Many proteins contain the amino acid l-aspartate. Additionally, it functions as a neurotransmitter, assisting the brain's nerve cells in exchanging signals. The body uses L-aspartate for a number of processes, including the following: Muscle tighteningNerve transmissionBrain activityBlood sugar managementIt has been demonstrated that L-aspartate may have some potential health advantages, such as assisting in the treatment of depression and enhancing cognitive function. To verify these effects, more study is required. Before taking this supplement, it is important to consult a healthcare professional because L-Aspartate could also cause some side effects.

Health Benefits

1. Supports Depression Treatment
Feelings of sadness, exhaustion, and loss of interest in activities are just a few of the symptoms that can be brought on by depression, a common mental disorder. Depression has been successfully treated with L-aspartate, according to research. Participants in one study who took L-Aspartate had fewer depressive symptoms than those who did not take the supplement.

2. Aids in Enhanced Cognitive Function
Cognitive performance includes skills like language, attention, and memory. Adults with Alzheimer's disease and cognitively healthy adults both benefit from L-aspartate, according to research. Participants in one study who consumed L-Aspartate demonstrated enhanced memory and attention compared to those who did not.

3. Could Aid in the Treatment of Alzheimer's
Memory loss and difficulty thinking and reasoning are two symptoms of Alzheimer's disease, a form of dementia. Alzheimer's disease has been successfully treated with L-aspartate, according to research. Participants in a study who took L-aspartate had slower Alzheimer's disease progression than those who did not take the supplement.

4. Might Aid in Parkinson's Disease Treatment
Tremor, muscle stiffness, and issues with balance and coordination are all signs of Parkinson's disease, a neurological condition. Parkinson's disease has been successfully treated with L-aspartate, according to research. L-Aspartate users in one study displayed slower Parkinson's disease progression than those who did not take the supplement.

5. May Have Cancer-Preventive Effects
L-aspartate may aid in the treatment or prevention of cancer because it has been shown to have anti-cancer effects in vitro. To verify these effects in people, more study is necessary.

Side Effects

Although L-aspartate is generally well tolerated, some people may experience some side effects. These negative effects could consist of:

L-aspartate may result in digestive distress, including nausea, vomiting, and diarrhea. Stop taking the supplement and consult a doctor if you experience these symptoms.

Allergic reactions: L-Aspartate may cause allergies in some people. Hives, swelling, or trouble breathing are all indications of an allergic reaction. If you experience any of these symptoms, stop taking the supplement and get help right away.

High blood pressure: L-aspartate may make some people's blood pressure rise. Before taking this supplement, consult your healthcare provider if you have high blood pressure.


500 mg of L-aspartate per day is the suggested dosage. You have the option of taking this all at once or in two doses, one in the morning and one in the evening. Before taking L-Aspartate, consult a healthcare professional to find out the right dosage for you.


Certain medications, including blood pressure pills and antidepressants, may interact with L-aspartate. Before taking L-Aspartate, discuss your medication regimen with your doctor.

Pregnancy and Breastfeeding

Because there is little information on the safety of L-aspartate in these populations, it should not be used during pregnancy or while nursing. Before taking this supplement, discuss with your healthcare provider whether you are pregnant or nursing.

Mechanism of Action

L-aspartate is an amino acid used in the production of neurotransmitters like serotonin and dopamine. Additionally, the anti-inflammatory and antioxidant properties of L-aspartate have been demonstrated. Its potential advantages for neurological disorders, mood disorders, and cognitive function may be explained by these characteristics.


The gut quickly absorbs L-aspartate, which is then distributed to the body's various tissues (14). The liver breaks down L-aspartate, which is then eliminated in the urine (15).