Relafen

Health Benefits
In order to treat the following medical conditions, relafen may be used:
Osteoarthritis
arthritis rheumatoid
Period cramps
mild to moderate discomfort
There are additional uses for relafen besides those covered in this medication guide.
Side Effects
Typical negative effects could be:
stomach discomfort, heartburn;
fatigue and a headache;
diarrhea, gas, and bloating
vomiting and/or nausea
skin rash or itching.
There may be additional side effects; this is not a comprehensive list. For medical advice about side effects, contact your doctor.
Dosage
The usual dose for adults is 500 mg twice per day.If more dosage is required, it may be increased up to a daily maximum of 2000 mg in divided doses.1000 mg once or twice daily is the typical adult starting dose for the treatment of osteoarthritis.1000 mg once daily is the typical adult starting dose for the treatment of rheumatoid arthritis.
Interactions
Any potential drug interactions may already be known to your doctor or pharmacist, who may be keeping an eye out for them.Never begin, stop, or alter the dosage of any medication without first consulting your doctor, healthcare provider, or pharmacist.
Pharmacokinetics
The gut quickly and almost entirely absorbs napumetone. In the liver, it goes through a lot of first pass metabolism to create 6-methoxy-2-naphthylacetic acid (6-MNA), which is its main active metabolite. 1-2 hours after an oral dose, nabumetone and 6-MNA both reach their peak plasma concentrations. Both substances have a strong (>99%) affinity for plasma proteins. Nabumetone has a 14–18 hour elimination half life, whereas 6-MNA has a 40–60 hour elimination half life. 10% of a dose is excreted in the feces and 60% of a dose is excreted in the urine as conjugates of nabumetone or 6-MNA.
Mechanism of Action
Nabumetone's exact mode of action is not known. However, it is believed that it works similarly to other NSAIDs by inhibiting COX-1 and COX-2 cyclooxygenases. Compared to other NSAIDs currently on the market, napumetone has a stronger affinity for COX-2.
Nabumetone has anti-inflammatory, antipyretic, and pain-relieving effects. The medicine prevents platelet aggregation as well. All of these steps work to reduce arthritis-related pain and inflammation. Nabumetone distributes easily throughout body tissues because it binds to albumin only weakly.