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Tadalafil is a medication that is used to treat erectile dysfunction. This medication works by increasing the blood flow to the penis, which helps men to achieve and maintain an erection.

Tadalafil is available to buy in the UK in the following dosages: 2.5mg, 5mg, 10mg and 20mg.

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Nathalie Hayek reviewed
"Customer service was quick to respond and medication arrived the very next day!"
Anthony Limasol reviewed
"Quick, fast and reliable service. Use Welzo monthly for my medication."
Remeece Freeman reviewed
"No fuss, and fast delivery. Welzo dispatched my order the same day and it arrived in the morning."
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Description of Tadalafil

Tadalafil for Erectile Dysfunction

Erectile dysfunction, also known as impotence, is a common concern for men aged over 40. Tadalafil is a prescription medication available for men aged over 18 that is used to treat the symptoms of ED.

ED is most commonly caused by the vasoconstriction of the blood vessels of the penis. When these blood vessels are constricted, less blood is able to flow to the penis and erection problems occur.  

This ED medication is only available with a prescription but requires sexual stimulation to be effective. It is recommended to engage in foreplay to become properly stimulated.

What is Tadalafil and how does it work?

Tadalafil is the name of an active ingredient which is part of a group of medicines called phosphodiesterase type 5 inhibitors. This type of medication requires sexual stimulation to become effective at treating erection concerns.

Tadalafil will relax the blood vessels in the penis, which allows blood to flow and an erection to occur. This medication is suitable for those who have a range of erectile problems, including those who cannot get an erection or keep one long enough for sexual activity.

Tadalafil is also useful in treating other conditions along with erectile dysfunction. Please consult a Doctor, a Pharmacist or relevant product literature for more information.

Is Tadalafil right for me?

If you suffer from erectile dysfunction (impotence), Tadalafil may be an effective treatment. However, it may not be suitable for you if you have the following:

  • If you have galactose intolerance 
  • If you have severe heart, liver or kidney problems
  • If you have blood pressure concerns
  • If you have non-arteritic anterior ischemic optic neuropathy
  • If you are taking riociguat 

Tadalafil Side Effects

All medications can cause potential side effects, below we have listed some potential side effects of Tadalafil. However, these do not always occur and are mostly mild in nature. But if you experience any prolonged or worrying side effects of Tadalafil, please discontinue the medication immediately and consult your doctor.

Common side effects include:

  • Headache
  • Back pain
  • Muscle aches
  • Pain in arms and legs
  • Facial flushing
  • Nasal congestion
  • Indigestion

Tadalafil Additional Information

Tadalafil is available by prescription only, so make sure to speak to your doctor before starting treatment. Tadalafil is available in both pill and liquid form, and can be taken with or without food. Be sure to follow all of the dosage instructions provided by your doctor, as taking too much tadalafil can result in serious side effects.

Although Tadalafil is a safe and effective medication, there are some potential side effects that you should be aware of. These include headache, dizziness, and muscle pain. If you experience any of these side effects, stop taking Tadalafil and speak to your doctor.

How to take Tadalafil?

Always take Tadalafil exactly as prescribed by your doctor or advised by the pharmacist. The recommended starting dose is 10mg (for when required tablet) and 5mg (for daily dose tablet), however, in presence of other factors, this may be increased or decreased accordingly as per the prescriber's clinical judgement.

  • Tadalafil 10mg: one 10mg tablet at least 30 minutes before sexual activity.
  • If needed, dose can be increased to 20mg (2 tablets) as a single dose. 
  • Maximum one dose (20mg) in 24 hours (effects can last up to 36 hours). 
  • Swallow whole with water
  • Do not take medicine more than once a day.
  • Tadalafil 10mg and 20mg are not recommended for continuous daily use.

Once a day dosing of Tadalafil tablets may be prescribed for men who anticipate having sexual activity two or more times per week. These daily doses can allow you to obtain an erection (when sexually aroused) at any time during the 24 hours of the day. 

If you are taking a frequent dose of Tadalafil, e.g. at least twice a week, your doctor may instruct you to take a lower dose (2.5mg or 5mg) once daily. This dose should be taken at approximately the same time of day. 

  • Tadalafil 2.5mg: 1 or 2 tablets daily at the same time of day. 
  • Tadalafil 5mg: 1 tablet daily at the same time a day
  • This can take 2-3 days for effects to start. 
  • Swallow whole with water. 
  • Do not take tablets more than once a day.

Only 1 dose of Tadalafil should be taken in 24 hours. The effect of this medicine may be effective for 36 hours after taking the initial dose.

Tadalafil Warnings and precautions

Tadalafil may not be safe if taken with other medication or recreational drugs. Please inform the prescriber if you are taking any of the listed medications or have any of the following conditions:

DO NOT take Tadalafil:

  • If you've ever had an allergic reaction to Tadalafil or any other ingredients listed in this medicine
  • If you are taking medicines called nitrates for angina (chest pain) or amyl nitrates (poppers)
  • If you are taking riociguat
  • If you are taking any alpha-blockers such as Doxazosin, Tamsulosin 
  • If you are taking medications to treat high blood pressure
  • If you are taking a 5 - alpha reductase inhibitor used to treat benign prostatic hyperplasia
  • If you are taking medicines such as ketoconazole tablets and protease inhibitors used for the treatment of fungal infections, AIDs and HIV 
  • If you are taking anticonvulsant medicines, such as phenobarbital, phenytoin and carbamazepine
  • If you are taking anti-fungal or antibiotics such as rifampicin, erythromycin , clarithromycin or itraconazole.
  • If you are taking other ED medications

The above-listed warnings are not exhaustive, please consult a doctor, pharmacist or nurse if you have further questions on the use of this medication or potential interactions with other medicines.

Delivery of Tadalafil

Next Day Delivery Guarantee

All orders placed before 14:00 on weekdays will be delivered the next working day. For the majority of the UK, medication will be dispatched by Royal Mail, Monday to Friday, if ordered before 14:00. Dispatches are sent using Royal Mail's Next-Day Tracked 24-Hour service. We will email you tracking information directly and you should receive your order the day after dispatch.

Our Discreet Packaging Promise

We know that many of our customers turn to us when they need personal medication, preferring to use our online service rather than shopping for the product face to face. That is why our delivery is always discreetly packaged in plain brown boxes or envelopes. You will not have to worry about any content descriptions, and the package will be for your eyes only!

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Complete a Quick & Free Online Consultation

This is a quick process and should only take 1 - 2 minutes. All of your answers are confidential, and just like a GP consultation, you will know what treatment is most suitable for you instantly upon completion.

Place Your Order for Tadalafil

Once you have completed the quick online form, select the treatment option most suitable to you and checkout securely.

Express Next Day Delivery

A medical professional will review your answers to the online medical consultation and determine if it’s safe to prescribe and what treatments are available.

What is Tadalafil?

Tadalafil is a medication used to treat erectile dysfunction. It primarily treats erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) in certain circumstances. As a selective phosphodiesterase type 5 (PDE5) inhibitor, Tadalafil helps improve blood flow to the penile tissue, thus enabling a man to achieve and maintain an erection during sexual stimulation. Tadalafil has revolutionised the treatment of ED since its introduction in the early 2000s explains Dr. Graham Jackson, a leading cardiologist and sexual health expert. One of the distinctive features of Tadalafil is its long-lasting effect, as it remains active in the body for up to 36 hours, earning it the nickname "the weekend pill."

What are the benefits of Tadalafil?

Numerous benefits are associated with Tadalafil use. Firstly, it effectively treats erectile dysfunction, helping men regain their sexual confidence and improve their overall quality of life. A study published in the International Journal of Impotence Research found that men who took Tadalafil experienced a significant improvement in their erectile function source. Furthermore, Tadalafil has been shown to relieve symptoms of benign prostatic hyperplasia, including frequent urination, weak urine flow, and urgency. This dual-action effect makes it a versatile medication for men with both conditions.

How does Tadalafil work?

Tadalafil inhibits the enzyme PDE5, which breaks down cyclic guanosine monophosphate (cGMP). The presence of cGMP in the smooth muscle cells lining the blood vessels of the penis allows for relaxation and increased blood flow. During sexual stimulation, nitric oxide is released, leading to the production of cGMP. Tadalafil's inhibition of PDE5 results in higher levels of cGMP, facilitating better blood flow and enabling an erection. A detailed explanation of this mechanism is found in a review by Dr. K. Hatzimouratidis and colleagues source.

Does Tadalafil help you last longer?

Tadalafil has not been explicitly proven to help men last longer during sexual intercourse. However, it assists in maintaining an erection, which may indirectly contribute to prolonged sexual encounters. A study published in the Journal of Sexual Medicine revealed that men who took Tadalafil for erectile dysfunction experienced increased confidence and satisfaction with sexual activity.

How effective is Tadalafil as an erectile dysfunction medication?

Tadalafil is highly effective in treating erectile dysfunction, with 81% of users reporting its effectiveness (compared to a placebo) in helping to treat erectile dysfunction, according to a meta-analysis published in the International Journal of Clinical Practice. In addition, this medication has been proven effective for men with varying degrees of ED and those with underlying health conditions, such as diabetes, hypertension, and cardiovascular disease.

How long does Tadalafil last?

Tadalafil lasts for up to 36 hours, making it one of the longest-lasting erectile dysfunction medications. One of the primary advantages of Tadalafil is its long-lasting effect. The medication has a half-life of approximately 17.5 hours, which means it remains active in the body for up to 36 hours. This extended duration of action allows men to engage in sexual activity with more spontaneity and without the need for precise timing. 

Dosages of Tadalafil

Tadalafil is available in various dosages to cater to the different needs of men seeking treatment for erectile dysfunction. The most common dosages are 2.5mg, 5mg, 10mg, and 20mg. 

Tadalafil 2.5mg explained (Tadalafil Daily):

Tadalafil 2.5mg (Tadalafil Daily) is the lowest available dosage, typically prescribed as a daily dose for men who prefer the convenience of not having to time their medication intake with sexual activity. This low dose minimises the risk of side effects while maintaining its effectiveness in treating ED and BPH.

Is Tadalafil 2.5mg effective?

Although Tadalafil 2.5mg is the lowest dosage, it still effectively treats erectile dysfunction for some men. Tadalafil 2.5mg significantly improved erectile function in men with ED, according to a study published in the National Library of Medicine.

Tadalafil 5mg explained:

Tadalafil 5mg is another daily dose option, typically prescribed for men who require a slightly higher dosage to achieve optimal results.

Is Tadalafil 5mg effective?

Tadalafil 5mg has been shown to be effective in treating erectile dysfunction. A study published in the International Journal of Impotence Research demonstrated that Tadalafil 5mg daily significantly improved erectile function.

Tadalafil 10mg explained:

Tadalafil 10mg is a higher dosage, typically prescribed for men who plan to engage in sexual activity less frequently or on an as-needed basis. It is recommended to take this dose approximately 30 minutes before anticipated sexual activity.

How long does Tadalafil 10mg last?

The duration of Tadalafil 10mg is similar to the 20mg dosage, with its effects lasting up to 36 hours. This extended timeframe allows men to engage in sexual activity with more spontaneity.

Tadalafil 20mg explained:

Tadalafil 20mg is the highest available dosage for men requiring a stronger dose to achieve satisfactory results. Like the 10mg dosage, it is recommended to take this dose approximately 30 minutes before anticipated sexual activity.

How long does Tadalafil 20mg last?

The effects of Tadalafil 20mg lasts up to 36 hours, offering a prolonged window for men to engage in sexual activity without the need for precise timing. This duration of action contributes to the medication's popularity among men seeking a long-lasting and flexible treatment option for erectile dysfunction and benign prostatic hyperplasia.

What do Tadalafil pills look like?

Tadalafil pills are generally almond-shaped and come in various colours, depending on the manufacturer and dosage. The most common colours are yellow and orange. In addition, each tablet is usually marked with its dosage strength (e.g., 2.5mg, 5mg, 10mg, or 20mg) to help patients distinguish between different dosages.

Can I take Tadalafil tablets if I am taking other medication?

Before taking Tadalafil, it is essential to consult a healthcare professional to discuss the patient's medical history and any other medications the patient is taking. This is because some medicines interact with Tadalafil and lead to adverse effects. Notably, Tadalafil must not be taken with nitrates or nitric oxide donors, as this combination causes a significant drop in blood pressure.

Do Tadalafil tablets lower blood pressure?

Tadalafil causes a decrease in blood pressure due to its vasodilatory effects. In most cases, this reduction in blood pressure is not clinically significant. However, caution must be exercised if the patient is taking medications that lower blood pressure, such as alpha-blockers or nitrates, as the combined effect may cause a significant drop in blood pressure that leads to dizziness or fainting. Make sure to include any existing medications you are taking to your prescriber and on the Welzo consultation to ensure correct evaluations between current medications and tadalafil.

Is Tadalafil legal?

Tadalafil is a legal medication prescribed by a healthcare professional for erectile dysfunction or benign prostatic hyperplasia. Therefore, it is essential to obtain Tadalafil through a reputable source, such as a registered pharmacy or a doctor, to ensure that the medication is genuine and safe to use.

Does Tadalafil work after ejaculation?

Tadalafil's primary function is to improve blood flow to the penile tissue, helping men achieve and maintain an erection. After ejaculation, it is common for the erection to subside. However, due to the long-lasting effects of Tadalafil (up to 36 hours), some men are able to achieve another erection more quickly than without the medication, depending on individual refractory times and sexual stimulation.

Can women take Tadalafil tablets?

Tadalafil is not approved for use in women. It has not been extensively studied for its effects on female sexual function. Some studies have explored the potential use of Tadalafil for treating female sexual arousal disorder, but the results have been inconclusive.

Is Tadalafil available over the counter in the UK?

In the UK, Tadalafil is not available over the counter. It is a prescription-only medication, meaning a healthcare professional must assess the suitability for the treatment before prescribing it. This assessment usually involves discussing medical history, current medications, and the severity of erectile dysfunction symptoms.

What if Tadalafil is not working for me?

If Tadalafil is not producing the desired results, it is essential to consult a healthcare professional. They may recommend adjusting the dosage, trying a different PDE5 inhibitor (such as sildenafil or vardenafil), or exploring alternative treatments for erectile dysfunction, such as vacuum erection devices, penile injections, or psychotherapy. 

Is Tadalafil safe?

Tadalafil is considered safe for most men when prescribed by a healthcare professional and taken as directed. As with any medication, some side effects may occur, including headache, indigestion, back pain, muscle aches, flushing, and nasal congestion. These side effects are usually mild and temporary. However, if patients experience severe or persistent side effects, such as chest pain, an erection lasting longer than four hours, or sudden vision or hearing loss, in that case, the patient must seek immediate medical attention.

Tadalafil and alcohol

Ideally, Tadalafil must not be taken with alcohol as a rule of thumb. However, it is generally safe to consume moderate amounts of alcohol while taking Tadalafil. However, excessive alcohol consumption increases the risk of side effects, such as dizziness, headache, and low blood pressure. Additionally, alcohol may impair the ability to achieve an erection, counteracting the effects of Tadalafil. Therefore, it is advisable to limit alcohol intake while using this medication.

Is Tadalafil available on the NHS?

Tadalafil is available on the NHS to treat erectile dysfunction under specific circumstances. It is usually prescribed when other treatments, such as sildenafil, have not been effective or are not suitable due to medical reasons. The availability of Tadalafil on the NHS depends on local prescribing guidelines. 

Who can use Tadalafil?

Tadalafil is typically prescribed for adult men who are experiencing erectile dysfunction or benign prostatic hyperplasia. However, not all men are suitable candidates for Tadalafil treatment. It is not recommended for those who have had a recent heart attack or stroke, suffer from uncontrolled high or low blood pressure, or have a history of certain eye conditions, such as non-arteritic anterior ischemic optic neuropathy (NAION). A healthcare professional will assess the suitability for Tadalafil based on the medical history and any current medications being taken.

Buy Tadalafil Online

Please note the information below is intended for general knowledge, please read the patient information leaflet and/or the information provided by a healthcare professional for more specific guidance. This information should not substitute medical advice.

You can buy Tadalafil online from our UK-registered online pharmacy partners. Complete an online consultation form and our system will show you if you are eligible to purchase Tadalafil online. Our pharmacists will then review your order of Tadalafil and dispatch it discreetly to your address.

How to buy Tadalafil online?

You can buy Tadalafil by following the following steps.

  1. Fill out our online consultation form
  2. If you are eligible to purchase Tadalafil you will be shown it as one of your treatment options
  3. Pay online and receive your order to the comfort of your chosen address

Can I get Tadalafil on the NHS?

Whether or not you can get Tadalafil on the NHS is dependent on your local guidelines and eligibility status. It is best to contact your local GP service if you are unsure of whether you can get Tadalafil from the NHS.

Can you get Tadalafil over the counter?

No, you can’t get Tadalafil over the counter without a prescription or consultation. Tadalafil is a regulated medication so all purchases need to have a prescription and/or suitable consultation form completed.

Can I buy Tadalafil online even if I have never taken it before?

A prescribing pharmacist will need to review your consultation form before the medication can be dispatched. One of our partner prescribing pharmacists will review the consultation form and will decide if you are eligible to buy Tadalafil.

Is Tadalafil safe?

If you have been prescribed Tadalafil then it is at the discretion of the prescriber.

However, all medications can potentially have adverse effects and should be taken exactly as prescribed. If you experience any side effects when taking Tadalafil then you should contact a doctor immediately.

Are there any foods that should be avoided when taking Tadalafil?

We recommend you read the patient information leaflet for this product thoroughly before taking the treatment. This is essential to understanding any interactions that can occur and to take the medication safely.

Can I buy Tadalafil from Boots?

It is generally possible to purchase medication, including Tadalafil, from UK pharmacies like Boots. However, I recommend checking the Boots website or contacting Boots directly for the most current and accurate information. Remember to consult with a healthcare professional before starting any new medication.

Can I buy Tadalafil from Superdrug?

If you would like to buy Tadalafil, you will need to check availability on the Superdrug website.

Can I buy Tadalafil from Amazon?

Amazon does not sell medication such as Tadalafil, as they are not a pharmacy service provider. Always check with Amazon to see what they sell.

How long does Tadalafil take to work?

The time it takes for a Tadalafil to work can vary greatly depending on several factors, such as the strength, the individual's age, weight, and overall health, as well as any potential interactions with other medications or substances. Generally, the effects of Tadalafil may be noticeable within the time frame outlined by the prescribing pharmacist. It is important to follow the prescribed dosage and instructions provided by your healthcare professional, and to consult them if you have any concerns or questions about the medication's efficacy or possible side effects.

How effective is Tadalafil?

The effectiveness of Tadalafil can vary significantly depending on various factors, such as the dosage, the condition being treated, the individual's age, weight, and overall health, as well as the presence of any other medications or substances that might interact with it. While some medications may be highly effective for certain individuals and conditions, others might experience a lesser degree of benefit or may require adjustments to the dosage or additional treatments to achieve the desired results.

What are the risks of taking Tadalafil?

At Welzo, we are dedicated to providing our customers with accurate and comprehensive information about medications. We believe that understanding the potential risks and side effects associated with a medication is essential for making informed decisions about your health. This guide outlines some general considerations for assessing the risks of medication and includes references to the National Health Service (NHS) for further information.

  1. Read the Patient Information Leaflet (PIL): Every medication comes with a Patient Information Leaflet, which provides essential details about the drug, its uses, and potential side effects. Be sure to read this leaflet carefully before starting any new medication. The Electronic medicines compendium has a list of patient leaflets. you can visit by heading to
  2. Be aware of potential side effects: All medications have the potential to cause side effects, ranging from mild and short-lived symptoms to more serious, long-lasting issues. It's important to understand the possible side effects of a medication and how to manage them. The NHS has a helpful resource on managing medication side effects, while also speaking to a healthcare professional is important in understanding any potential risks of taking Tadalafil.
  3. Interactions with other medications: Some medications may interact with others, leading to increased side effects or reduced effectiveness. Make sure to inform your healthcare professional about all the medications and supplements you are currently taking. The NHS offers a useful tool for checking potential drug interactions here.
  4. Contraindications and precautions: Certain medical conditions or factors may make it unsafe for you to take a particular medication. Before starting any new medication, inform your healthcare professional about your medical history and any current health issues. The NHS provides more information about contraindications and precautions here.
  5. Appropriate use and dosage: It's crucial to follow the prescribed dosage and instructions for taking a medication to ensure its effectiveness and minimise the risk of side effects. The NHS has a useful guide on using medicines safely here.
  6. Monitoring and follow-up: Some medications require regular monitoring or follow-up appointments with your healthcare professional to ensure their safety and effectiveness. Be sure to schedule and attend these appointments as needed.

Can I buy Tadalafil in the UK?

Yes, you can buy Tadalafil in the UK with a valid prescription and or consultation form. Tadalafil is available in the UK for purchase from local pharmacies with a valid prescription and or consultation and to purchase from Welzo if in stock. It is imperative that you ensure that the pharmacy you are buying the products from is licensed and registered with the General Pharmaceutical Council (GPhC).

Where can I buy Tadalafil?

You can buy Tadalafil online from upon completion of a consultation form and a free review from a prescribing pharmacist.

Are Tadalafil users satisfied with the product?

We have a list of reviews from customers taking Tadalafil at the bottom of this page. For more information of the reviews of Tadalafil head over to for further details.

Can I buy Tadalafil from an online pharmacy?

Yes, you can purchase Tadalafil from an online pharmacy. However, this is dependent on your eligibility for the medication.

How much does Tadalafil cost?

The costs of Tadalafil are listed at the top of the page. Pricing is provided as a reference as treatment options will be shown upon completing the consultation form.

What is the difference between Tadalafil and Sildenafil?

Tadalafil and Sildenafil are both medications used to treat erectile dysfunction. They are similar in that they are PDE5 inhibitors and work by relaxing the muscles and increasing blood flow to the penis. However, the effects of Tadalafil may last up to 36 hours which is the longest compared to other available ED medications.

What are the dangers of Tadalafil?

Tadalafil is generally a safe medication. However, as with any medication, there are potential risks and side effects associated with its use. Some of the more common side effects include headache, indigestion, back pain, and muscle aches. These side effects are usually mild and disappear within a few hours. More serious side effects, such as sudden vision loss or an erection lasting longer than four hours, require immediate medical attention.

If you experience any side effects while taking Tadalafil, it is important to contact your doctor immediately. They will be able to determine if the medication is the cause and make any necessary changes to your treatment plan.

Is this medication suitable for me?

Please get in touch with a doctor if you are unsure what medication is suitable for you. You can also complete our online consultation form to check your eligibility for the product.

How is the medication delivered?

All orders placed before 14:00 from Monday to Friday will be dispatched that day. The orders are sent using 24 Hour Tracked delivery provided by Royal Mail. Items will usually arrive the very next day after the order has been placed. We also provide tracking for your orders to check the status and location of your parcel. All our medication is packaged in plain confidential padded white or brown envelopes. This ensures that your orders are discreet, and the content of the orders will be for your eyes only.

Can I cancel or return my order?

For non-medicinal products, you are eligible to return the product within 14 days of receipt in the same packaging you received. For medicinal products, you are eligible to cancel the order only until it has been dispatched. From that point forward, you are no longer eligible to return the order.

You have the right to cancel your order for medication up to the point when your medication is dispatched.

Can Tadalafil be used by women?

No, Tadalafil is not approved for use in women. In clinical trials, the medication was shown to be ineffective in treating sexual dysfunction in women. There is also a lack of safety data available for its use in this population. If you are a woman who is experiencing sexual difficulties, there are other treatment options available.

How long does Tadalafil take to work?

Tadalafil typically starts to work within 30 minutes to one hour after you take it. However, it can occasionally take longer for the medication to start working. If you have taken Tadalafil and it does not seem to be working, it is important to give it some time before trying a different ED medication.

How do I order my medication?

Some products only require an online consultation which approximately takes 2-3 minutes to complete, enabling you to then buy the product. Other products will also require a prescription; in this case, you will need to complete the online consultation, and then one of our partner pharmacy prescribers or doctors will review the online consultation questions and approve the order for delivery if you are eligible to purchase the item.

What is the difference between Tadalafil and Spedra?