Requip can aid in reducing the following Parkinson's disease symptoms:
Bradykinesia, or sluggish movement
Instability of posture (balance issues)
(Involuntary movements) Dyskinesia
In addition to alleviating RLS symptoms, Requip may also be useful for treating the following:
Leg aches or burning sensations
a desire to move one's legs that is frequently accompanied by an unpleasant feeling
Leg pain causing difficulty falling or staying asleep
Leg movements that feel as though they happen when neither desired nor necessary (also known as "perceived" leg movements)
Other possible health advantages of Requip include its potential to enhance cognitive function in Parkinson's disease patients and to lessen the severity of hallucinations in schizophrenia patients.
Requip's typical side effects include:
Among the less frequent side effects are:
Insomnia, a problem sleeping
Unaccounted-for skin sensations (such as a "crawling," "itching," "pins-and-needles," or "tingling" feeling)
Having swollen hands or feet
Your ears are ringing.
Requip is typically started at a dose of 0.25 mg taken orally three times per day for Parkinson's disease. Until the desired response is obtained, the dose may be raised by 0.25–0.5 mg increments every three to seven days.
The starting dose for restless legs syndrome is 0.25 mg taken orally once daily, two to three hours prior to bedtime. Until the desired response is obtained, the dose may be raised by 0.25–0.5 mg increments every one to two weeks.
To avoid stomach upset, Requip should be taken with food or right after a meal.
Requip may have interactions with a number of drugs, including:
Levodopa or comparable Parkinson's disease medications, such as Sinemet
Anticholinergics (drugs used to treat parkinsonism, urinary issues, and stomach or intestinal problems)
Other dopamine agonists (including pergolide, cabergoline, and bromocriptine)
narcotic painkillers, including codeine
sedatives, including zolpidem
Antidepressants that are tricyclic (like amitriptyline)
MAOIs include medications like tranylcypromine, isocarboxazid, linezolid, methylene blue, phenelzine, rasagiline, and others.
medication for seizures (such as phenobarbital and carbamazepine)
medication for high blood pressure (ACE inhibitors like lisinopril, amlodipine, and beta-blockers like metoprolol)
HIV protease inhibitors, including ritonavir, atazanavir, and indinavir
Mechanism of Action
Requip functions by emulating the actions of dopamine, a neurotransmitter that carries signals between brain nerve cells.Requip can help to enhance muscle function and lessen the signs and symptoms of Parkinson's disease and restless legs syndrome by interacting with dopamine receptors.
Requip is quickly absorbed from the digestive system and goes through a significant first-pass metabolism in the liver.20% of Requip taken orally is bioavailable.Requip has a two- to three-hour half-life.