Feldene
Piroxicam, a nonsteroidal anti-inflammatory drug prescribed to treat pain and inflammation, is sold under the brand name Feldene. Both an injectable solution and an oral capsule form of Feldene are readily available.Piroxicam is a member of the NSAID (nonsteroidal anti-inflammatory drugs) drug class. Naproxen (Aleve) and ibuprofen (Advil, Motrin) are additional medications in this class. NSAIDs function by lessening the production of prostaglandins, which are chemicals involved in inflammation and pain.Feldene received FDA approval in 1974. Pfizer is the manufacturer of it. Users of Welzo can use this article for informational purposes to better understand Accutane.
Health Benefits
Feldene is used to treat osteoarthritis and rheumatoid arthritis-related pain, swelling, and stiffness. Kids who are at least 2 years old can also use it to treat juvenile rheumatoid arthritis.
The use of feldene is not limited to those conditions detailed in this medication guide.
Side Effects
Among Feldene's frequent negative effects are:
stomach discomfort, heartburn, gas, and bloating
nausea, diarrhoea, and vomiting
constipation;
nausea, headache, and anxiety;
skin rash oritching; or
your hands or feet swelling.
Dosage
Feldene dosage for adults ranges from 20 mg to 40 mg per day. For patients with kidney disease, a daily dose of up to 20 mg is advised.
The dosage of Feldene for the treatment of juvenile rheumatoid arthritis is 0.5 mg/kg (up to 20 mg) once daily.
Mechanism of Action
Piroxicam's exact mode of action is not known. Piroxicam binds to albumin and a2-macroglobulin, according to studies done on mice and rats.
Through its impact on cyclooxygenase (COX), piroxicam also prevents prostaglandin synthesis. One of the first NSAIDs to be created specifically with the goal of inhibiting only COX-1, which causes damage to the gastric mucosa, was piroxicam. Piroxicam, however, is a non-selective COX inhibitor, which means that it inhibits both COX-1 and COX-2, according to studies.
Interactions
Feldene is an example of an NSAID that may interact with other medications you're taking. All medications, vitamins, and herbal supplements should be disclosed to your doctor, particularly:
a blood thinner like coumadin (warfarin);
steroids like methylprednisolone (Medrol) or prednisone (Rayos);
(Eskalith, Lithobid); lithium
(Rheumatrex, Trexall) methotrexate;
water pills, or diuretics;
Benazepril, captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, altace, and trandolapril are examples of ACE inhibitors. Benazepril is found in Lotensin.
Heart or blood pressure medications include nifedipine (Adalat CC, Afeditab CR, Nifedical), verapamil (Calan, Covera HS, Isoptin SR, Verelan), amlodipine (Norvasc, Lotrel, Tekamlo, Tribenzor,Twynsta), diltiazem (Cartia XT, Cardizem CD, Dilacor XR,
Pharmacokinetics
When taken orally, feldene is quickly and completely absorbed. It has a negligible amount of first-pass metabolism and 100% absolute bioavailability. Within 1-2 hours, plasma concentrations reach their peak.
A large portion of piroxicam (98%) is bound to plasma proteins, primarily albumin. Piroxicam is distributed in a volume of about 0.12 L/kg.
By means of oxidative amidation and glucuronidation/sulfation, piroxicam is broken down in the liver. A dose is excreted in the urine, feces, and as unchanged drug in the urine to a degree of 50%, 10%, and 40%, respectively. The average half-life of piroxicam's elimination is between 18 and 24 hours.
A substrate for the drug transporter P-gp is piroxicam. Therefore, piroxicam concentrations may be increased by P-gp inhibitors while decreased by P-gp inducers.
Clinical Studies
In 3 to 6 week controlled clinical trials, Feldene's effectiveness in treating the signs and symptoms of osteoarthritis and rheumatoid arthritis was assessed.
These studies reported the following unfavorable effects:
abdominal pain, diarrhea, constipation, dyspepsia, flatulence, gastric irritation, gastrointestinal bleeding or ulceration, nausea, and vomiting are all gastrointestinal symptoms.
cardiovascular: high blood pressure.
Central Nervous System: headache, nausea, drowsiness, and anxiety.
Rash is dermatological.
Edema is another.
Elevations of one or more liver enzymes happened in about 1% of patients in controlled clinical trials. These weren't connected to any other clinical features and were typically reversible after stopping Feldene.
Hepatic: a malfunctioning liver