The naturally occurring substance indole-3-carbinol (I3C) is present in cruciferous vegetables like broccoli, Brussels sprouts, cabbage, and kale. I3C is additionally offered as a supplement. I3C is occasionally marketed as a complementary cancer treatment or as a means of preventing cancer. However, these claims are not backed by any scientific data. This article is meant to provide information to Welzo users so they can better understand I3C.

Health Benefits

I3C supplements are occasionally marketed as a means of preventing or treating cancer. However, these claims are not backed by any scientific data.

I3C is occasionally promoted as a healthy substitute for traditional cancer therapies like chemotherapy. However, there is no scientific proof to back up this assertion.

I3C supplements are occasionally advertised for their alleged anti-estrogenic properties. I3C may help lower the risk of some hormone-sensitive cancers, like breast cancer, according to some research. More study is, however, required in this field.

I3C supplements are occasionally advertised as a means of enhancing detoxification and combating inflammation. However, these claims are not backed by any scientific data.

Side Effects and Safety Concerns

I3C is typically regarded as secure when taken as a supplement. However, some individuals could encounter negative effects like nausea, vomiting, and diarrhea. Before taking I3C supplements, it's important to talk to your doctor because I3C may also interact with some medications.

I3C supplements shouldn't be consumed by expectant or nursing women. To determine whether I3C is risk-free for expectant mothers and their unborn children, there is insufficient scientific evidence.

I3C supplements shouldn't be consumed by people with a history of breast cancer or other hormone-sensitive cancers. These tumors may grow faster as a result of I3C.

Children should not take I3C supplements. I3C's safety for children cannot be determined from the available scientific data.

Mechanism of Action

I3C supplements are thought to function by causing cell death (apoptosis) and preventing the growth of cancer cells. I3C might also lower the risk of some cancers like breast cancer that are hormone-sensitive.

Dosage and Preparation

There are liquid, tablet, and capsule forms of I3C supplements. I3C does not have a standard dosage, so it is crucial to adhere to the directions on the supplement label.


I3C and a number of medications, including:

Antiplatelet and anticoagulant medications: I3C may make bleeding more likely.
Therapies involving hormones: I3C may make them less effective.
St. John's wort: Combining I3C and this supplement may reduce I3C's effectiveness.
Tamoxifen: I3C may lessen this breast cancer drug's effectiveness.
Consult your doctor about any potential drug interactions prior to taking I3C supplements.


I3C is quickly taken up by the gut and processed by the liver. I3C has a half-life of around two hours.


I3C supplements cannot be used to treat or prevent cancer, according to scientific research. Ask your doctor about risk-free and efficient alternatives if you're considering using natural remedies to improve your health.

There are no known long-term effects of I3C supplementation. To determine whether I3C is risk-free for long-term use, more research is required.

Several organic compounds have been investigated for their capacity to fight cancer.

Turmeric contains the substance known as curcumin. Curcumin may promote cell death and slow the growth of cancerous cells.

Green tea: Compounds in green tea have the potential to slow the development of cancer cells.

Red wine and grapes both contain the compound known as resveratrol. The growth of cancer cells might be inhibited by resveratrol.

Silymarin: Milk thistle contains this substance. Silymarin may aid in preventing the damaging effects of chemotherapy on healthy cells.

Vitamin D: Vitamin D may aid in the prevention of some cancer types.

Zinc: Zinc may aid in halting the development of cancer cells.