It has been demonstrated that lactoferrin has antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as fungi and viruses. Although the exact mechanism of lactoferrin's antibacterial action is unknown, it is believed to involve binding to the surface of bacterial cells, which interferes with bacterial growth and/or function. Additionally, it has been demonstrated that lactoferrin increases macrophage bactericidal activity and stimulates phagocytosis.
Additionally, it has been demonstrated that lactoferrin has antiviral activity against a number of viruses, including the herpes simplex, HIV, HCV, and the influenza virus.
Additionally demonstrated to have immunomodulatory properties is lactoferrin. It is believed that this activity is mediated by lactoferrin's capacity to bind to immune cells like macrophages and lymphocytes and control their activity.
The antimicrobial property of lactoferrin makes it a potential treatment for infections brought on by a variety of bacteria, fungi, and viruses.
Most people tolerate lactoferrin well, and there haven't been many side effects reported. Constipation, nausea, vomiting, and diarrhea are the most typical side effects.
Boron may be important for maintaining healthy bones, according to some research. It is believed that boron aids in the body's absorption of calcium and magnesium,The pharmacokinetics of lactoferrin have been studied in a variety of different populations, including healthy adults, cancer patients, and patients with IBD.The majority of the studies have shown that lactoferrin is rapidly absorbed after oral administration, and is widely distributed throughout the body. Lactoferrin is mainly eliminated by urinary excretion, and has a short half-life of approximately 2 hours. two nutrients crucial for strong bones.
The body absorbs calcium with the aid of vitamin D, which is thought to be increased by boron.
Boron supplements may increase bone density in postmenopausal women and elderly men, according to a few small studies. These studies, however, were insufficient to conclusively demonstrate that boron has these effects.
If boron supplements can improve bone health in people who do not already have a boron deficiency, more research is required to confirm this.
Dosage and administration
The dosage of lactoferrin that is advised varies depending on the condition being treated. Two to three grams per day are suggested dosages for the treatment of infections. 10–20 grams per day are suggested as the dosage for cancer treatment. The recommended dosage for IBD treatment is 500 mg per day. And 500 mg per day is the suggested dosage for either diabetes prevention or treatment.
To increase absorption, lactoferrin should be taken with meals.