A selective estrogen receptor modulator (SERM) is Evista (raloxifene). A SERM is a drug that functions as an anti-estrogen in some areas of the body and as an estrogen substitute in others. Osteoporosis is treated with Evista in postmenopausal women. It functions by maintaining strong bones. This article can be used by Welzo users as reference material to learn more about Evista.

Health Benefits

Evista has a lot of positive health effects. One of the most crucial benefits is that it can aid in lowering the risk of osteoporosis. In osteoporosis, bones deteriorate and become brittle. Fractures may result from this, which can be painful and incapacitating. Evista assists in maintaining bone strength, which can lower the possibility of fractures.

Evista has also been demonstrated to lower the risk of breast cancer in addition to lowering the risk of osteoporosis. Given that breast cancer is a serious illness that poses a threat to life, this is a very significant benefit. Evista can help keep women healthy and improve their quality of life by lowering the risk of breast cancer.

Side Effects

The side effects of evista are generally well tolerated, but they can occur with any medication. Leg cramps and hot flashes are the most frequent side effects. Most of the time, these side effects are minor and disappear on their own. Please call your doctor if they worsen or persist.

Among the less frequent side effects are:








Please see your doctor if you experience any of these side effects. Medical attention might be necessary for some of these side effects.


Evista is typically started at a dose of 60 mg once daily. If necessary, your doctor might raise your dose to 120 mg once daily. It is best to take Evista with food.

Take your missed Evista dose as soon as you remember. Skip the missed dose and carry on with your regular dosing schedule if it is almost time for your next dose. Never take two Evista doses at the same time.

Evista comes in 60 mg tablet form. It is also offered as a generic drug.

Mechanism of Action

Evista functions by attaching to the body's estrogen receptors. Other SERMs, like tamoxifen, bind to estrogen receptors and block their activity, but this action is different from that. The conformation (shape) of the estrogen receptor is altered by the binding of Evista to those receptors. The activity of the receptor is reduced as a result of this change.

The body's estrogenic activity is decreased as a result of Evista's binding to estrogen receptors. Breast cancer and osteoporosis risk can both be decreased as a result.


Estrogen or medications containing estrogen should not be taken together with Evista. These drugs include hormone replacement therapy, patches, rings, and birth control pills. Combining Evista with these drugs may have detrimental side effects.

There may be interactions between Evista and other drugs. Tell your doctor about all of your prescription, over-the-counter, and dietary supplements that you are taking. Tamoxifen (Soltamox) and Evista should not be taken concurrently.


Evista is efficiently absorbed from the digestive system. Its half-life is approximately 27 hours and it is metabolized in the liver. Evista is eliminated in the feces and urine.