Videx
Health Benefits
Human immunodeficiency virus (HIV) infection is treated with videx. Additionally, videx is occasionally combined with additional drugs to treat hepatitis B.
Side Effects and Risks
The most frequent side effects of Videx are nausea, vomiting, diarrhea, and headache. Dizziness is another side effect of viex. If you combine Videx with alcohol or other drugs that make you sleepy, this effect could be exacerbated. Driving and using large machinery should be avoided until you understand how Videx affects you. Among Videx's other detrimental side effects are:
• Pancreatitis (pancreatic inflammation)
• Lactic acidosis, which is the accumulation of lactic acid in the blood
• Peripheral neuropathy (damage to the nerves)
• Hepatotoxicity (damage to the liver)
Low red blood cell count, or anemia
Skin rash
Before beginning treatment, discuss the potential side effects of Videx with your doctor.
Dosage
For adults, 200 mg of Videx taken twice daily is the recommended dosage. Weight-based recommendations apply to children between the ages of 3 and 18. The standard starting dose is 8 mg/kg (up to 200 mg) administered twice daily.
You can take Videx either with or without food. It is possible to take Videx with food if you have stomach discomfort.
Drug Interactions
Other medicines and Videx may interact. Inform your doctor about all prescription, over-the-counter, and dietary supplements you are taking. The following drugs shouldn't be taken with Videx:
• Live Adenovirus type 5 vaccine
(Live) vaccine for yellow fever
Live rotavirus vaccine (Rotarix, RotaTeq)
• Retrovir® (zidovudine)
(Zerit) Stavudine
Didanosine, sold as Videx and Videx EC
• Lamivudine (Epivir and Epivir-HBV)
• Tenofovir/emtricitabine (Atripla, Complera, Truvada)
(Viread) tenofovir disoproxil fumarate
(Complera) emtricitabine, rilpivirine, and tenofovir disoproxil fumarate
Atripla, a combination of efavirenz, tenofovir, and emtricitabine
• Edurant (rilpivirine)
(Sustiva, Atripla) Efavirenz
• Zovirax (acyclovir)
Famvir (famciclovir)
Valtrex (valacyclovir)
• NebuPent, also known as pentamidine
If you are taking any of these medications, let your doctor know. Your dosage may need to be changed, and your doctor may need to keep a closer eye out for any side effects. Additionally, Videx may interact with:
• Pills or a patch for birth control
• Benemid (probenecid)
• Coumadin (warfarin)
Mechanism of Action
The medication Videx is a member of is known as an NRTI (nucleoside reverse transcriptase inhibitor). Reverse transcriptase, an enzyme required for viral replication, is inhibited in order for the medication to work.
Pharmacokinetics
Videx is quickly absorbed from the digestive system and reaches its peak levels in 1 to 4 hours. Videx has a bioavailability of about 60%. With a volume of distribution of about 140 L, videx is widely distributed throughout the body. Plasma proteins are 96% bound to videx.
Nucleoside phosphorylase converts videx to 2′-3′-dideoxyinosine monophosphate (ddI-MP). Adenosine deaminase converts ddI-MP to 2′,3′-dideoxyinosine (ddI) through further metabolization. Urinary excretion is the main method of ddI elimination.
Videx has a half-life that varies from 1.5 to 4 hours.
Urinary excretion of videx as ddI is its primary route of elimination. Only 5% of the dose is excreted in the urine unaltered.