for daily wellbeing.
• Premium 5-MTHF calcium salt bypasses common enzyme blocks, delivering reliable folate support even for those with MTHFR variations, supporting cardiovascular and nervous system health and wellbeing.
• Manufactured to strict quality standards with third party testing and GMP certification.
• Gluten free and non-GMO status underlines purity and safety.
• Compared with folic acid and other forms, 5-MTHF raises folate status more effectively, aiding cardiovascular health and brain function.

Life Extension has earned a reputation for rigorous quality and clear science. The star ingredient here is 5-MTHF, a highly bioavailable folate that bypasses the conversion hurdles of folic acid and directly supports the methylation cycle. This formula is Non-GMO and gluten free, with third party testing and GMP certification to back up purity. It’s a trusted option for folate support as part of a broader wellness routine, including prenatal vitamins and a vitamin d supplement.

Folate as (6S)-5-Methyltetrahydrofolic acid, calcium salt, Folate as (6S)-5-Methyltetrahydrofolic acid, calcium salt

• GTIN: 737870191339
• Manufacturer: Life Extension
• Categories: Best SellersLife ExtensionSubscribe & Save Products
• Best buy: 6 - 24 months+

United Kingdom Shipping:

Orders placed by 2pm (Monday to Friday) are dispatched the same day. Orders placed after 2pm will be dispatched the next working day.

Free shipping on orders over £50 to the UK.

Returns: Our products are meant to make you feel healthy and at your best. If you need to return your item, you can do so free of charge within 30 days in the same original and unopened packaging. Subject to T&C's.

Take one (1) tablet daily with food, or as recommended by a healthcare practitioner. Store in a cool, dry place, away from direct sunlight and out of reach of children. Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs. Do not exceed the recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Please consult the product packaging for accurate instructions on how to use the product.

*Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

Folate, the active, bioavailable form of vitamin B9, is a water-soluble nutrient involved in DNA synthesis and methylation processes. This version is highly bioavailable and comes as the calcium salt for stability and uptake.

Folate plays a part in the methylation cycle and helps DNA synthesis and cellular repair, helping nudge homocysteine levels in the body.

This role helps to support normal cell function and adds to overall cardiovascular and nervous system health considerations.

This product isn't meant to diagnose, treat, cure, or prevent any disease.

Life Extension remains Welzo’s trusted pick for High Potency Optimized Folate because of its long history of production excellence, quality stewardship, and customer safety. The brand consistently stresses strict quality assurance routines and third-party testing alongside GMP certification, underpinning a solid manufacturing framework you can rely on. This purity focus is reinforced by Non GMO LE Certified and Gluten Free status, showing careful material selection and process controls that match our standards.

Our vetting criteria recognise a manufacturer with clear quality credentials, transparent testing protocols, and a proven manufacturing heritage. Life Extension embodies these strengths, placing it ahead of competitors through a track record of rigorous QA and regulatory compliance that we can confidently stand behind. This makes Life Extension an ideal partner for a high‑potency 5‑MTHF folate formulation, where reliability and consistency are essential.

This brand was evaluated by our expert team of doctors, nurses, and nutritionists for compliance with our supplement quality standards. The collaboration is powered by our careful selection process and ongoing commitment to transparent, science‑led supplementation.