Treatment for the following conditions involves the use of trifluoperazine hydrochloride:
Trifluoperazine hydrochloride's usual side effects include:
Trifluoperazine hydrochloride side effects that are less frequent include:
nausea and diarrhoea
modifications in blood pressure
Trifluoperazine hydrochloride's severe side effects can include:
NMS, or neuroleptic malignant syndrome
Jaundice is a yellowing of the skin or eyes.
Additionally, trifluoperazine hydrochloride can lower white blood cell counts, which increases the risk of life-threatening infections.
Adults typically begin taking trifluoperazine hydrochloride at a dose of 10 to 15 mg per day. Until the desired result is obtained, the dose may be increased by 5 mg to 10 mg every three to four days. The maximum daily dose advised is 40 mg.
2.5 mg to 5 mg per day is the recommended starting dose for kids aged 6 to 12. Depending on the situation, the dose may be raised every three to four days by 2.5 mg to 5 mg. The maximum daily dose advised is 20 mg.
The recommended starting dose for kids aged 3 to 6 is 1 mg per day. If necessary, the dose can be raised by 0.5 mg every three to four days. The maximum dose advised is 5 mg.
Trifluoperazine hydrochloride may interact with vitamins, herbs, or other medications you're taking. When a substance modifies how a drug functions, there is an interaction. This could be harmful or stop the medication from working properly.
Your doctor needs to carefully monitor all of your medications to help you avoid interactions. Tell your doctor about all of the drugs, vitamins, and herbal remedies you are taking. Speak with your doctor or pharmacist to learn how this medication may interact with other medications you are taking.
Mechanism of Action
Trifluoperazine hydrochloride works by obstructing the brain's dopamine receptors. A neurotransmitter called dopamine helps control mood, appetite, and other bodily functions. Trifluoperazine hydrochloride can lessen the symptoms of schizophrenia and other mental disorders by blocking dopamine receptors.
The gastrointestinal tract absorbs trifluoperazine hydrochloride, which is extensively first-pass metabolized in the liver. Trifluoperazine hydrochloride has a bioavailability of about 50%. After oral administration, peak plasma concentrations are attained in 3 to 4 hours.
Trifluoperazine hydrochloride has a half-life of roughly 24 hours. The liver breaks down trifluoperazine hydrochloride, which is then eliminated in the urine.