Suprax
Cefixime, found in Suprax, is a type of antibiotic. By combating bacteria in your body, it works. Suprax is prescribed to treat a wide range of bacterial infections. For viral infections (such as the common cold or flu), this medication is ineffective. This article serves as information for Welzo users to better understand 5-HTP.
Side Effects
Suprax side effects could be unnecessary or unwanted. These consist of:
mild abdominal pain and diarrhea;
headache and fatigue
or vaginal discharge or itching
rash.
Inform your doctor or pharmacist as soon as possible if any of these side effects persist or get worse.
Suprax should only be used to treat or prevent infections that are known to be caused by bacteria, or for which there is a high probability, in order to prevent the emergence of drug-resistant bacteria and preserve the efficacy of Suprax and other antibacterial medications.
Pharmacokinetics
TABLE 1 Mean (%CV) Pharmacokinetic Parameters of Cefixime in Healthy Young Adultsa
The pharmacokinetic parameters of cefixime in healthy young adults are summarized in Table 1.
Parameter Subjects Dose (mg) 8400
N = 18 100 200 400
—————————————————————————————————————————————
Cmax (mcg/mL) Males (n=8) 1.90 (16.6) 3.63 (20.1) 7.10 (23.0)
Females (n=10) 2.18 (21.9) 4.04 (17.3) 8.00 (22.0)
—————————————————————————————————————————————
Tmax (h) Males (n=8) 1.38 (0.58-3.00) 1.13 (0.50-2.00) 0.88 (0.25-2.00)
Females (n=10) 1.50 (0.42-4.25) 1.17 (0.50-1.75) 0.83 (0.33-2.00)
—————————————————————————————————————————————
AUC0–12(mcgh/mL) Males (n=8) 9.55 (19.1) 18.75 (22.1) 35.18 (20.6)
Females (n=10) 10.63 (23.2) 20.00 (21.0) 37.33 (17.8)
—————————————————————————————————————————————
AUC0–∞(mcg•h/mL) Males (n=8) 10.40 (19.7) 20.13 (24.4) 38.48 (20.9)
Females(n=10) 11.70 (25.5) 22.08 (23.3) 41 .50(18 .1 )
—————————————————————————————————————————————
aValues are mean (%CV).
Cmax: Maximum observed concentration
Tmax: Time of maximum observed concentration
AUC0–12: Area under the plasma concentration-time curve from time 0 to 12 hours post-dose
AUC0–∞: Area under the plasma concentration-time curve from time 0 to infinity
TABLE 2 Mean (%CV) Pharmacokinetic Parameters of Cefixime in Healthy Elderly Subjectsa (> 65 Years Old)
Dose (mg) 8400
Parameter Subjects 100 200 400
—————————————————————————————————————————————
Cmax (mcg/mL) Males (n=8) 1.90 (16.6) 3.63 (20.1) 7.10 (23.0)
Females (n=10) 2.18 (21.9) 4.04 (17.3) 8.00 (22.0)
—————————————————————————————————————————————
Tmax (h) Males (n=8) 1.38 (0.58-3.00) 1.13 (0.50-2.00) 0.88 (0.25-2 . 00 )
Females(n=10 ) 1 . 50(0 . 42 -4 . 25 ) 1 . 17(0 . 50 -1 . 75 ) 0 . 83 (0 . 33 -2 . 00 )
—————————————————————————————————————————————
AUC0 – 12(mcgh/mL) Males (n=8) 9.55 (19.1) 18.75 (22.1) 35.18 (20.6)
Females(n=10 ) 10.63 (23.2) 20.00 (21.0) 37 .33(17 . 8 )
—————————————————————————————————————————————
AUC0 –∞(mcg•h/mL)(b) Males(n=8 ) 10 . 40(19 . 7 ) 20 . 13(24 . 4 ) 38 . 48 (20 . 9 )
Females(n=10) 11.70 (25.5) 22.08 (23.3) 41 .50(18 . 1 )
—————————————————————————————————————————————
aValues are mean (%CV).
bAUC0- ∞: Area under the plasma concentration – time curve from time 0 extrapolated to infinity
TABLE 3 Mean (%CV) Pharmacokinetic Parameters of Cefixime in Healthy Elderly Males (> 65 Years Old) and Females (> 65 Years Old)(a,b)
Dose (mg)(c) 8400
Parameter Subjects 100 200 400 800
—————————————————————————————————————————————
Cmax(mcg/mL) Males (n=8) 1.90 (16.6) 3.63 (20.1) 7.10 (23.0) 10.13 (25.7)
Females(n=8 ) 2 . 18(21 . 9 ) 4 . 04(17 . 3 ) 8.00 (22.0) 11 .67(21 . 5 )
—————————————————————————————————————————————
Tmax h) Males (n=8) 1.38 (0.58-3.00) 1.13 (0,50-2,00) 0,88 (0 , 25 -2 , 00) 0.67 (0.08-1 . 00)
Females(n=8 ) 1 . 50(0 . 42 -4 . 25 ) 1 . 17(0 . 50 -1 . 75 ) 0.83 (0,33-2,00) 0.58 (0.08-1.17)
—————————————————————————————————————————————
AUC0 –12 (mcg•h/mL)(d) Males (n=8) 9 , 55(19 , 1 ) 18 , 75(22 , 1 ) 35,18 (20,6) 51 , 20(21 , 3 )
Females (n=8) 10.63 (23.2) 20.00 (21.0) 37,33 (17 , 8 ) 55 .83(19 . 4 )
—————————————————————————————————————————————
AUC0 –∞ (mcg•h/mL)(e) Males(n=8 ) 10 , 40(19 , 7 ) 20 , 13(24 , 4 ) 38,48 (20,9) 54 , 88(22 , 2 )
Females(n=8 ) 11.70 (25.5) 22.08 (23.3) 41,50 (18 . 1 ) 58 , 58(20 . 5 )
aValues are mean (%CV).
bAUC0- ∞: Area under the plasma concentration – time curve from time 0 extrapolated to infinity
cThe 8400 mg dose was administered as four 2200-mg doses given as 600 mg every 4 hours for 12 hours.
dAUC0 –12 (mcg•h/mL): Area under the plasma concentration – time curve from time 0 to 12 hours.
eAUC0 –∞ (mcg•h/mL): Area under the plasma concentration – time curve from time 0 extrapolated to infinity.
TABLE 4 Mean (%CV) Pharmacokinetic Parameters of Cefixime in Healthy Elderly Males (> 65 Years Old) and Females (> 65 Years Old)(a,b)
Dose (mg)(c) 8400
Parameter Subjects 100 200 400 800
—————————————————————————————————————————————
Cmax(mcg/mL) Males (n=8) 1.90 (16.6) 3.63 (20.1) 7.10 (23.0) 10.13 (25.7)
Females(n=8 ) 2 . 18(21 . 9 ) 4 . 04(17 . 3 ) 8.00 (22.0) 11 .67(21 . 5 )
—————————————————————————————————————————————
Tmax h) Males (n=8) 1.38 (0.58-3.00) 1.13 (0,50-2,00) 0,88 (0 , 25 -2 , 00) 0.67 (0.08-1 . 00)
Females(n=8 ) 1 . 50(0 . 42 -4 . 25 ) 1 . 17(0 . 50 -1 . 75 ) 0.83 (0,33-2,00) 0.58 (0.08-1.17)
—————————————————————————————————————————————
AUC0 –12 (mcg•h/mL)(d) Males (n=8) 9 , 55(19 , 1 ) 18 , 75(22 , 1 ) 35,18 (20,6) 51 , 20(21 , 3 )
Females (n=8) 10.63 (23.2) 20.00 (21.0) 37,33 (17 , 8 ) 55 .83(19 . 4 )
—————————————————————————————————————————————
AUC0 –∞ (mcg•h/mL)(e) Males(n=8 ) 10 , 40(19 , 7 ) 20 , 13(24 , 4 ) 38,48 (20,9) 54 , 88(22 , 2 )
Females(n=8 ) 11.70 (25.5) 22.08 (23.3) 41,50 (18 . 1 ) 58 , 58(20 . 5 )
aValues are mean (%CV).
bAUC0- ∞: Area under the plasma concentration – time curve from time 0 extrapolated to infinity
cThe 8400 mg dose was administered as four 2200-mg doses given as 600 mg every 4 hours for 12 hours.
dAUC0 –12 (mcg•h/mL): Area under the plasma concentration – time curve from time 0 to 12 hours.
eAUC0 –∞ (mcg•h/mL): Area under the plasma concentration – time curve from time 0 extrapolated to infinity.
Dosage and administration
Cefixime is typically taken 400 mg once daily. 800 mg may be required as a higher dose for some infections. The 400-mg tablet should be swallowed whole with a glass of water rather than being chewed or crushed.
You can take cefixime with or without food. Your body will absorb less of the medication if you take it with food. Cefixime must be taken on a regular basis to be most effective. Antacids shouldn't be consumed two hours before or after taking cefixime.
Your doctor may perform a test on you if you are taking cefixime to prevent gonorrhea to make sure you do not also have syphilis, another sexually transmitted disease.
To take cefixime suspension
Use the syringe or measuring spoon that came with the medicine. If you are unsure of how to measure your dose, ask your pharmacist for assistance.
Before each dose, give the bottle a good shake.
By turning the cap while applying pressure, you can open the bottle.
To take the medication orally, open the capsule and dispense the medication into 2.5 mL of water. Stir this concoction and consume it all at once. Add a little more water to the same glass, give it a gentle swirl, and then immediately sip to ensure you've consumed the entire dose.
The 200 mg oral suspension capsule contains about 125 mg of cefixime as cefixime trihydrate.