Isosorbide dinitrate is quickly and completely absorbed after oral administration, reaching peak plasma concentrations in 30 to 60 minutes. Three days after receiving a once or twice daily dose, steady-state levels are reached. About 96% of isosorbide dinitrate is tightly bound to plasma proteins.
Isosorbide dinitrate has an elimination half-life of 1.5 to 3 hours. A typical 0.6 L/kg/hr of plasma is cleared each hour, with the majority of the drug's metabolites (70%) being eliminated in the urine. Isosorbide dinitrate taken orally is recovered in urine in less than 5% of its original amount.
It's possible to experience flushing (warmth, redness, or a tingly sensation), dizziness, headache, lightheadedness, or fatigue. Inform your doctor or pharmacist as soon as possible if any of these side effects persist or get worse. Get up slowly if you experience dizziness or lightheadedness after sitting up or lying down. Keep in mind that your doctor prescribed this medicine because, in his or her opinion, it will benefit you more than it will harm you. Many users of this medication report no significant side effects. If you experience any severe side effects, including fainting, contact your doctor right away. Rarely will this medication cause a very serious allergic reaction.
However, if you experience any serious allergic reaction symptoms, such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing, seek medical attention right away. The list of potential negative effects is not exhaustive.
Dosage and Administration
Oral administration of isosorbide dinitrate is possible with or without food.
Adults typically take 5 mg to 20 mg (1 to 4 tablets) four times per day. No more than 80 mg should be taken each day in total.
Adults typically take 5 mg to 10 mg (1 or 2 tablets) three to four times per day for prophylactic therapy. No more than 40 mg should be taken each day in total.
Take the missed dose of this medication as soon as you remember. If your next dose is approaching, skip the missed one and resume your regular dosing schedule. Not two doses at once.
Call the poison control hotline if you overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Dial 999 to reach the nearest emergency services if the victim has collapsed or has stopped breathing.
Overdose symptoms could include:
slow heartbeat fainting feeling faint or lightheaded tightness in the chest
Away from light and moisture, keep items at room temperature. Keep it out of the bathroom. Keep children and pets away from all medications.
Unless specifically instructed to do so, avoid flushing medications down the toilet or pouring them into drains. When the product is no longer needed or has expired, dispose of it properly. For more information on how to properly dispose of your product, speak with your pharmacist.
Regarding Isordil Titradose: Store at 77°F (25°C); excursions are allowed to 59–86°F (15–30°C).
Isordil sublingual tablets, 10 mg: Keep at 20-25 °C (68-77 °F); excursions are allowed to 15 °C (59 °F) to 30 °C (86 °F).