3. Improves Cognitive Performance
4. Addresses Diabetes, ADHD, Allergies, and Asthma
1. Before taking this supplement, consult with your doctor because pycnogenol may interact with some medicines.
2. Although generally regarded as safe, pycnogenol can have some negative side effects, such as nausea and upset stomach.
3. Pycnogenol might be something to think about if you're looking for a natural way to improve your health. Nevertheless, it's crucial to consult your doctor before starting any new supplement regimen.
4. You can buy supplements containing pycnogenol both offline and online.
5. The bark of the French maritime pine tree is the source of the natural supplement pycnogenol. Procyanidins, a class of flavonoid, are abundant in it.
Pycnogenol undergoes rapid and thorough metabolism in the gut and liver after oral ingestion, resulting in low molecular weight metabolites like phenolic acids and their glucuronides, sulfates, and methylated derivatives. Within 2-4 hours after ingestion, these metabolites reach their peak plasma concentrations. Depending on the formulation taken, pycnogenol and its metabolites have different pharmacokinetic profiles. For instance, peak plasma concentrations of phenolic acids are reached two hours after ingesting pycnogenol in capsule form. Peak plasma concentrations of pycnogenol, on the other hand, are not reached until 4 hours after ingestion when it is consumed as a powder.
Pycnogenol has a variable bioavailability that is influenced by the formulation and route of administration. The bioavailability of pycnogenol, for instance, varies from 5 to 30% when taken orally as capsules.
Pycnogenol and its byproducts are primarily excreted in the urine. In plasma, pycnogenol has a half-life of about 8 hours.
Supplements containing pycnogenol can be purchased offline and online.