Antiretroviral medication called Kaletra is used to treat HIV/AIDS. It combines the effects of two medications, lopinavir and ritonavir, to stop the transmission of the AIDS-causing HIV-1 virus. In order to stop HIV-1 replication and slow the onset of AIDS, Kaletra is taken in conjunction with other antiretroviral drugs.Protease inhibitors, which include Kaletra, are a group of medications. The enzyme protease is one that HIV-1 uses to replicate. Inhibiting this enzyme is how Kaletra stops HIV-1 from replicating.Abbott Laboratories originally created Kaletra, which is now produced by AbbVie. It is legal to use in the US and numerous other nations. This article can be used by Welzo users as reference material to learn more about Kaletra.

Health Benefits

It has been demonstrated that Kaletra works well in preventing HIV-1 replication and delaying the onset of AIDS. In clinical studies, Kaletra was found to significantly lower the viral load (the amount of HIV-1 in the blood).

Additionally, kaletra has been demonstrated to boost the immune system and raise the CD4+ cell count, a crucial subset of white blood cells for warding off infection. Patients in one study who took Kaletra experienced a marked rise in their CD4+ cell count compared to those who did not take the drug.


Both tablet and liquid forms of Kaletra are accessible. Two tablets (200 mg/100 mg) twice daily, or four teaspoonfuls (40 mL) of the liquid, are the typical starting dose. Based on your weight, viral load, and other factors, your doctor will choose the appropriate dose for you.

Take Kaletra as soon as you remember if you miss a dose. Skip the missed dose and carry on with your regular dosing schedule if it is almost time for your next dose. Never combine two doses into one.

You can take Kaletra with or without food. It's crucial to take Kaletra precisely as directed by your physician.

Side Effects

Serious negative effects of kaletra include:

* Liver issues. A fatal liver failure may result from kaletra use. Those who have hepatitis B or C are more likely to experience liver issues from Kaletra. If you have liver disease now or ever had it, let your doctor know.

The pancreas. Pancreatitis, which can be fatal, can be brought on by kaletra. If you have pancreatitis or have ever had it, let your doctor know.

* Heart conditions. Heart rhythm issues brought on by kaletra have the potential to be fatal. If you have heart disease now or ever had it, let your doctor know.

* Kidney issues Kidney failure brought on by kaletra can be fatal. If you have kidney disease now or ever have, let your doctor know.

* Digestive issues. Intestinal blockage brought on by kaletra has the potential to be fatal.

Kaletra side effects that are less severe could include:

* Diarrhea

* Diarrhea

* Vomiting

* Cramps or stomachaches

* Migraine

Additionally, Kaletra may alter how your body distributes fat, which may result in issues like enlarged breasts in men, an increase in fat in the upper back and stomach, as well as a loss of fat in the face, arms, and legs.

The majority of Kaletra's side effects are minor and disappear on their own. If you experience any side effect that bothers you or does not go away, speak with your doctor.

Mechanism of Action

Lopinavir and ritonavir are the two medications that make up Kaletra. An HIV protease inhibitor is lopinavir. It functions by preventing the protease enzyme, which is necessary for the maturation and reproduction of the HIV virus. Another HIV protease inhibitor is ritonavir. It functions by increasing the body's lopinavir levels.

Generic versions of Kaletra are additionally offered. The generic Kaletra tablets were given an "AB" rating by the FDA, indicating that they are the same as the name-brand version. Kaletra's generic liquid version has not yet received a rating.


If you take any other medications, herbs, or vitamins, Kaletra may interact with them. Even if they seem unrelated to Kaletra, make sure your doctor is aware of all medications, dietary supplements, and herbal remedies you use.

Products like the following may interact with Kaletra:

* Rimactane (Rifadin, Rifampin)

* Saint John's wort

(Aptivus) Tipranavir

The list of possible drug interactions presented here is not exhaustive. Discuss all of your prescription and over-the-counter medications, as well as vitamins and herbal supplements, with your doctor and pharmacist.


Within one to two hours, Kaletra's blood concentration peaks after it is quickly absorbed. 98% of it is bonded to plasma proteins. Kaletra has a half-life of 5 to 9 hours.

Please be aware that the information on this page is provided merely for informational purposes and is not meant to be a replacement for professional medical guidance, diagnosis, or treatment. Always ask your doctor or another knowledgeable health provider for advice if you have any concerns about a medical condition. Never disregard or put off seeking professional medical advice because of something you have read on our website.