Enalapril and hydrochlorothiazide make up the medication known as Uniretic, which is used to treat hypertension (high blood pressure). The generic version of uniretic is offered. This guide's informational purpose is to aid in Welzo users' comprehension of Uniretic.

Health Benefits

The Uniretic ACE inhibitor component relaxes blood vessels, which lowers blood pressure. The thiazide diuretic component aids in the body's removal of extra salt and water.

Side Effects

The most frequent adverse reactions to Uniretic include:





constipation or diarrhea

dizziness or vomiting

joint or muscle pain

Among the less frequent side effects are:

body rash

changes in preference

excessive thirst or urination

reduced sexual capacity

Loss or gain of weight

liver function tests that are abnormal


uncommon negative effects include:

Swelling of the face, tongue, throat, arms, hands, feet, ankles, or lower legs is known as angioedema.

Jaundice is a yellowing of the skin or eyes.

Stop using Uniretic and get immediate medical help or call your doctor if you experience any of the following serious side effects:


Enalapril 10 mg/hydrochlorothiazide 12.5 mg, Enalapril 20 mg/hydrochlorothiazide 12.5 mg, and Enalapril 20 mg/hydrochlorothiazide 25 mg are the strengths of Uniretic that are available as tablets. One tablet taken once daily is the typical starting dose. If necessary, your doctor might raise your dose.

Enalapril 40 mg/hydrochlorothiazide 25 mg per day is the maximum dose advised. In order to lower the possibility of stomach upset, uniretic should be taken with food.

Take your missed Uniretic dose as soon as you remember. Skip the missed dose and resume your regular dosing schedule if your next dose is almost due. Never combine two doses at once.


Other blood pressure medications, lithium, potassium supplements, potassium-containing salt substitutes, insulin or oral diabetes medications, steroids, or probenecid may interact with uniretic. Any medication you take should be disclosed to your doctor. Only when it is prescribed during pregnancy must uniretic be used. This medication can negatively impact a nursing infant because it is excreted in breast milk. Before breastfeeding, speak with your doctor.

Mechanism of Action

Uncertainty surrounds the ACE inhibitor component of Uniretic's mechanism of action. It is believed to function by preventing the production of angiotensin II, a potent vasoconstrictor, from angiotensin I. By preventing electrolyte reabsorption in the distal tubule, the thiazide diuretic component of Uniretic causes an increase in sodium and chloride excretion. Additionally, this causes a rise in potassium excretion.


The gastrointestinal tract quickly and completely absorbs uniretic. The liver converts the Uniretic's ACE inhibitor component into active and inactive metabolites. The liver also processes Uniretic's thiazide diuretic component. The half-life of uniretic is approximately 11 hours.

Alternatives to Uniretic

To treat hypertension, there are numerous other medications available. Typical substitutions for Uniretic include:

Zestril (lisinopril)

lotensin (benazepril)

(Capoten) captopril

(Monopril) fosinopril

(Univasc) moexipril

Aceon's perindopril

Accupril (quinapril)

(Altace) ramipril

(Mavik) trandolapril

These drugs all have comparable side effects and similar mechanisms of action. Depending on your particular medical requirements, your doctor will decide what course of action is best for you.