When a person has type 2 diabetes, Avandamet can help them manage their blood sugar levels. Additionally, it can lessen the risk of heart attacks and strokes. Other uses for Avandamet not covered in this medication guide are also possible.
Avandamet may result in low blood sugar. Low blood sugar can cause a headache, a craving for food, sweating, confusion, irritability, dizziness, or the feeling of being shaky. Eat or drink a quick source of sugar, such as table sugar, honey, candy, orange juice, or non-diet soda, if you experience any of these symptoms. Your blood sugar level will quickly rise as a result. Then, after 15 minutes, check it once more. Take another quick bite or drink if it's still low.
Multiple doses of either rosiglitazone or metformin have no effect on their pharmacokinetics. As a result, the plasma concentrations of rosiglitazone and metformin at steady state following multiple doses are comparable to those observed following a single dose. The gastrointestinal tract quickly absorbs rosiglitazone, and peak plasma levels appear between one and four hours after oral administration. More than 90% of rosiglitazone's bioavailability has been reached. Following oral administration, metformin hydrochloride is quickly absorbed, with peak plasma concentrations occurring after about two hours. In contrast to dose, gastrointestinal tolerability (i.e., nausea) is more closely related to bioavailability. Following therapeutic doses, metformin's peak plasma concentrations are typically less than 1 g/mL.