Monoamine oxidase inhibitors (MAOIs) include parnate (tranylcypromine). MAOIs are prescribed for depression. They function by halting the breakdown of a number of organic compounds in your body, including serotonin, norepinephrine, and dopamine, which lifts your mood.To treat major depressive disorder, parnate is used.The use of parnate is not limited to those indicated in this medication guide.This article can be used by Welzo users as information to help them understand Parnate.

Health Benefits

The treatment of major depressive disorder with parnate is possible. It functions by halting the breakdown of some naturally occurring chemicals in your body, including serotonin, norepinephrine, and dopamine, which lifts your mood.

Side Effects

The most typical Parnate side effects include:

unhappy stomach,







mouth is dry, or


uncommon but severe adverse effects include:




panic disorders,

a lack of sleep (insomnia),

acting upon risky impulses,

extreme joy or elation (mania),

hallucinations (seeing nonexistent objects), or

Delusions are false beliefs that are held.

Consult a doctor right away if you experience any of these uncommon but serious side effects.

There may be additional, less frequent side effects from parnate. If you experience any unusual or bothersome side effects, speak with your doctor right away.


The drug parnate is available as a tablet. With or without food, it is typically taken once or twice daily. Your doctor will start you on a low dose of Parnate and gradually increase it to reduce your risk of side effects. Carefully adhere to your doctor's instructions.

Never take Parnate in excess of what your doctor has advised. Avoid stopping Parnate abruptly because doing so may have negative side effects. Your doctor will gradually reduce your Parnate dosage if you need to stop taking it in order to prevent any withdrawal symptoms.

Mechanism of Action

Parnate functions by halting the breakdown of some naturally occurring compounds in your body, including dopamine, norepinephrine, and serotonin, which lifts your mood.


If you take herbs, vitamins, or other medications, parnate may interact with them. When a substance modifies how a drug functions, there is an interaction. This could be harmful or stop the medication from working properly.

Your doctor needs to carefully monitor all of your medications to help you avoid interactions. Tell your doctor about all of the drugs, supplements, and herbs you are taking. Speak with your doctor or pharmacist to learn how this medication may interact with other medications you are taking.

Ask your doctor or pharmacist if you have any questions about possible drug interactions that could affect you.


Following oral administration, tranylcypromine is quickly and completely absorbed from the digestive system.Tranylcypromine's bioavailability varies, but it is generally estimated to be 50%.Tranylcypromine is present in large amounts throughout the body and can cross the blood-brain barrier.The liver's CYP2C19 and other enzymes break down tranylcypromine, which is then eliminated in the urine.The half-life of tranylcypromine is roughly 3 hours.