What Is Anti-CCP Antibody?

Anti-CCP Antibody

Anti-CCP antibody is a test that predicts the presence of rheumatoid arthritis. Anti-CCP antibodies are identified in 60% to 70% of patients with rheumatoid arthritis, according to the American College of Rheumatology.

rheumatoid arthritis

These antibodies are directed against cyclic citrullinated peptides (CCP) and can be present before symptoms of rheumatoid arthritis appear.

The test aims to identify citric peptide antibodies in the body. Anti-CCP antibody is another name for CPC antibody. The antibody is a citrullinated protein that is found in the immune system. Anti-microbial medications must be effective against infections.

Autoantibodies cause illnesses by mistakenly attacking healthy cells. CMP antigens specifically target healthy joints. CCP antibodies detected on the skin may aid in the prevention of rheumatoid arthritis.

Rheumatoid arthritis is an inflammatory arthritis autoimmune disease characterised by joint inflammation and inflammatory arthritis responses.

Alternate names:

  • Cyclic citrullinated peptide antibody
  • Citrulline antibody
  • Anticitrullinated peptide antibody
  • Anti-CCP antibody
  • Anti-cyclic citrullinated peptide
  • ACPA

What Are Anti-CCP Antibodies Used For?

Anti cyclic citrullinated peptides (Anti-CCP) are autoimmune antibodies that oppose the body's natural antibodies.

Rheumatism and arthritis are frequently treated with anticipatory PC medicine. Autoantibodies assault normally healthy tissues in a specific manner.

What Is The Distinction Between Anti-CCP Antibodies And Rheumatoid Factor?

Anti-CCP antibody testing is used to aid in the diagnosis of rheumatoid arthritis. It is frequently performed concurrently with or following a rheumatoid factor (RF) test. Another sort of autoantibody is the rheumatoid factor. RF testing was once the primary means of rheumatoid arthritis diagnosis.

However, rheumatoid factors have been discovered in patients with different autoimmune disorders and in some healthy people. Many studies have demonstrated that anti-CCP antibodies, when compared to RF testing, give a more accurate diagnosis of rheumatoid arthritis.

What Information Does A CCP Test Provide?

Lab results

CCP (cyclic citrullinated peptide) antibody testing determines the presence of CCP antibodies in the blood. CCP antibodies are proteins produced in the immune system's attack against healthy tissue and cells, such as joints.

A doctor may order this test to diagnose rheumatoid arthritis (RA).

For more information and our comprehensive guide to blood tests, click here.

How Specific And Sensitive Is The Anti-CCP Test?

In rheumatism, anti-CCP may produce 75 to 79 per cent less discomfort than other drugs. Approximately two-thirds of the adverse outcomes would be an accurate negative result (no RA diagnosis), while over half of those who conducted negative anti-CCP tests were supposedly RA.

Despite being 90% specific, a CCP test does not fulfil the criteria for rheumatoid arthritis. The outcomes are that relapse can be an indication of rheumatoid arthritis.

What Medical Condition May Anti-CCP Test Help Diagnose?

As previously stated, anti-CPP has been connected to rheumatoid arthritis. Anti-CCP tests are frequently ordered in conjunction with testing for an autoantibody known as RA. Anti-CCP test is more valuable than RA-related testing in patients with early RA symptoms.

Some patients with anti-CCP antibody test positivity but no rheumatology help diagnose arthritis.

Why Do I Require A CCP Antibody Test?

Taking this medication is often used to identify rheumatoid arthritis symptoms. This test may be required if previous diagnostics have not established that rheumatology is a disease that causes arthritis.

If you have rheumatoid arthritis symptoms, you may require this test. These are some other symptoms you may experience:

  • Joint discomfort
  • Joint stiffness, especially first thing in the morning
  • Swollen joints
  • Fatigue
  • Low-grade fever

This test may also be required if the previous test fails to confirm or rule out a diagnosis of rheumatoid arthritis.

Are There Any Preparatory Measures I Should Take Before Having The Anti-CCP Test?

Always discuss all of your medications with your doctor. You should avoid certain drugs for at least 8 hours following the test.

Is There Any Risk In Taking The Test?

There are no risks or adverse effects associated with the blood sample test. You may have bruising and soreness around the insertion area, but most symptoms will disappear quickly.

What Occurs During A Test For CCP Antibodies?

A doctor can use a tiny pin to extract a blood sample from a vein in your arm. Small volumes of blood were collected in tubes and vials after the needle was placed. If the needle penetrates your skin, you may experience some discomfort. It usually takes around 10 seconds.

What Do Anti-CCP Antibody Levels Indicate?

If your CCP antibody test results were positive, it implies that these antibodies were discovered in your blood. A negative anti-CCP test result indicates that no CCP antibodies were found. The significance of these findings may be determined by the results of a rheumatoid factor (RF) test and a physical exam.

If you have rheumatoid arthritis symptoms and your findings show:

  • If you have positive CCP antibodies and positive RF, you most certainly have rheumatoid arthritis.
  • Positive anti-CCP test and negative results of RF may indicate that you have rheumatoid arthritis or will acquire it in the future.
  • If you have negative results of CCP antibodies and negative RF tests, you are less likely to get rheumatoid arthritis. Your provider may require more testing to determine what is causing your symptoms.

Is the anti-CCP Test Used To Confirm Rheumatoid Arthritis Patients?

There is also an anti-cyclic citrullinated peptide (anti-CCP) blood test available. Anti-CCP antibodies are generated by the immune system as well. Patients who get positive anti-CCP tests are more prone to develop rheumatoid arthritis. However, this antibody is not found in patients with rheumatoid arthritis.`

Is There Anything More I Should Know About Anti-CCP Antibodies?

Rheumatoid arthritis is notoriously difficult to diagnose, particularly in its early stages. In addition to the CCP antibody and RF tests, your physician may prescribe one or more additional tests.

These include joint x-rays and the following blood tests:

  • Antinuclear antibody
  • C-reactive protein
  • Synovial fluid analysis
  • Erythrocyte sedimentation rate (ESR)

These blood tests can detect inflammation.

Inflammation is an immune system reaction. It might be a sign of rheumatoid arthritis.

What Do the Results of Your Anti-CCP Test Indicate?

Less than 20 units/mL of anti-CCP antibodies constitute the normal level. Anything over this point indicates a positive antibody test, while anything below indicates a negative antibody test. Anti-CCP antibodies are detected in about 70% of RA patients.

A diagnosis does not follow naturally from a positive test result. You could have RA if you test positive for anti-CCP antibodies but not for rheumatoid factor (RF) and you have any symptoms of the condition. About 20% of RA anti-CCP negative patients on RF tests will have positive anti-CCP antibody results.

You most likely have the condition if you also test positive for RF. Your doctor will consider the findings of both antibody tests along with the CRP and ESR tests, as well as any symptoms you may be experiencing, to come to a definitive diagnosis. At the time of diagnosis, patients who test positive for anti-CCP antibodies are more likely to advance more quickly and acquire more severe types of RA.

What Medical Procedures Are Used To Treat RA?

Early RA treatment, within six months of the onset of symptoms, is essential for halting the disease's progression and minimising joint damage and disability.

If you have RA with a positive anti-CCP test, your doctor will likely follow a more aggressive course of therapy. Among these is a cocktail of pharmaceuticals known as disease-modifying antirheumatic drugs (DMARDs), which includes methotrexate (Trexall) and biologics (drugs derived from living organisms), such infliximab (Remicade) and etanercept (Enbrel).

These drugs can significantly lower anti-CCP levels in addition to symptom improvement, joint protection, and joint damage reduction. Although RA is a lifelong condition, early detection and appropriate treatment will increase your chances of limiting its progression and preserving your ability to lead an active and healthy lifestyle.

You have a significantly higher chance of acquiring RA if you test positive for anti-CCP antibodies but are otherwise healthy and don't have any signs of the illness. Even if you test negative for both anti-CCP and anti-RF antibodies, RA might still be a possibility if you have symptoms. Test results for both antibodies are negative in about 30% of RA patients.

Your doctor will need to take into account the severity of your symptoms, CRP and ESR, and imaging studies in these circumstances.

What Happens If An Anti-CCP Antibody Is Detected?

Arthritis can be considered positive RF and CCP antibodies. A positive anti-CCP antibody test and negative RF can indicate rheumatism.

What Is A High Level Of Anti-CCP?

Professional medical advice deems an anti-CCP test of more than 20 u/mL negatives. The anti-CCP tests are regarded as successful at 20 u/mL and are often diagnostic of rheumatologic arthritis.

What Is The Normal Anti-CCP Antibody Level?

Citrullinated antigens peptide anti-CCP levels are usually less than 20 units. Anti-CCP is reported within units at the hospital for surgery. Several laboratory reports with comparable results but differing measurement notation are available. A score of 20 suggests the possibility of RA.


Patients with rheumatoid arthritis frequently have anti-CCP antibodies, and these antibodies are regarded to be crucial to the development of the illness. The anti-CCP antibody test is used by doctors to identify rheumatoid arthritis and predict how the condition will progress, in addition to other tests and symptoms. A more severe type of rheumatoid arthritis is more likely to occur in those who test positive for anti-CCP antibodies. Maintaining proper vitamin D levels, treating any gum disease you may have, and giving up smoking may all help to lessen the symptoms of inflammatory joints.

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